American Journal of Internal Medicine

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Outcome of Paraquat Self-poisoning a Case series

Received: 29 March 2015    Accepted: 09 April 2015    Published: 23 October 2015
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Abstract

Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.

DOI 10.11648/j.ajim.s.2015030601.11
Published in American Journal of Internal Medicine (Volume 3, Issue 6-1, November 2015)

This article belongs to the Special Issue Toxicology

Page(s) 1-4
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Paraquat, Charcol hemoperfusion, Immunosuppressive therapy, ARDS, Renal and hepatic dysfunction

References
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Author Information
  • Department of Medicine, Government Medical College, Thrissur, Kerala, India

  • Department of Medicine, Government Medical College, Thrissur, Kerala, India

  • Department of Forensic medicine, Government Medical College, Thrissur, Kerala, India

  • Department of Community medicine, Government Medical College, Thrissur, Kerala, India

  • Department of Medicine, Government Medical College, Thrissur, Kerala, India

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  • APA Style

    M Indira, Rakesh T P, Hithesh Shankar T S, Suchithra E T, Andrews M A. (2015). Outcome of Paraquat Self-poisoning a Case series. American Journal of Internal Medicine, 3(6-1), 1-4. https://doi.org/10.11648/j.ajim.s.2015030601.11

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    ACS Style

    M Indira; Rakesh T P; Hithesh Shankar T S; Suchithra E T; Andrews M A. Outcome of Paraquat Self-poisoning a Case series. Am. J. Intern. Med. 2015, 3(6-1), 1-4. doi: 10.11648/j.ajim.s.2015030601.11

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    AMA Style

    M Indira, Rakesh T P, Hithesh Shankar T S, Suchithra E T, Andrews M A. Outcome of Paraquat Self-poisoning a Case series. Am J Intern Med. 2015;3(6-1):1-4. doi: 10.11648/j.ajim.s.2015030601.11

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  • @article{10.11648/j.ajim.s.2015030601.11,
      author = {M Indira and Rakesh T P and Hithesh Shankar T S and Suchithra E T and Andrews M A},
      title = {Outcome of Paraquat Self-poisoning a Case series},
      journal = {American Journal of Internal Medicine},
      volume = {3},
      number = {6-1},
      pages = {1-4},
      doi = {10.11648/j.ajim.s.2015030601.11},
      url = {https://doi.org/10.11648/j.ajim.s.2015030601.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajim.s.2015030601.11},
      abstract = {Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.},
     year = {2015}
    }
    

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    T1  - Outcome of Paraquat Self-poisoning a Case series
    AU  - M Indira
    AU  - Rakesh T P
    AU  - Hithesh Shankar T S
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    AU  - Andrews M A
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    DO  - 10.11648/j.ajim.s.2015030601.11
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
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    AB  - Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.
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