Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window

Wan Yingjun; Ma Fengmei; Zhao Changzhen

doi:doi:10.11648/j.sjph.20200802.15

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Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window

Wan Yingjun, Ma Fengmei, Zhao Changzhen

Published in Science Journal of Public Health (Volume 8, Issue 2)

Received: 14 April 2020 Accepted: Published: 29 May 2020

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Abstract

Objective To study expression of integrin and epidermal growth factor in sterile patients during endometrial implantation window and discuss the relationship between the integrin and epidermal growth factor and endometrial receptivity. Methods: The research objects were divided into 5 groups with 30 women at the normal gestation age, 30 women exhibiting ovulation following PCOS ovulation induction treatment, 26 women exhibiting no ovulation following PCOS ovulation induction treatment, 38 women exhibiting oviduct obstruction, 32 women exhibiting hydrosalpinx. An immunohistochemical method was used to detect the expression of integrin and EGF in sterile women of the five groups of research objects during endometrial implantation window and a statistical analysis was conducted for all detection results. Results The expression level of the integrin in PCOS group is significantly lower than that in the control group and the difference is significant (P<0.05); the expression level of the integrin in PCOS anovulation group is significantly lower than that in PCOS ovulation group and there is statistical significance (P<0.05); the difference between the oviduct obstruction group and the control group is not significant (P>0.05); the expression level of the integrin in the hydrosalpinx group is lower than that in the oviduct obstruction group and the difference is significant (P<0.05). EGF is expressed in endometria of various groups of women and its expression is located in cytoplasm of epithelial cells of the endometrial gland. Conclusion Integrin and epidermal growth factor are expressed in endometria of various groups of women in the implantation phase indicating that they may be important regulatory factors for endometrial receptivity and embryonic implantation.

Published in	Science Journal of Public Health (Volume 8, Issue 2)
DOI	10.11648/j.sjph.20200802.15
Page(s)	56-62
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Integrin, Epidermal Growth Factor, Sterile Women, Endometrium, Implantation Window Phase

References

[1]	Lessey BA. Lebovic DI. et al. Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects [J]. Semin Reprod Med, 2013, 31 (2): 109-24.
[2]	Sak ME. Gul T. et al. Fibroblast growth factor-1 expression in the endometrium of patients with repeated implantation failure after in vitro fertilization [J]. Eur Rev Med Pharmacol, 2013, 17 (3): 398-402.
[3]	Zhong Y. Li J. et al. Effect of surgical intervention on the expression of leukemia inhibitory factor and L-selectin ligand in the endometrium of hydrosalpinx patients during the implantation window [J]. Exp Ther Med, 2012, 4 (6): 1027-1031.
[4]	Yan L. Wang A. et al. Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation [J]. Gene, 2012, 506 (2): 350-4.
[5]	Xu B. Sun X. et al. Pinopodes, leukemia inhibitory factor, integrin-beta3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss [J]. Fertil Steril , 2012, 98 (2): 389-95.
[6]	Lopes IM. Baracat MC. et al. Endometrium in women with polycystic ovary syndrome during the window of implantation [J]. Rev Assoc Med Bras, 2012, 57 (6): 702-9.
[7]	Zhioua A. Elloumi H. et al. Morphometric analysis of the human endometrium during the implantation window. Light and transmission electron microscopy study [J]. J Gynecol Obstet Biol Reprod (Paris), 2012, 41 (3): 235-42.
[8]	Petermann T. Ladron A. et al. Polycystic ovary syndrome and pregnancy [J]. Rev Med Chil, 2012, 140 (7): 919-25.
[9]	Bartosch C. Lopes JM. et al. Human endometrium ultrastructure during the implantation window: a new perspective of the epithelium cell types [J]. Reprod, 2011, 18 (6): 525-39.
[10]	Savaris RF. Groll JM. et al. Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles [J]. J Clin Endocrinol Metab, 2011, 96 (6): 1737-46.
[11]	Goto S. Kadowaki T. et al. Stimulation of endometrium embryo transfer can improve implantation and pregnancy rates for patients undergoing assisted reproductive technology for the first time with a high-grade blastocyst [J]. Fertil Steril, 2009, 92 (4): 1264-8.
[12]	Margarit L. Taylor A. et al. MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis [J]. J Clin Endocrinol Metab, 2010, 95 (12): 5320-9.
[13]	Miller DL. Jones CJ. et al. Altered glycosylation in peri-implantation phase endometrium in women with stages III and IV endometriosis [J]. Hum Reprod, 2010, 25 (2): 406-11.
[14]	Zhong Y. Li J., et al. Surgical treatment for hydrosalpinx increases the expression of integrin alphavbeta3 in the endometrium during the implantation window [J]. 2012, 4 (3): 415-418.
[15]	Tan G. Guo W. et al. Temporary reduction and slow recovery of integrin alphanubeta3 in endometrium after uterine arterial embolization [J]. Eur J Obstet Gynecol Reprod Biol, 2012, 160 (1): 66-70.
[16]	Wan PC. Bao ZJ. et al. alphav beta3 Integrin may participate in conceptus attachment by regulating morphologic changes in the endometrium during peri-implantation in ovine [J]. Reprod Domest Anim, 2011, 46 (5): 840-7.
[17]	Kilic S. Hatipoglu T. et al. Impact of high levels of progesterone on alpha (1)-integrin distribution in the endometrium of patients with unexplained infertility [J]. Acta Histochem, 2008, 110 (5): 363-70.
[18]	Boroujerdnia MG. Nikbakht R. Beta3 integrin expression within uterine endometrium and its relationship with unexplained infertility [J]. Pak J Biol, 2008, 11 (21): 2495-9.
[19]	Bukowska D. Kempisty B. et al. Differential expression of epidermal growth factor and transforming growth factor beta isoforms in dog endometrium during different periods of the estrus cycle [J]. Pol J Vet, 2011, 14 (2): 259-64.
[20]	Aghajanova L. Bjuresten K. et al. HB-EGF but not amphiregulin or their receptors HER1 and HER4 is altered in endometrium of women with unexplained infertility [J]. Reprod, 2008, 15 (5): 484-92.
[21]	Ejskjaer K. Sorensen BS. et al. Expression of the epidermal growth factor system in eutopic endometrium from women with endometriosis differs from that in endometrium from healthy women [J]. Gynecol Obstet Invest, 2009, 67 (2): 118-26.
[22]	Veldt BJ. Duarte-Rojo A.et al. Recipient IL28B polymorphism is an important independent predictor of posttransplant diabetes mellitus in kidneytransplant patients with chronic hepatitis C [J]. Am J Transplant, 2019, 12(3): 737-44.
[23]	Sendag F. Akdogan A. et al. Effect of ovarian stimulation with human menopausal gonadotropin and recombinant follicle stimulating hormone on the expression of integrins alpha3, beta1 in the rat endometrium during the implantation period [J]. Eur J Obstet Gynecol Reprod Biol, 2010, 150 (1): 57-60.
[24]	Brosens JJ. Hodgetts A. et al. Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis [J]. Mol Hum Reprod, 2010, 16 (4): 273-85.
[25]	Zhang RJ. Zou LB. et al. Functional expression of large-conductance calcium-activated potassium channels in human endometrium: a novel mechanism involved in endometrial receptivity and embryo implantation [J]. J Clin Endocrinol Metab, 2012, 97 (2): 543-53.
[26]	Cheng SQ. He JL. et al. Characterization of calreticulin expression in mouse endometrium during embryo implantation [J]. Biol Res, 2009, 42 (4): 505-16.
[27]	Szmidt M. Sysa P. et al. Regulation of apoptosis in endometrium preparation for menstruation or embryo implantation [J]. Ginekol Pol, 2010, 81 (11): 856-9.
[28]	Gnainsky Y. Granot I. et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation [J]. Fertil Steril, 2010, 94 (6): 2030-6.
[29]	Zhao Y. Garcia J. et al. The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol [J]. Fertil Steril, 2010, 94 (6): 2264-71.
[30]	Campo S. Campo V. et al. Infertility and adenomyosis [J]. Obstet Gynecol Int, 2012, 48 (7): 132-4.

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APA Style

Wan Yingjun, Ma Fengmei, Zhao Changzhen. (2020). Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window. Science Journal of Public Health, 8(2), 56-62. https://doi.org/10.11648/j.sjph.20200802.15

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ACS Style

Wan Yingjun; Ma Fengmei; Zhao Changzhen. Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window. Sci. J. Public Health 2020, 8(2), 56-62. doi: 10.11648/j.sjph.20200802.15

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AMA Style

Wan Yingjun, Ma Fengmei, Zhao Changzhen. Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window. Sci J Public Health. 2020;8(2):56-62. doi: 10.11648/j.sjph.20200802.15

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@article{10.11648/j.sjph.20200802.15,
  author = {Wan Yingjun and Ma Fengmei and Zhao Changzhen},
  title = {Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window},
  journal = {Science Journal of Public Health},
  volume = {8},
  number = {2},
  pages = {56-62},
  doi = {10.11648/j.sjph.20200802.15},
  url = {https://doi.org/10.11648/j.sjph.20200802.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200802.15},
  abstract = {Objective To study expression of integrin and epidermal growth factor in sterile patients during endometrial implantation window and discuss the relationship between the integrin and epidermal growth factor and endometrial receptivity. Methods: The research objects were divided into 5 groups with 30 women at the normal gestation age, 30 women exhibiting ovulation following PCOS ovulation induction treatment, 26 women exhibiting no ovulation following PCOS ovulation induction treatment, 38 women exhibiting oviduct obstruction, 32 women exhibiting hydrosalpinx. An immunohistochemical method was used to detect the expression of integrin and EGF in sterile women of the five groups of research objects during endometrial implantation window and a statistical analysis was conducted for all detection results. Results The expression level of the integrin in PCOS group is significantly lower than that in the control group and the difference is significant (P0.05); the expression level of the integrin in the hydrosalpinx group is lower than that in the oviduct obstruction group and the difference is significant (P<0.05). EGF is expressed in endometria of various groups of women and its expression is located in cytoplasm of epithelial cells of the endometrial gland. Conclusion Integrin and epidermal growth factor are expressed in endometria of various groups of women in the implantation phase indicating that they may be important regulatory factors for endometrial receptivity and embryonic implantation.},
 year = {2020}
}

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TY  - JOUR
T1  - Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window
AU  - Wan Yingjun
AU  - Ma Fengmei
AU  - Zhao Changzhen
Y1  - 2020/05/29
PY  - 2020
N1  - https://doi.org/10.11648/j.sjph.20200802.15
DO  - 10.11648/j.sjph.20200802.15
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 56
EP  - 62
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20200802.15
AB  - Objective To study expression of integrin and epidermal growth factor in sterile patients during endometrial implantation window and discuss the relationship between the integrin and epidermal growth factor and endometrial receptivity. Methods: The research objects were divided into 5 groups with 30 women at the normal gestation age, 30 women exhibiting ovulation following PCOS ovulation induction treatment, 26 women exhibiting no ovulation following PCOS ovulation induction treatment, 38 women exhibiting oviduct obstruction, 32 women exhibiting hydrosalpinx. An immunohistochemical method was used to detect the expression of integrin and EGF in sterile women of the five groups of research objects during endometrial implantation window and a statistical analysis was conducted for all detection results. Results The expression level of the integrin in PCOS group is significantly lower than that in the control group and the difference is significant (P0.05); the expression level of the integrin in the hydrosalpinx group is lower than that in the oviduct obstruction group and the difference is significant (P<0.05). EGF is expressed in endometria of various groups of women and its expression is located in cytoplasm of epithelial cells of the endometrial gland. Conclusion Integrin and epidermal growth factor are expressed in endometria of various groups of women in the implantation phase indicating that they may be important regulatory factors for endometrial receptivity and embryonic implantation.
VL  - 8
IS  - 2
ER  -

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Author Information

Wan Yingjun

Outpatient Department, Binzhou People's Hospital, Binzhou City, P. R. China
Ma Fengmei

Department of Infectious Diseases, Binzhou People's Hospital, Binzhou City, P. R. China
Zhao Changzhen

Department of Gynecology, Binzhou People's Hospital, Binzhou City, P. R. China

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Plain Text BibTeX RIS

APA Style

Wan Yingjun, Ma Fengmei, Zhao Changzhen. (2020). Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window. Science Journal of Public Health, 8(2), 56-62. https://doi.org/10.11648/j.sjph.20200802.15

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ACS Style

Wan Yingjun; Ma Fengmei; Zhao Changzhen. Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window. Sci. J. Public Health 2020, 8(2), 56-62. doi: 10.11648/j.sjph.20200802.15

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AMA Style

Wan Yingjun, Ma Fengmei, Zhao Changzhen. Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window. Sci J Public Health. 2020;8(2):56-62. doi: 10.11648/j.sjph.20200802.15

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@article{10.11648/j.sjph.20200802.15,
  author = {Wan Yingjun and Ma Fengmei and Zhao Changzhen},
  title = {Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window},
  journal = {Science Journal of Public Health},
  volume = {8},
  number = {2},
  pages = {56-62},
  doi = {10.11648/j.sjph.20200802.15},
  url = {https://doi.org/10.11648/j.sjph.20200802.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200802.15},
  abstract = {Objective To study expression of integrin and epidermal growth factor in sterile patients during endometrial implantation window and discuss the relationship between the integrin and epidermal growth factor and endometrial receptivity. Methods: The research objects were divided into 5 groups with 30 women at the normal gestation age, 30 women exhibiting ovulation following PCOS ovulation induction treatment, 26 women exhibiting no ovulation following PCOS ovulation induction treatment, 38 women exhibiting oviduct obstruction, 32 women exhibiting hydrosalpinx. An immunohistochemical method was used to detect the expression of integrin and EGF in sterile women of the five groups of research objects during endometrial implantation window and a statistical analysis was conducted for all detection results. Results The expression level of the integrin in PCOS group is significantly lower than that in the control group and the difference is significant (P0.05); the expression level of the integrin in the hydrosalpinx group is lower than that in the oviduct obstruction group and the difference is significant (P<0.05). EGF is expressed in endometria of various groups of women and its expression is located in cytoplasm of epithelial cells of the endometrial gland. Conclusion Integrin and epidermal growth factor are expressed in endometria of various groups of women in the implantation phase indicating that they may be important regulatory factors for endometrial receptivity and embryonic implantation.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window
AU  - Wan Yingjun
AU  - Ma Fengmei
AU  - Zhao Changzhen
Y1  - 2020/05/29
PY  - 2020
N1  - https://doi.org/10.11648/j.sjph.20200802.15
DO  - 10.11648/j.sjph.20200802.15
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 56
EP  - 62
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20200802.15
AB  - Objective To study expression of integrin and epidermal growth factor in sterile patients during endometrial implantation window and discuss the relationship between the integrin and epidermal growth factor and endometrial receptivity. Methods: The research objects were divided into 5 groups with 30 women at the normal gestation age, 30 women exhibiting ovulation following PCOS ovulation induction treatment, 26 women exhibiting no ovulation following PCOS ovulation induction treatment, 38 women exhibiting oviduct obstruction, 32 women exhibiting hydrosalpinx. An immunohistochemical method was used to detect the expression of integrin and EGF in sterile women of the five groups of research objects during endometrial implantation window and a statistical analysis was conducted for all detection results. Results The expression level of the integrin in PCOS group is significantly lower than that in the control group and the difference is significant (P0.05); the expression level of the integrin in the hydrosalpinx group is lower than that in the oviduct obstruction group and the difference is significant (P<0.05). EGF is expressed in endometria of various groups of women and its expression is located in cytoplasm of epithelial cells of the endometrial gland. Conclusion Integrin and epidermal growth factor are expressed in endometria of various groups of women in the implantation phase indicating that they may be important regulatory factors for endometrial receptivity and embryonic implantation.
VL  - 8
IS  - 2
ER  -

Copy | Download