Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 1, Issue 1) |
| DOI | 10.11648/j.ajcem.20130101.11 |
| Page(s) | 1-4 |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Amlodipine, Hypertension, Sperm Count, Infertility, Body Weight
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APA Style
Huthman Ibrahim Oluwaseun, Ibrahim Bilikis, Huthman Adebukola Selimot, Otulana Jibril. (2013). Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. American Journal of Clinical and Experimental Medicine, 1(1), 1-4. https://doi.org/10.11648/j.ajcem.20130101.11
ACS Style
Huthman Ibrahim Oluwaseun; Ibrahim Bilikis; Huthman Adebukola Selimot; Otulana Jibril. Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. Am. J. Clin. Exp. Med. 2013, 1(1), 1-4. doi: 10.11648/j.ajcem.20130101.11
AMA Style
Huthman Ibrahim Oluwaseun, Ibrahim Bilikis, Huthman Adebukola Selimot, Otulana Jibril. Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. Am J Clin Exp Med. 2013;1(1):1-4. doi: 10.11648/j.ajcem.20130101.11
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Download@article{10.11648/j.ajcem.20130101.11,
author = {Huthman Ibrahim Oluwaseun and Ibrahim Bilikis and Huthman Adebukola Selimot and Otulana Jibril},
title = {Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {1},
number = {1},
pages = {1-4},
doi = {10.11648/j.ajcem.20130101.11},
url = {https://doi.org/10.11648/j.ajcem.20130101.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20130101.11},
abstract = {Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.},
year = {2013}
}
TY - JOUR T1 - Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats AU - Huthman Ibrahim Oluwaseun AU - Ibrahim Bilikis AU - Huthman Adebukola Selimot AU - Otulana Jibril Y1 - 2013/06/10 PY - 2013 N1 - https://doi.org/10.11648/j.ajcem.20130101.11 DO - 10.11648/j.ajcem.20130101.11 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 1 EP - 4 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20130101.11 AB - Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats. VL - 1 IS - 1 ER -
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