Please enter verification code
Confirm
Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease
Science Journal of Public Health
Volume 8, Issue 6, November 2020, Pages: 161-167
Received: Nov. 2, 2020; Published: Nov. 4, 2020
Views 50      Downloads 26
Authors
Fu Xianzhao, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Huang Guang Ming, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Qiu Hai Xian, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Li Chunyan, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Huang Wenhua, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Cao Qiuxia, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Lu Mian, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Article Tools
Follow on us
Abstract
Objective: To investigate the immune regulation of "nourishing Yin and Qi, activating blood circulation and detoxifying" in elderly diabetic patients complicated with acute coronary syndrome (ACS), and analyze its possible mechanisms. Methods: 69 diabetic patients aged 50-75 years and complicated with ACS, from March 2019 to February 2020 in the Department of Cardiology and Traditional Chinese medicine (TCM) in the Affiliated Hospital of Youjiang Medical University for Nationalities were randomly divided into control group (34 cases) and treatment group (35 cases). The control group was given western medicine standardized treatment, while the treatment group were treated with HJJR on the basis of routine Western medical treatment, and the therapeutic course for al1 were 2 months. Before and after treating, in the two groups, the levels of pro-inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor - α (TNF - α) and anti-inflammatory factors [IL-10, adiponectin (ADPN)] were detected. The clinical symptoms of chest tightness, chest pain, attacking frequency and duration, palpitation, shortness of breath, fatigue and the total scores of syndromes in the two groups were detected. At the same time, electrocardiogram (ECG) changes and adverse reactions were observed. Results: Compared with before treatment, after treating, the levels of pro-inflammatory factors CRP, IL-8, TNF - α in the two groups were evidently decreased, while the anti-inflammatory factors IL-10 and ADPN were obviously increased, but the changes in the treatment group were more significant (all P<0.05); the scores of frequency chest tightness and chest pain in both groups were decreased, while the duration of chest tightness and chest pain, fatigue and total score of TCM syndromes in the treatment group were significantly lower than those in the control group (all P<0.05); the number of ST down segment, T-wave flattening, T-wave inversion in ECG were significantly lower than before treatment, with more obviously increased in the treatment group, but no statistically significant. No other adverse reactions were found in the two groups during the medication. Conclusion: HJJR can significantly reduce the levels of CRP, IL-8, TNF - α, and increase the levels of IL-10 and ADPN in the serum of diabetic elderly patients complicated with ACS, suggesting that the effect of “nourishing yin and Qi, activating blood circulation and detoxifying” can regulate the balance mechanism of pro-inflammatory and anti-inflammatory factors, and bring into the protective effect on elderly diabetic patients with ACS.
Keywords
Pro-inflammatory Cytokines, Anti-inflammatory Cytokines, Elderly Diabetes, Acute Coronary Syndrome, Huoxue Jiedu Jiangtang Recipe
To cite this article
Fu Xianzhao, Huang Guang Ming, Qiu Hai Xian, Li Chunyan, Huang Wenhua, Cao Qiuxia, Lu Mian, Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease, Science Journal of Public Health. Vol. 8, No. 6, 2020, pp. 161-167. doi: 10.11648/j.sjph.20200806.12
References
[1]
CHEN Yuanyuan, CHEN Yafen, SUN Xueran, et al. Regulation mechanism of AGEs on FSTL1 expression in diabetes with atherosclerosis. International Journal of Cardiovascular Disease, 2019, 46 (1): 31-35.
[2]
Itariu B K, Stulnig T M. Autoimmune aspects of type 2 diabetes mellitus a mini-review [J]. Gerontology, 2014, 60: 189-196.
[3]
ZHONG Qiaoqing, ZHU Lingyan, ZHANG Guogang, et al. Atherosclerotic cardiovascular disease in diabetes--mechanisms, clinical represent and management. Chinese Journal of Cardiovascular Review, 2018, 16 (12): 1069-1072.
[4]
Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol, 2011, 11: 98-107.
[5]
ZHU Yun-qing, HU Yun, MAO Xiao-ming. The research progress of immune disorders in Type 2 diabetes mellitus. Chinese Journal of Diabetes, 2015, 23 (9): 859-861.
[6]
Zhu Dalong; Mu Yiming. Expert consensus on glucose-lowering pharmacotherapies in Chinese adults with type 2 diabetes and cardiovascular disease or chronic kidney disease. Chinese Journal of Endocrinology and Metabolism, 2020, 6: 458-468.
[7]
FU Xian-zhao, XU Jing, HUANG Wen-hua, et al. Strategy of Stasis-resolving and Detoxification on Diabetic Coronary Heart Disease [J]. JETCM, 2014, 23 (11): 2024-2027.
[8]
Cardiovascular branch of Chinese Medical Association, Editorial board of Chinese Journal of cardiovascular disease. Unstable angina and non-ST-elevation myocardial infarction guidelines for diagnosis and treatment. Chin J Cardiol, 2007, 35 (4): 295-304.
[9]
Cardiovascular branch of Chinese Medical Association, Editorial board of Chinese Journal of cardiovascular disease. 2019 Chinese Society of Cardiology (CSC) guidelines for the diagnosis and management of patients with ST-segment elevation myocardial infarction. Chin J Cardiol, 2019, 47 (10): 766-783.
[10]
Diabetes branch of Chinese Medical Association. Guidelines for the prevention and treatment of type 2 diabetes in China. Chinese Journal of diabetes. 2018, 10 (1): 4-65.
[11]
Zheng Xiaoyi. the new guiding principles of Chinese medicine for clinical research. BeiJing: China Medical Science and Technology Publishing House, 2002: 68-73.
[12]
Shen Ying, Ding Fenghua, Lu Lin, Zhang Ruiyan, Shen Weifeng. Blood pressure management in diabetic patients with coronary artery disease. Chinese Journal of Cardiology, 2020, 1: 5-9.
[13]
Wan Chunling, Yang Yaru, Jiao Yahui. Clinical analysis of adverse cardiovascular events in patients with acute coronary syndrome complicated with type 2 diabetes mellitus. J Clin Psychosom Dis, 2018, 24 (4): 20-22.
[14]
Hong tianpei, Mu yiming, Zhu, dalong. Intervention for adults with pre-diabetes: A Chinese expert consensus. Chinese Journal of Endocrinology and Metabolism, 2020, 5: 371-380.
[15]
XIAO Jian-yong, ZHANG He-nan, CAO Lu. An analysis of relationship between the severity of coronary artery lesion and risk factors of cardiovascular events in Tianjin. Chinese Critical Care Medicine, 2013, 25 (11): 650-654.
[16]
PENG Xiao-ren, ZHAO Yan-fang, ZOU Da-jin. The role of diabetes mellitus as a risk factor of acute myocardial infarction. Chinese Critical Care Medicine, 2011, 23 (6): 322-327.
[17]
CZHANG Zengping, WANG Weijia, KONG Yina, WANG Congrui. orrelation between the stability of carotid artherosclerotic plaque and the levels of serum adopinectin and IL-8 in patients with acute cerebral infraction. J Xuzhou Med Univ 2, 2019, 39 (4): 289-292.
[18]
Hu H, Wang C, Jin Y, et al. Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells. Inflammation. 2019 Feb; 42 (1): 64-80. doi: 10.1007/s10753-018-0873-9.
[19]
Wang Ying, Wang Aihua, Tian Tian. Correlation of endothelin-1, adiponectin, C-reactive protein and related metabolic indexes in type 2 diabetes mellitus with atherosclerosis. Guangdong Medical Journal, 2019, 40 (7): 1020-1024.
[20]
DANG Jingyi, HAO Qimeng, JIANG Na, et al. Relationship between serum lipoprotein (a), β2-microglobulin and tumor necrosis factor-α levels and degree of coronary artery lesion in patients with acute coronary syndrome. Chin J Arterioscler, 2020, 28 (8): 702-706.
[21]
SUN Jun, ZHENG Jiwei, JIA Fan. The relationship between serum IL-6 level of patients with type 2 diabetic mellitus and carotid atherosclerosis. Inr J Lab Med, 2018, 39 (5): 548-554.
[22]
Fu Xianzhao, Huang Zhenfeng, Huang Wenhua, et al. Review and Prospect of the Preventive Effect of “Supplementing Qi and Nourishing Yin, Activating Blood Circulation and Detoxifying” on Diabetes Mellitus Complicated with Acute Coronary Syndrome. [J]. Chin J TCM WM Crit Care, 2017, 24 (5): 547-551.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186