Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin

Artemii Yurievich Rynda; Dmitrii Michailovich Rostovtsev; Victor Emelijanovich Olyushin; Yliay Michaiylovna Zabrodskaya

doi:doi:10.11648/j.js.20180605.12

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Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin

Artemii Yurievich Rynda, Dmitrii Michailovich Rostovtsev, Victor Emelijanovich Olyushin, Yliay Michaiylovna Zabrodskaya

Published in Journal of Surgery (Volume 6, Issue 5)

Received: 24 July 2018 Accepted: 15 August 2018 Published: 12 September 2018

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Abstract

Objective: the purpose of this study was to assess the usefulness and accuracy of visualization of glial brain tumors of varying degrees of malignancy when surgically removed with fluorescent control of fotoditazine. Evaluation of the edges of tumor tissue was also carried out in order to increase the degree gross total resection (GTR), and to evaluate the specificity and sensitivity of the fluorescence method. Design and methods: thirty one glial tumor patients, with varying degrees of malignancy, underwent controlled fluorescence-guided resection in the presence of the indicator molecule fotoditazine. To detect fluorescence, a OHS-1 operating microscope Leica with a special fluorescence module was used. Evaluation of the efficacy, sensitivity and specificity of the method was assessed using various histo-morphological studies. GTR was assessed using postoperative MRI. Results: for grade I and II gliomas, the sensitivity of the surgical tumor removal method was 68.3%, and the specificity was 60.1%. For grade III and IV gliomas, the sensitivity of the surgical tumor removal method was 85.4%, and the specificity was 76.2%. The extent to which total surgical resection was achieved was 79.3% in grade I-II and 95.6% in grade III-IV. Conclusions: intraoperative fluorescent imaging with fotoditazine is a highly effective, sensitive, and specific method which permits glial tumors of various histologic types to be resected more completely and effectively.

Published in	Journal of Surgery (Volume 6, Issue 5)
DOI	10.11648/j.js.20180605.12
Page(s)	116-122
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fluorescence-Guided Resection, Glial Tumor, Fluorescence, Photodiagnostics, Fotoditazin

References

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APA Style

Artemii Yurievich Rynda, Dmitrii Michailovich Rostovtsev, Victor Emelijanovich Olyushin, Yliay Michaiylovna Zabrodskaya. (2018). Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin. Journal of Surgery, 6(5), 116-122. https://doi.org/10.11648/j.js.20180605.12

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ACS Style

Artemii Yurievich Rynda; Dmitrii Michailovich Rostovtsev; Victor Emelijanovich Olyushin; Yliay Michaiylovna Zabrodskaya. Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin. J. Surg. 2018, 6(5), 116-122. doi: 10.11648/j.js.20180605.12

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AMA Style

Artemii Yurievich Rynda, Dmitrii Michailovich Rostovtsev, Victor Emelijanovich Olyushin, Yliay Michaiylovna Zabrodskaya. Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin. J Surg. 2018;6(5):116-122. doi: 10.11648/j.js.20180605.12

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@article{10.11648/j.js.20180605.12,
  author = {Artemii Yurievich Rynda and Dmitrii Michailovich Rostovtsev and Victor Emelijanovich Olyushin and Yliay Michaiylovna Zabrodskaya},
  title = {Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin},
  journal = {Journal of Surgery},
  volume = {6},
  number = {5},
  pages = {116-122},
  doi = {10.11648/j.js.20180605.12},
  url = {https://doi.org/10.11648/j.js.20180605.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180605.12},
  abstract = {Objective: the purpose of this study was to assess the usefulness and accuracy of visualization of glial brain tumors of varying degrees of malignancy when surgically removed with fluorescent control of fotoditazine. Evaluation of the edges of tumor tissue was also carried out in order to increase the degree gross total resection (GTR), and to evaluate the specificity and sensitivity of the fluorescence method. Design and methods: thirty one glial tumor patients, with varying degrees of malignancy, underwent controlled fluorescence-guided resection in the presence of the indicator molecule fotoditazine. To detect fluorescence, a OHS-1 operating microscope Leica with a special fluorescence module was used. Evaluation of the efficacy, sensitivity and specificity of the method was assessed using various histo-morphological studies. GTR was assessed using postoperative MRI. Results: for grade I and II gliomas, the sensitivity of the surgical tumor removal method was 68.3%, and the specificity was 60.1%. For grade III and IV gliomas, the sensitivity of the surgical tumor removal method was 85.4%, and the specificity was 76.2%. The extent to which total surgical resection was achieved was 79.3% in grade I-II and 95.6% in grade III-IV. Conclusions: intraoperative fluorescent imaging with fotoditazine is a highly effective, sensitive, and specific method which permits glial tumors of various histologic types to be resected more completely and effectively.},
 year = {2018}
}

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TY  - JOUR
T1  - Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin
AU  - Artemii Yurievich Rynda
AU  - Dmitrii Michailovich Rostovtsev
AU  - Victor Emelijanovich Olyushin
AU  - Yliay Michaiylovna Zabrodskaya
Y1  - 2018/09/12
PY  - 2018
N1  - https://doi.org/10.11648/j.js.20180605.12
DO  - 10.11648/j.js.20180605.12
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 116
EP  - 122
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20180605.12
AB  - Objective: the purpose of this study was to assess the usefulness and accuracy of visualization of glial brain tumors of varying degrees of malignancy when surgically removed with fluorescent control of fotoditazine. Evaluation of the edges of tumor tissue was also carried out in order to increase the degree gross total resection (GTR), and to evaluate the specificity and sensitivity of the fluorescence method. Design and methods: thirty one glial tumor patients, with varying degrees of malignancy, underwent controlled fluorescence-guided resection in the presence of the indicator molecule fotoditazine. To detect fluorescence, a OHS-1 operating microscope Leica with a special fluorescence module was used. Evaluation of the efficacy, sensitivity and specificity of the method was assessed using various histo-morphological studies. GTR was assessed using postoperative MRI. Results: for grade I and II gliomas, the sensitivity of the surgical tumor removal method was 68.3%, and the specificity was 60.1%. For grade III and IV gliomas, the sensitivity of the surgical tumor removal method was 85.4%, and the specificity was 76.2%. The extent to which total surgical resection was achieved was 79.3% in grade I-II and 95.6% in grade III-IV. Conclusions: intraoperative fluorescent imaging with fotoditazine is a highly effective, sensitive, and specific method which permits glial tumors of various histologic types to be resected more completely and effectively.
VL  - 6
IS  - 5
ER  -

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Author Information

Artemii Yurievich Rynda

Department Neurooncology, Polenov Russian Research Institute of Neurosurgery, Div. Almazov National Medical Research Centre, St. Petersburg, Russia
Dmitrii Michailovich Rostovtsev

Department Neurooncology, Polenov Russian Research Institute of Neurosurgery, Div. Almazov National Medical Research Centre, St. Petersburg, Russia
Victor Emelijanovich Olyushin

Department Neurooncology, Polenov Russian Research Institute of Neurosurgery, Div. Almazov National Medical Research Centre, St. Petersburg, Russia
Yliay Michaiylovna Zabrodskaya

Department Neurooncology, Polenov Russian Research Institute of Neurosurgery, Div. Almazov National Medical Research Centre, St. Petersburg, Russia

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APA Style

Artemii Yurievich Rynda, Dmitrii Michailovich Rostovtsev, Victor Emelijanovich Olyushin, Yliay Michaiylovna Zabrodskaya. (2018). Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin. Journal of Surgery, 6(5), 116-122. https://doi.org/10.11648/j.js.20180605.12

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ACS Style

Artemii Yurievich Rynda; Dmitrii Michailovich Rostovtsev; Victor Emelijanovich Olyushin; Yliay Michaiylovna Zabrodskaya. Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin. J. Surg. 2018, 6(5), 116-122. doi: 10.11648/j.js.20180605.12

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AMA Style

Artemii Yurievich Rynda, Dmitrii Michailovich Rostovtsev, Victor Emelijanovich Olyushin, Yliay Michaiylovna Zabrodskaya. Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin. J Surg. 2018;6(5):116-122. doi: 10.11648/j.js.20180605.12

Copy | Download

@article{10.11648/j.js.20180605.12,
  author = {Artemii Yurievich Rynda and Dmitrii Michailovich Rostovtsev and Victor Emelijanovich Olyushin and Yliay Michaiylovna Zabrodskaya},
  title = {Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin},
  journal = {Journal of Surgery},
  volume = {6},
  number = {5},
  pages = {116-122},
  doi = {10.11648/j.js.20180605.12},
  url = {https://doi.org/10.11648/j.js.20180605.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180605.12},
  abstract = {Objective: the purpose of this study was to assess the usefulness and accuracy of visualization of glial brain tumors of varying degrees of malignancy when surgically removed with fluorescent control of fotoditazine. Evaluation of the edges of tumor tissue was also carried out in order to increase the degree gross total resection (GTR), and to evaluate the specificity and sensitivity of the fluorescence method. Design and methods: thirty one glial tumor patients, with varying degrees of malignancy, underwent controlled fluorescence-guided resection in the presence of the indicator molecule fotoditazine. To detect fluorescence, a OHS-1 operating microscope Leica with a special fluorescence module was used. Evaluation of the efficacy, sensitivity and specificity of the method was assessed using various histo-morphological studies. GTR was assessed using postoperative MRI. Results: for grade I and II gliomas, the sensitivity of the surgical tumor removal method was 68.3%, and the specificity was 60.1%. For grade III and IV gliomas, the sensitivity of the surgical tumor removal method was 85.4%, and the specificity was 76.2%. The extent to which total surgical resection was achieved was 79.3% in grade I-II and 95.6% in grade III-IV. Conclusions: intraoperative fluorescent imaging with fotoditazine is a highly effective, sensitive, and specific method which permits glial tumors of various histologic types to be resected more completely and effectively.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Fluorescence-Guided Resection of Glial Brain Tumors with Fotoditazin
AU  - Artemii Yurievich Rynda
AU  - Dmitrii Michailovich Rostovtsev
AU  - Victor Emelijanovich Olyushin
AU  - Yliay Michaiylovna Zabrodskaya
Y1  - 2018/09/12
PY  - 2018
N1  - https://doi.org/10.11648/j.js.20180605.12
DO  - 10.11648/j.js.20180605.12
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 116
EP  - 122
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20180605.12
AB  - Objective: the purpose of this study was to assess the usefulness and accuracy of visualization of glial brain tumors of varying degrees of malignancy when surgically removed with fluorescent control of fotoditazine. Evaluation of the edges of tumor tissue was also carried out in order to increase the degree gross total resection (GTR), and to evaluate the specificity and sensitivity of the fluorescence method. Design and methods: thirty one glial tumor patients, with varying degrees of malignancy, underwent controlled fluorescence-guided resection in the presence of the indicator molecule fotoditazine. To detect fluorescence, a OHS-1 operating microscope Leica with a special fluorescence module was used. Evaluation of the efficacy, sensitivity and specificity of the method was assessed using various histo-morphological studies. GTR was assessed using postoperative MRI. Results: for grade I and II gliomas, the sensitivity of the surgical tumor removal method was 68.3%, and the specificity was 60.1%. For grade III and IV gliomas, the sensitivity of the surgical tumor removal method was 85.4%, and the specificity was 76.2%. The extent to which total surgical resection was achieved was 79.3% in grade I-II and 95.6% in grade III-IV. Conclusions: intraoperative fluorescent imaging with fotoditazine is a highly effective, sensitive, and specific method which permits glial tumors of various histologic types to be resected more completely and effectively.
VL  - 6
IS  - 5
ER  -

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