American Journal of Internal Medicine

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Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites

Received: 01 January 2017    Accepted: 20 January 2017    Published: 20 February 2017
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Abstract

Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.

DOI 10.11648/j.ajim.20170501.13
Published in American Journal of Internal Medicine (Volume 5, Issue 1, January 2017)
Page(s) 12-17
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Midodirine, Refractory Ascites, Liver Cirrhosis

References
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[2] Planas R, Montoliu S, Balleste B et al., (2006): Natural history of patients hospitalized for management of cirrhotic ascites. Clin. Gastroenterol. Hepatol. 4: 1385–94.
[3] Salerno F, Cammà C, Enea M, Rِssle M, Wong F. (2007): Transjugular intrahepatic portosystemic shunt for refractory ascites: a meta-analysis of individual patient data. Gastroenterology. 133: 825–34.
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Author Information
  • Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt

  • Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt

  • Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt

  • Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt

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  • APA Style

    Ahmed A. Obiedallah, Essam Abdelmohsen, Abdalla I. Kelani, Mohamed Mousa. (2017). Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. American Journal of Internal Medicine, 5(1), 12-17. https://doi.org/10.11648/j.ajim.20170501.13

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    ACS Style

    Ahmed A. Obiedallah; Essam Abdelmohsen; Abdalla I. Kelani; Mohamed Mousa. Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. Am. J. Intern. Med. 2017, 5(1), 12-17. doi: 10.11648/j.ajim.20170501.13

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    AMA Style

    Ahmed A. Obiedallah, Essam Abdelmohsen, Abdalla I. Kelani, Mohamed Mousa. Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. Am J Intern Med. 2017;5(1):12-17. doi: 10.11648/j.ajim.20170501.13

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  • @article{10.11648/j.ajim.20170501.13,
      author = {Ahmed A. Obiedallah and Essam Abdelmohsen and Abdalla I. Kelani and Mohamed Mousa},
      title = {Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites},
      journal = {American Journal of Internal Medicine},
      volume = {5},
      number = {1},
      pages = {12-17},
      doi = {10.11648/j.ajim.20170501.13},
      url = {https://doi.org/10.11648/j.ajim.20170501.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajim.20170501.13},
      abstract = {Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites
    AU  - Ahmed A. Obiedallah
    AU  - Essam Abdelmohsen
    AU  - Abdalla I. Kelani
    AU  - Mohamed Mousa
    Y1  - 2017/02/20
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ajim.20170501.13
    DO  - 10.11648/j.ajim.20170501.13
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 12
    EP  - 17
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20170501.13
    AB  - Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.
    VL  - 5
    IS  - 1
    ER  - 

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