American Journal of Internal Medicine

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Pyelonephritis in Adult Women with Homozygous Sickle Cell Disease: about 42 Cases

Received: 03 February 2014    Accepted:     Published: 10 March 2014
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Abstract

Sickle cell disease is a condition with 3 parts of speech including infectious complications. They are essentially encapsulated bacterial organisms. There is a significant incidence of urinary infections to adults with sickle cell disease most particularly among women. The frequency and characteristics of pyelonephritis in women with sickle cell disease is poorly understood to this day, it seemed interesting to analyze over a period of one year, the profile of sickle cell patients followed in the genetic disease unit of red blood cell Hospital Henri Mondor, Créteil, and who took at least one episode of pyelonephritis. Patients and Methods: This study was conducted in the genetic disease unit of red blood cell (UMGGR) Hospital Henri Mondor in Créteil (France). This is a retrospective descriptive and analytical study on patients with homozygous sickle cell disease, females, aged 18 years or more. The selection was conducted over a period of one year from February 2007 to February 2008. Data were collected from medical records and from reports of record of each patient. We considered the clinical, paraclinical and therapeutic latest episode of pyelonephritis. Data processing was done using the software Statview. Results: The prevalence of pyelonephritis in women with sickle cell disease aged over 15 years was 6.12% annually. The median age at first episode of pyelonephritis was 23.5 years. The majority (71.42%) was the first episode after 20 years. Among the factors predisposing to pyelonephritis, pregnancy has been implicated in 16.7% of cases. The symptoms of cystitis, with 52.4%, were the fact favoring predominant. The average number episodes of pyelonephritis to our patients were 2. The risk of recurrent pyelonephritis was significantly correlated statistically with the presence of cholelithiasis (p = 0.04). Fever was the clinical symptoms that prompted the consultation in 95.24% cases. The consequences of sickle cell disease were important. We identified 16.7% cases of sepsis and 16.7% of worsening anemia requiring transfusion. The causative agent was E. coli in 85.7% of patients. 61.9% of patients received combination therapy. The intravenous therapy as first-line was found in 81%. Fluoroquinolones were the molecules widely used in 71.4% of cases. The rate of clinical failure at 3 days of antibiotics was 4.76%. The average time for obtaining apyrexia was 3 days. The average duration of treatment was 15 days. We observed no cases of death secondary to the episode of pyelonephritis. Conclusion: This preliminary work has highlighted the incidence of pyelonephritis in women adult with sickle cell and the the potential impact on sickle cell disease. Despite being underestimated because of the retrospective nature and short duration (1 year) of study, this frequency must motivate strategy to encourage more active educational preventive towards patients and early diagnosis of urinary tract infections to women with sickle cell disease.

DOI 10.11648/j.ajim.20140202.11
Published in American Journal of Internal Medicine (Volume 2, Issue 2, March 2014)
Page(s) 10-14
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pyelonephritis, Adult Women, Homozygous Sickle Cell Disease

References
[1] Zarouk V., P. Lesprit. Infection in adult with sickle cell disease. In The Sickle Cell Disease, 2003 : 117-123
[2] Zarrouk V., Habibi A., Zahar Jr., Roubot-Thoraval F., Bachir D., et al. Bloodstream infection in adults with Sickle Cell Disease. Association with venous cathethers, staphylococcus aureus, and bone-joint infections. Med. 2006, 85; 1: 43-47.
[3] Fort A, Morrisson J, Borreras L, Diggs L, Fish S. conseling the patient with sickle cell disease about reproduction : pregnancy outcome does not justify the maternal risk. Am J Obstet Gynecol 1971; 111: 324-7.
[4] Rust Oa. Pregnancy complicated by sickle hemoglobinopathy. Clin Obstet Gunecol 1995; 38: 462-84.
[5] Sun Pm, Wilburn W, Raynor Bd, Jamieson D. sickle cell disease in pregnancy: twenty years of experience at grady Memorial Hospital, Atlanta, Geaorgia. Am J Obstet Gynecol. 2001; 184: 1127-30.
[6] Vidal Recos. Acute pyelonephritis in adults. www.vidalrecos.fr/pages/reco.php?defche=153187
[7] Leborgne-Samuel Y, Kadhel P, Ryan C, Vendittelli F. Sickle cell disease and pregnancy. Rev Prat 2004, 30 ; 54 : 1578-82
[8] Bruni D, Wigfall Dr, Zimmerman Sa, Rasoff Pm, Wiener Js. Genitourinary complications of sickle cell disease. J Urol 2001, 166; 3 803-11
[9] De Pont Ac, Wolf H, Van Delden Om, De Reijke Tm. Pyelonephritis during pregnancy: a threat to mother and child. Ned TTijdschr Geneeskd 2008, 5; 152: 58.
[10] Meyrier Alain Pyélonéphrites aiguës: infections of the urinary tract. Rev Prat 2003, 53 ; 16 : 1777-84.
[11] Acute pyelonephritis. Randomised double-blind comparison of ciprofloxacin and tobramycin. www.spc.univ-lyon.fr/lecture-critique/TP/travail_sur_article/infection_urinaire/article.htlm-20k
[12] Howard Rj. Management of sickling conditions in pregnancy. Br J Hosp Med 1996; 56: 7 – 10.
[13] Podard D, Maude G, Plant M, Scorer H, Serjeant G. Pregnancy in Jamaican women with homozygous sickle cell disease. Fetal and maternal outcome. Br J Obstet Gynecol 1986; 93: 927-32.
[14] Stefanescu D. Sickle cell disease and pregnancy. Doctorat Thesis. Université René-Descartes (Paris VI) 2001 : 11.
[15] Anonymous. Hemoglobinopathies in pregnancy. Int J Gynecol Obstet 1993 ; 43 : 333-42.
[16] Ataga Ki, Orringer Ep. Renal abnormalities in sickle cell disease. Am J Hematol. 2000; 63: 205-11.
[17] Remy P. Renal complications of sickle cell disease. In La Drépanocytose, 2003 : 117-123
Author Information
  • National Blood Transfusion Center (NBTC), Abidjan, C?te d’Ivoire;Clinical Hematology, Yopougon Teaching Hospital, Abidjan, C?te d’Ivoire;Genetic disease unit of red blood cell (UMGGR), Hospital Henri Mondor, Créteil, France

  • National Blood Transfusion Center (NBTC), Abidjan, C?te d’Ivoire

  • Clinical Hematology, Yopougon Teaching Hospital, Abidjan, C?te d’Ivoire

  • National Blood Transfusion Center (NBTC), Abidjan, C?te d’Ivoire

  • National Blood Transfusion Center (NBTC), Abidjan, C?te d’Ivoire

  • Clinical Hematology, Yopougon Teaching Hospital, Abidjan, C?te d’Ivoire

  • Genetic disease unit of red blood cell (UMGGR), Hospital Henri Mondor, Créteil, France

  • National Blood Transfusion Center (NBTC), Abidjan, C?te d’Ivoire

  • National Blood Transfusion Center (NBTC), Abidjan, C?te d’Ivoire

  • National Blood Transfusion Center (NBTC), Abidjan, C?te d’Ivoire

  • National Blood Transfusion Center (NBTC), Abidjan, C?te d’Ivoire

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    Sekongo Yassongui Mamadou, Abisse Agba, Tolo-Diebkile Aissata, Konan Sidoine, Kouamenan Sidonie, et al. (2014). Pyelonephritis in Adult Women with Homozygous Sickle Cell Disease: about 42 Cases. American Journal of Internal Medicine, 2(2), 10-14. https://doi.org/10.11648/j.ajim.20140202.11

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    ACS Style

    Sekongo Yassongui Mamadou; Abisse Agba; Tolo-Diebkile Aissata; Konan Sidoine; Kouamenan Sidonie, et al. Pyelonephritis in Adult Women with Homozygous Sickle Cell Disease: about 42 Cases. Am. J. Intern. Med. 2014, 2(2), 10-14. doi: 10.11648/j.ajim.20140202.11

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    AMA Style

    Sekongo Yassongui Mamadou, Abisse Agba, Tolo-Diebkile Aissata, Konan Sidoine, Kouamenan Sidonie, et al. Pyelonephritis in Adult Women with Homozygous Sickle Cell Disease: about 42 Cases. Am J Intern Med. 2014;2(2):10-14. doi: 10.11648/j.ajim.20140202.11

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  • @article{10.11648/j.ajim.20140202.11,
      author = {Sekongo Yassongui Mamadou and Abisse Agba and Tolo-Diebkile Aissata and Konan Sidoine and Kouamenan Sidonie and Danho Nanho Clotaire and Dora B. and Kassougue Kadidia and N’Guessan Koutoua Parfait and Konate Seidou and Galacteros F.},
      title = {Pyelonephritis in Adult Women with Homozygous Sickle Cell Disease: about 42 Cases},
      journal = {American Journal of Internal Medicine},
      volume = {2},
      number = {2},
      pages = {10-14},
      doi = {10.11648/j.ajim.20140202.11},
      url = {https://doi.org/10.11648/j.ajim.20140202.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajim.20140202.11},
      abstract = {Sickle cell disease is a condition with 3 parts of speech including infectious complications. They are essentially encapsulated bacterial organisms. There is a significant incidence of urinary infections to adults with sickle cell disease most particularly among women. The frequency and characteristics of pyelonephritis in women with sickle cell disease is poorly understood to this day, it seemed interesting to analyze over a period of one year, the profile of sickle cell patients followed in the genetic disease unit of red blood cell Hospital Henri Mondor, Créteil, and who took at least one episode of pyelonephritis. Patients and Methods: This study was conducted in the genetic disease unit of red blood cell (UMGGR) Hospital Henri Mondor in Créteil (France). This is a retrospective descriptive and analytical study on patients with homozygous sickle cell disease, females, aged 18 years or more. The selection was conducted over a period of one year from February 2007 to February 2008. Data were collected from medical records and from reports of record of each patient. We considered the clinical, paraclinical and therapeutic latest episode of pyelonephritis. Data processing was done using the software Statview. Results: The prevalence of pyelonephritis in women with sickle cell disease aged over 15 years was 6.12% annually. The median age at first episode of pyelonephritis was 23.5 years. The majority (71.42%) was the first episode after 20 years. Among the factors predisposing to pyelonephritis, pregnancy has been implicated in 16.7% of cases. The symptoms of cystitis, with 52.4%, were the fact favoring predominant. The average number episodes of pyelonephritis to our patients were 2. The risk of recurrent pyelonephritis was significantly correlated statistically with the presence of cholelithiasis (p = 0.04). Fever was the clinical symptoms that prompted the consultation in 95.24% cases. The consequences of sickle cell disease were important. We identified 16.7% cases of sepsis and 16.7% of worsening anemia requiring transfusion. The causative agent was E. coli in 85.7% of patients. 61.9% of patients received combination therapy. The intravenous therapy as first-line was found in 81%. Fluoroquinolones were the molecules widely used in 71.4% of cases. The rate of clinical failure at 3 days of antibiotics was 4.76%. The average time for obtaining apyrexia was 3 days. The average duration of treatment was 15 days. We observed no cases of death secondary to the episode of pyelonephritis. Conclusion: This preliminary work has highlighted the incidence of pyelonephritis in women adult with sickle cell and the the potential impact on sickle cell disease. Despite being underestimated because of the retrospective nature and short duration (1 year) of study, this frequency must motivate strategy to encourage more active educational preventive towards patients and early diagnosis of urinary tract infections to women with sickle cell disease.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Pyelonephritis in Adult Women with Homozygous Sickle Cell Disease: about 42 Cases
    AU  - Sekongo Yassongui Mamadou
    AU  - Abisse Agba
    AU  - Tolo-Diebkile Aissata
    AU  - Konan Sidoine
    AU  - Kouamenan Sidonie
    AU  - Danho Nanho Clotaire
    AU  - Dora B.
    AU  - Kassougue Kadidia
    AU  - N’Guessan Koutoua Parfait
    AU  - Konate Seidou
    AU  - Galacteros F.
    Y1  - 2014/03/10
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajim.20140202.11
    DO  - 10.11648/j.ajim.20140202.11
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 10
    EP  - 14
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20140202.11
    AB  - Sickle cell disease is a condition with 3 parts of speech including infectious complications. They are essentially encapsulated bacterial organisms. There is a significant incidence of urinary infections to adults with sickle cell disease most particularly among women. The frequency and characteristics of pyelonephritis in women with sickle cell disease is poorly understood to this day, it seemed interesting to analyze over a period of one year, the profile of sickle cell patients followed in the genetic disease unit of red blood cell Hospital Henri Mondor, Créteil, and who took at least one episode of pyelonephritis. Patients and Methods: This study was conducted in the genetic disease unit of red blood cell (UMGGR) Hospital Henri Mondor in Créteil (France). This is a retrospective descriptive and analytical study on patients with homozygous sickle cell disease, females, aged 18 years or more. The selection was conducted over a period of one year from February 2007 to February 2008. Data were collected from medical records and from reports of record of each patient. We considered the clinical, paraclinical and therapeutic latest episode of pyelonephritis. Data processing was done using the software Statview. Results: The prevalence of pyelonephritis in women with sickle cell disease aged over 15 years was 6.12% annually. The median age at first episode of pyelonephritis was 23.5 years. The majority (71.42%) was the first episode after 20 years. Among the factors predisposing to pyelonephritis, pregnancy has been implicated in 16.7% of cases. The symptoms of cystitis, with 52.4%, were the fact favoring predominant. The average number episodes of pyelonephritis to our patients were 2. The risk of recurrent pyelonephritis was significantly correlated statistically with the presence of cholelithiasis (p = 0.04). Fever was the clinical symptoms that prompted the consultation in 95.24% cases. The consequences of sickle cell disease were important. We identified 16.7% cases of sepsis and 16.7% of worsening anemia requiring transfusion. The causative agent was E. coli in 85.7% of patients. 61.9% of patients received combination therapy. The intravenous therapy as first-line was found in 81%. Fluoroquinolones were the molecules widely used in 71.4% of cases. The rate of clinical failure at 3 days of antibiotics was 4.76%. The average time for obtaining apyrexia was 3 days. The average duration of treatment was 15 days. We observed no cases of death secondary to the episode of pyelonephritis. Conclusion: This preliminary work has highlighted the incidence of pyelonephritis in women adult with sickle cell and the the potential impact on sickle cell disease. Despite being underestimated because of the retrospective nature and short duration (1 year) of study, this frequency must motivate strategy to encourage more active educational preventive towards patients and early diagnosis of urinary tract infections to women with sickle cell disease.
    VL  - 2
    IS  - 2
    ER  - 

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