American Journal of Clinical and Experimental Medicine
Volume 2, Issue 6, November 2014, Pages: 132-136
Received: Sep. 29, 2014;
Accepted: Nov. 7, 2014;
Published: Nov. 17, 2014
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Kolawole Victor Olorunshola, Department of Human Physiology, College of Health Sciences, University of Abuja, Abuja, Nigeria
Cheh Augustine Awasum, Department of Veterinary Surgery and Medicine / Veterinary Teaching Hospital, Ahmadu Bello University, Zaria, Nigeria
Nenadi Claire Hedima, Department of Veterinary Surgery and Medicine / Veterinary Teaching Hospital, Ahmadu Bello University, Zaria, Nigeria
This study was aimed at evaluating the effect of caffeine on biliary secretions in indigenous Nigerian dogs. A total of 6 dogs weighing 12 – 15 kg divided into 2 groups were used. The control group was fed their normal diet and water ad libitum and the treated group received 16 mg/kg of white crystalline caffeine dissolved in 10 mls of water and administered orally 8 hours prior to each surgery. Under sodium thiopentone and ketamine anaesthesia, common bile duct cannulation was done by the modified method of Rath and Hutchison. Bile was collected immediately post cannulation over a period of 48 to 72 hours. The bile samples from all dogs were analysed for bile volume, pH and electrolyte concentrations. The results showed significant increase in the bile volume in the caffeine treated group: 3.41 ± 0.85 ml compared to the control group: 1.24 ± 0.17 ml (p<0.05). The bile pH in the caffeine treated group: 7.40 ± 0.24 was significantly higher than the control group: 6.68 ± 0.18 (p< 0.05). The potassium concentration of 6.08 ± 0.49mmol/L in control group was significantly higher than the potassium concentration of 4.81 ± 0.21mmol/L in the treated group (p< 0.05). However, there was no significant change in the concentration of bicarbonate, chloride and sodium ions in the caffeine treated animals. We conclude that orally administered caffeine significantly increased bile volume and bile PH and significantly decreased bile potassium concentration in indigenous Nigerian dogs and these findings may have implication for digestion and absorption of fat soluble vitamins and a measure of liver functions.
Kolawole Victor Olorunshola,
Cheh Augustine Awasum,
Nenadi Claire Hedima,
Caffeine Modulates Biliary Secretions in Indigenous Nigerian Dogs, American Journal of Clinical and Experimental Medicine.
Vol. 2, No. 6,
2014, pp. 132-136.
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