Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease
Science Journal of Public Health
Volume 8, Issue 6, November 2020, Pages: 161-167
Received: Nov. 2, 2020;
Published: Nov. 4, 2020
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Fu Xianzhao, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Huang Guang Ming, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Qiu Hai Xian, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Li Chunyan, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Huang Wenhua, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Cao Qiuxia, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
Lu Mian, Clinic Medical College, Youjiang Medical University for Nationalities, Baise, China
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Objective: To investigate the immune regulation of "nourishing Yin and Qi, activating blood circulation and detoxifying" in elderly diabetic patients complicated with acute coronary syndrome (ACS), and analyze its possible mechanisms. Methods: 69 diabetic patients aged 50-75 years and complicated with ACS, from March 2019 to February 2020 in the Department of Cardiology and Traditional Chinese medicine (TCM) in the Affiliated Hospital of Youjiang Medical University for Nationalities were randomly divided into control group (34 cases) and treatment group (35 cases). The control group was given western medicine standardized treatment, while the treatment group were treated with HJJR on the basis of routine Western medical treatment, and the therapeutic course for al1 were 2 months. Before and after treating, in the two groups, the levels of pro-inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor - α (TNF - α) and anti-inflammatory factors [IL-10, adiponectin (ADPN)] were detected. The clinical symptoms of chest tightness, chest pain, attacking frequency and duration, palpitation, shortness of breath, fatigue and the total scores of syndromes in the two groups were detected. At the same time, electrocardiogram (ECG) changes and adverse reactions were observed. Results: Compared with before treatment, after treating, the levels of pro-inflammatory factors CRP, IL-8, TNF - α in the two groups were evidently decreased, while the anti-inflammatory factors IL-10 and ADPN were obviously increased, but the changes in the treatment group were more significant (all P<0.05); the scores of frequency chest tightness and chest pain in both groups were decreased, while the duration of chest tightness and chest pain, fatigue and total score of TCM syndromes in the treatment group were significantly lower than those in the control group (all P<0.05); the number of ST down segment, T-wave flattening, T-wave inversion in ECG were significantly lower than before treatment, with more obviously increased in the treatment group, but no statistically significant. No other adverse reactions were found in the two groups during the medication. Conclusion: HJJR can significantly reduce the levels of CRP, IL-8, TNF - α, and increase the levels of IL-10 and ADPN in the serum of diabetic elderly patients complicated with ACS, suggesting that the effect of “nourishing yin and Qi, activating blood circulation and detoxifying” can regulate the balance mechanism of pro-inflammatory and anti-inflammatory factors, and bring into the protective effect on elderly diabetic patients with ACS.
Pro-inflammatory Cytokines, Anti-inflammatory Cytokines, Elderly Diabetes, Acute Coronary Syndrome, Huoxue Jiedu Jiangtang Recipe
To cite this article
Huang Guang Ming,
Qiu Hai Xian,
Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease, Science Journal of Public Health.
Vol. 8, No. 6,
2020, pp. 161-167.
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