American Journal of Clinical and Experimental Medicine

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The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes

Received: 26 September 2014    Accepted: 09 October 2014    Published: 20 October 2014
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Abstract

Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.

DOI 10.11648/j.ajcem.20140205.14
Published in American Journal of Clinical and Experimental Medicine (Volume 2, Issue 5, September 2014)
Page(s) 106-116
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Celiac Disease (CD), İncreased İntraepithelial Lymphocytes (İEL),Non-Spesific Duedonitis(NSD), FAS, FASL

References
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Author Information
  • Iskenderun State Hospital, Department of Pathology, Hatay, Turkey

  • Iskenderun State Hospital ,Department of Family Medicine, Hatay, Turkey

  • Bozok University Faculty of Medicine, Department of Internal Medicine, Yozgat, Turkey

  • Iskenderun State Hospital, Department of Internal Medicine, Hatay, Turkey

Cite This Article
  • APA Style

    Nurdan Tatar, Serdar Yanık, Ayse Neslin Akkoca, Zeynep Tugba Ozdemir, Mustafa Calıskan, et al. (2014). The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. American Journal of Clinical and Experimental Medicine, 2(5), 106-116. https://doi.org/10.11648/j.ajcem.20140205.14

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    Nurdan Tatar; Serdar Yanık; Ayse Neslin Akkoca; Zeynep Tugba Ozdemir; Mustafa Calıskan, et al. The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. Am. J. Clin. Exp. Med. 2014, 2(5), 106-116. doi: 10.11648/j.ajcem.20140205.14

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    AMA Style

    Nurdan Tatar, Serdar Yanık, Ayse Neslin Akkoca, Zeynep Tugba Ozdemir, Mustafa Calıskan, et al. The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes. Am J Clin Exp Med. 2014;2(5):106-116. doi: 10.11648/j.ajcem.20140205.14

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  • @article{10.11648/j.ajcem.20140205.14,
      author = {Nurdan Tatar and Serdar Yanık and Ayse Neslin Akkoca and Zeynep Tugba Ozdemir and Mustafa Calıskan and Didem Sozutek and Pınar Atasoy},
      title = {The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {2},
      number = {5},
      pages = {106-116},
      doi = {10.11648/j.ajcem.20140205.14},
      url = {https://doi.org/10.11648/j.ajcem.20140205.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20140205.14},
      abstract = {Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes
    AU  - Nurdan Tatar
    AU  - Serdar Yanık
    AU  - Ayse Neslin Akkoca
    AU  - Zeynep Tugba Ozdemir
    AU  - Mustafa Calıskan
    AU  - Didem Sozutek
    AU  - Pınar Atasoy
    Y1  - 2014/10/20
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajcem.20140205.14
    DO  - 10.11648/j.ajcem.20140205.14
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 106
    EP  - 116
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20140205.14
    AB  - Aim: Celiac disease (CD) is a chronic malabsorbtion disease of the small bowel. With a prevelance of about %1 it is a common disease in the community. FAS-FASL system which induces apopitosis is one of the most important pathways and responsible fort he development of mucosal atrophy in CD. The aim of this study is to investigate the patients who has the increase of intraepithelial lymphocytes (İEL) in duedonal mucosa and non specific duedonitis (NSD) and significance of FAS-FASL expression in these patients to distinct from CD.Materials and methods: 29 adults and 7 children celiac patients (with a preliminary diagnosis as iron deficiency anemia) and 17 adults and 6 children non-specific duedonitis patients included in the study. CD3, CD8, FAS and FASL expression were examined immunohistochemically from sections prepared from paraffin blocks in 28 adults and 7 children with normal duedonal mucosa and 24 adults and 6 children who has the increase of İEL in duedonum.Results: İn all groups; the number of İEL seen much more with CD3 in HE (hematoxylin eosin) sections . Again in all groups it is determined that majority of İEL expresses CD3 and CD8. Both in adult and children group; in surface and crypt enterosits in İEL ; the highest FAS expression was seen in enterosits and lamina propria cells in CD .More expression was determined in patients with the group who has İEL in duedonum and with NSD when compared to control group. FASL expression is increased in CD in comparison with normal but it was low in the group who has İEL in duedonum and NSD group. We found that FAS-FASL expression is not only an effective mechanism in pathogenesis of CD. We suggest that the functional significance of FAS expression should be investigated by methods of evaluating apopitosis in patients with İELAG and NSD who has more FAS expression when compared to CD . Also in the detection of number of İEL in suspected cases routine use of CD3 immunohistochemical evaluation may be useful.
    VL  - 2
    IS  - 5
    ER  - 

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