Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection
American Journal of Clinical and Experimental Medicine
Volume 2, Issue 2, March 2014, Pages: 22-27
Received: Mar. 18, 2014; Accepted: Apr. 9, 2014; Published: Apr. 20, 2014
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Oksana Sulaieva, Department of Histology, Cytology and Embryology, M. Gorky Donetsk National Medical University, Ukraine
Natalia Obraztsova, Department of Histology, Cytology and Embryology, M. Gorky Donetsk National Medical University, Ukraine
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Objective: In this review we focused on understanding the cause-and-effect relationships of gastroduodenal pathology aiming to clarify the role of vagus nerve. Results: The spectrum of vagus nerve biological effects in gastroduodenal area is related to its numerous targets and a wide range of its receptors. A variety of vagus nerve effects are related to the broad expression of cholinergic receptors on the target cells: smooth muscle cells, covering and glandular epithelium of stomach and duodenum, myofibroblasts and mast cells, vascular endothelium, intramural ganglion neurons, endocrine cells, platelets and blood leukocytes. In this paper, we discussed the following issues: 1) role of sensory nerve endings in the vagal reflex regulation; 2) impact of gastrin and leptin on vagal afferentation; 3) targets of vagus efferent nerves; 4) the role of acetylcholine in regulation of functional activity of oxyntic cells; 5) relationship of vagus efferents with enteroendocrine cells; 6) the role of vagus nerve in realization of compensatory and adaptive reactions in gastroduodenal area. Conclusion: Vagus nerve is one of the key regulators of mucosal activity and blood supply, modulating adaptive reactions and maintaining the gastrointestinal barrier
Gastroduodenal Area, Vagus Nerve, Afferent and Efferent Nerves
To cite this article
Oksana Sulaieva, Natalia Obraztsova, Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection, American Journal of Clinical and Experimental Medicine. Vol. 2, No. 2, 2014, pp. 22-27. doi: 10.11648/j.ajcem.20140202.13
Konturek SJ, Konturek PC, Brozozowski T, et al. From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century. J Physiol Pharmacology 2005; 56, 507-530.
Allen A, Flemstrom G. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 2004; 288, 1-19.
Blackshaw LA. Receptors and transmission in the brain-gut axis: potential for novel therapies.Am J Physiol Gastrointest Liver Physiol 2001; 281, 311-315.
Gyires K. Gastric mucosal protection: from prostaglandins to gene-therapy. Curr Med Chem2005; 12, №2, 203-215.
Calatayud S, Barrachina D, Esplugues JV. Nitric oxide: relation to integrity, injury, and healing of the gastric mucosa. Microsc Res Tech 2001; 53, №5, 325-335
Gyires K, Nemeth J, Zadori ZS. Gastric mucosal protection and central nervous system. Curr Pharm Des 2013; 19, №1, 34-39.
Kirkup AJ, Brunsden AM, Grundy D. Receptors and transmission in the brain-gut axis: Potential for novel therapies I. Receptors on visceral afferents. Am J Physiol Gastrointest Liver Physiol 2001; 280, 787-794.
Cui G, Waldum HL. Physiological and clinical significance of enterochromaffin-like cell activation in the regulation of gastric acid secretion. World J of Gastroenterol 2007; 13, № 4, 493-496.
Stengel A, Tache Y. Gastric peptides and their regulation of hunger and satiety. Curr. Gastroenterol Rep 2012; 14, №6, 480-488.
Ko JK, Cho CH. Adaptive cytoprotection and the brain-gut axis. Digestion 2011; 83 Suppl 1, 19-24.
Berthoud HR, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. Auton Neurosci 2000; 85, 1–17.
Powley TL, Gilbert JM, Baronowsky E.A, et al. Vagal sensory innervation of the gastric sling muscle and antral wall: implications for gastro-esophageal reflux disease? Neurogastroenterol Motil 2012; 24, №10, 526-537.
Kito Y. The functional role of intramuscular interstitial cells of Cajal in the stomach. J Smooth Muscle Res 2011; 47, №2, 47-53.
Ward SM, Sanders KM, Hirst GD. Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles. Neurogastroenterol Motil 2004; 16, 112-117.
Kang YM, Bielefeldt K, Gebhart GF. Sensitization of mechanosensitive gastric vagal afferent fibers in the rat by thermal and chemical stimuli and gastric ulcers. J Neurophysiol 2004; 91, 1981-1989.
Cummings DE, Frayo RS, Marmonier C, et al. Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 2004; 287, 297-304.
Page AJ, Slattery JA, Milte C. Ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents. Am J Physiol Gastrointest Liver Physiol 2007; 292, 1376-1384.
Yang CG, Wang WG, Yan J, et al. Gastric motility in ghrelin receptor knockout mice. Mol Med Rep 2013; 7, №1, 83-88.
Khan WI, Ghia JE. Gut hormones: emerging role in immune activation and inflammation. Clin Exp Immunol 2010; 161, №1, 19-27.
Yarandi SS, Hebbar G, Sauer CG, et al. Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation. Nutrition 2011; 27, №3, 269-275.
Lamb K, Kang YM, Gebhart GF, et al. Gastric inflammation triggers hypersensitivity to acid in awake rats. Gastroenterology 2003; 125, 1410–1418.
Martin GR, Wallace JL. Gastrointestinal inflammation: a central component of mucosal defense and repair. Exp Biol Med (Maywood) 2006; 231, №2, 130-137.
Takahashi T, Owyang C. Vagal control of nitric oxide and vasoactive intestinal polypeptide in the regulation of gastric relaxation in rat. J Physiol 2008; 484,481-492.
Musara C, Vaillant C. Immunohistochemical studies of the enteric nervous system and interstitial cells of Cajal in the canine stomach. Onderstepoort J Vet Res 2013; 80, №1, 1-4.
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