The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients

Eman Youssef Moursy; Azza Abd El-Kareem Ismael; Reham Fadl Hassan Mouftah; Eglal Saad Ghanem El-Tahan

doi:doi:10.11648/j.ajim.s.2016040201.11

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The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients

Eman Youssef Moursy, Azza Abd El-Kareem Ismael, Reham Fadl Hassan Mouftah, Eglal Saad Ghanem El-Tahan

Published in American Journal of Internal Medicine (Volume 4, Issue 2-1)

Received: 24 August 2015 Accepted: 25 August 2015 Published: 25 October 2015

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Abstract

Objective:Insulin resistance and progressive pancreatic β-cell failure are key factors in the development of type 2 diabetes.The aim of the present study was to define the relationship between Neutrophil Lymphocyte Ratio (NLR) and the degree of insulin resistance and β cell dysfunction in Type 2Diabetus Mellitus.Methods: This study was carried out on seventy diabetic patient attended the outpatient clinic of the diabetes and metabolism unit in Alexandria Main University Hospital (AMUH)and thirty t healthy subjects with matched age, sex and socioeconomic status as a control group. Subjects were interviewed in order to collect data using predesigned questionnaire, anthropometric measures were measured, blood samples were collected from each subject for chemical analysis. Results: NLR was higher in diabetic subjects than non-diabetic one. NLR showed significant positive correlation with HOMA-IR and no significant negative correlation with HOMA-β.Conclusion: the relation between inflammation and adipose tissue is extremely complex in diabetic patients. However, simple calculation of NLR and measurement of waist circumference can reveal inflammation in the diabetic population.

Published in	American Journal of Internal Medicine (Volume 4, Issue 2-1) This article belongs to the Special Issue Different Medical Research From Middle East
DOI	10.11648/j.ajim.s.2016040201.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Insulin Resistance Syndrome, Beta Cell Dysfunction, Neutrophil Lymphocyte Ratio (NLR)

References

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APA Style

Eman Youssef Moursy, Azza Abd El-Kareem Ismael, Reham Fadl Hassan Mouftah, Eglal Saad Ghanem El-Tahan. (2015). The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients. American Journal of Internal Medicine, 4(2-1), 1-4. https://doi.org/10.11648/j.ajim.s.2016040201.11

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ACS Style

Eman Youssef Moursy; Azza Abd El-Kareem Ismael; Reham Fadl Hassan Mouftah; Eglal Saad Ghanem El-Tahan. The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients. Am. J. Intern. Med. 2015, 4(2-1), 1-4. doi: 10.11648/j.ajim.s.2016040201.11

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AMA Style

Eman Youssef Moursy, Azza Abd El-Kareem Ismael, Reham Fadl Hassan Mouftah, Eglal Saad Ghanem El-Tahan. The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients. Am J Intern Med. 2015;4(2-1):1-4. doi: 10.11648/j.ajim.s.2016040201.11

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@article{10.11648/j.ajim.s.2016040201.11,
  author = {Eman Youssef Moursy and Azza Abd El-Kareem Ismael and Reham Fadl Hassan Mouftah and Eglal Saad Ghanem El-Tahan},
  title = {The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients},
  journal = {American Journal of Internal Medicine},
  volume = {4},
  number = {2-1},
  pages = {1-4},
  doi = {10.11648/j.ajim.s.2016040201.11},
  url = {https://doi.org/10.11648/j.ajim.s.2016040201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.s.2016040201.11},
  abstract = {Objective:Insulin resistance and progressive pancreatic β-cell failure are key factors in the development of type 2 diabetes.The aim of the present study was to define the relationship between Neutrophil Lymphocyte Ratio (NLR) and the degree of insulin resistance and β cell dysfunction in Type 2Diabetus Mellitus.Methods: This study was carried out on seventy diabetic patient attended the outpatient clinic of the diabetes and metabolism unit in Alexandria Main University Hospital (AMUH)and thirty t healthy subjects with matched age, sex and socioeconomic status as a control group. Subjects were interviewed in order to collect data using predesigned questionnaire, anthropometric measures were measured, blood samples were collected from each subject for chemical analysis. Results: NLR was higher in diabetic subjects than non-diabetic one. NLR showed significant positive correlation with HOMA-IR and no significant negative correlation with HOMA-β.Conclusion: the relation between inflammation and adipose tissue is extremely complex in diabetic patients. However, simple calculation of NLR and measurement of waist circumference can reveal inflammation in the diabetic population.},
 year = {2015}
}

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TY  - JOUR
T1  - The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients
AU  - Eman Youssef Moursy
AU  - Azza Abd El-Kareem Ismael
AU  - Reham Fadl Hassan Mouftah
AU  - Eglal Saad Ghanem El-Tahan
Y1  - 2015/10/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.s.2016040201.11
DO  - 10.11648/j.ajim.s.2016040201.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.s.2016040201.11
AB  - Objective:Insulin resistance and progressive pancreatic β-cell failure are key factors in the development of type 2 diabetes.The aim of the present study was to define the relationship between Neutrophil Lymphocyte Ratio (NLR) and the degree of insulin resistance and β cell dysfunction in Type 2Diabetus Mellitus.Methods: This study was carried out on seventy diabetic patient attended the outpatient clinic of the diabetes and metabolism unit in Alexandria Main University Hospital (AMUH)and thirty t healthy subjects with matched age, sex and socioeconomic status as a control group. Subjects were interviewed in order to collect data using predesigned questionnaire, anthropometric measures were measured, blood samples were collected from each subject for chemical analysis. Results: NLR was higher in diabetic subjects than non-diabetic one. NLR showed significant positive correlation with HOMA-IR and no significant negative correlation with HOMA-β.Conclusion: the relation between inflammation and adipose tissue is extremely complex in diabetic patients. However, simple calculation of NLR and measurement of waist circumference can reveal inflammation in the diabetic population.
VL  - 4
IS  - 2-1
ER  -

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Author Information

Eman Youssef Moursy

Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Azza Abd El-Kareem Ismael

Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Reham Fadl Hassan Mouftah

Department of Clinical Pathology, Faculty of Medicine, Alexandria University,Alexandria, Egypt
Eglal Saad Ghanem El-Tahan

Alexandria Fever Hospital, Ministry of Health, Alexandria, Egypt

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APA Style

Eman Youssef Moursy, Azza Abd El-Kareem Ismael, Reham Fadl Hassan Mouftah, Eglal Saad Ghanem El-Tahan. (2015). The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients. American Journal of Internal Medicine, 4(2-1), 1-4. https://doi.org/10.11648/j.ajim.s.2016040201.11

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ACS Style

Eman Youssef Moursy; Azza Abd El-Kareem Ismael; Reham Fadl Hassan Mouftah; Eglal Saad Ghanem El-Tahan. The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients. Am. J. Intern. Med. 2015, 4(2-1), 1-4. doi: 10.11648/j.ajim.s.2016040201.11

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AMA Style

Eman Youssef Moursy, Azza Abd El-Kareem Ismael, Reham Fadl Hassan Mouftah, Eglal Saad Ghanem El-Tahan. The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients. Am J Intern Med. 2015;4(2-1):1-4. doi: 10.11648/j.ajim.s.2016040201.11

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@article{10.11648/j.ajim.s.2016040201.11,
  author = {Eman Youssef Moursy and Azza Abd El-Kareem Ismael and Reham Fadl Hassan Mouftah and Eglal Saad Ghanem El-Tahan},
  title = {The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients},
  journal = {American Journal of Internal Medicine},
  volume = {4},
  number = {2-1},
  pages = {1-4},
  doi = {10.11648/j.ajim.s.2016040201.11},
  url = {https://doi.org/10.11648/j.ajim.s.2016040201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.s.2016040201.11},
  abstract = {Objective:Insulin resistance and progressive pancreatic β-cell failure are key factors in the development of type 2 diabetes.The aim of the present study was to define the relationship between Neutrophil Lymphocyte Ratio (NLR) and the degree of insulin resistance and β cell dysfunction in Type 2Diabetus Mellitus.Methods: This study was carried out on seventy diabetic patient attended the outpatient clinic of the diabetes and metabolism unit in Alexandria Main University Hospital (AMUH)and thirty t healthy subjects with matched age, sex and socioeconomic status as a control group. Subjects were interviewed in order to collect data using predesigned questionnaire, anthropometric measures were measured, blood samples were collected from each subject for chemical analysis. Results: NLR was higher in diabetic subjects than non-diabetic one. NLR showed significant positive correlation with HOMA-IR and no significant negative correlation with HOMA-β.Conclusion: the relation between inflammation and adipose tissue is extremely complex in diabetic patients. However, simple calculation of NLR and measurement of waist circumference can reveal inflammation in the diabetic population.},
 year = {2015}
}

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TY  - JOUR
T1  - The Value of Neutrophil Lymphocyte Ratio in Predicting the Degree of Insulin Resistance and β Cell Dysfunction in Type 2 Diabetic Patients
AU  - Eman Youssef Moursy
AU  - Azza Abd El-Kareem Ismael
AU  - Reham Fadl Hassan Mouftah
AU  - Eglal Saad Ghanem El-Tahan
Y1  - 2015/10/25
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.s.2016040201.11
DO  - 10.11648/j.ajim.s.2016040201.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.s.2016040201.11
AB  - Objective:Insulin resistance and progressive pancreatic β-cell failure are key factors in the development of type 2 diabetes.The aim of the present study was to define the relationship between Neutrophil Lymphocyte Ratio (NLR) and the degree of insulin resistance and β cell dysfunction in Type 2Diabetus Mellitus.Methods: This study was carried out on seventy diabetic patient attended the outpatient clinic of the diabetes and metabolism unit in Alexandria Main University Hospital (AMUH)and thirty t healthy subjects with matched age, sex and socioeconomic status as a control group. Subjects were interviewed in order to collect data using predesigned questionnaire, anthropometric measures were measured, blood samples were collected from each subject for chemical analysis. Results: NLR was higher in diabetic subjects than non-diabetic one. NLR showed significant positive correlation with HOMA-IR and no significant negative correlation with HOMA-β.Conclusion: the relation between inflammation and adipose tissue is extremely complex in diabetic patients. However, simple calculation of NLR and measurement of waist circumference can reveal inflammation in the diabetic population.
VL  - 4
IS  - 2-1
ER  -

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