The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis
Science Journal of Public Health
Volume 8, Issue 2, March 2020, Pages: 19-35
Received: Jan. 9, 2020; Accepted: Jan. 27, 2020; Published: Mar. 10, 2020
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Authors
Changchun Shi, Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China
Meng Peng, Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China
Yingying Du, Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China
Wenxing Li, Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China
Yonghan Hu, Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China
Tingting Wu, Department of Health Management, Medical College of Hangzhou Normal University, Hangzhou city, China
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Abstract
Objective: This research is aimed to systematically evaluate the efficacy and safety of Chinese plus Western Medicine treatment for Childhood purpuric nephritis by Meta-analysis, in order to improve the cure rate and reduce adverse reactions of this disease, then provide guidance for clinical medication. Methods: There are six major databases including CNKI, Pubmed, Embase, World Wide Database, Web of science and Science Direct retrieved through the Internet, and the randomized-controlled trials of the combined therapy for Childhood purpuric nephritis published both in Chinese and English from the 1999 to October 2019 were collected. Meta-analysis by R software 3.5.0 was adopted to analyze the effective index and adverse effect. Results: In total 92 papers of randomized-controlled clinical studies were enrolled. HSPN children treated with combined therapy demonstrated a significant increase in total effective rate (RR=1.19; 95%CI (1.16–1.21), P<0.001) when compared with Western medicine alone. Our study also found that Chinese plus Western medicine had an advantage on decreasing 24-hour urine protein (WMD=-0.47; 95%CI (-0.53,-0.41); p<0.001) and urine erythrocyte count (WMD=-8.88; 95%CI (-9.80,-7.96); p<0.001) when compared with Western medicine. Children seemed to benefit more from combined treatment in the adverse effect (RR=0.64; 95%CI (0.46, 0.87); p<0.01). Conclusions: Integrated Chinese plus Western medicine treatment was effective for Childhood purpuric nephritis, which may be a superior alternative for HSPN. Nevertheless, long-term, high-quality and multicenter RCTs are required to make the results more convincing.
Keywords
Chinese Plus Western Medicine, Childhood Purpuric Nephritis, Efficacy and Safety, Randomized-Controlled Trials, Meta-Analysis
To cite this article
Changchun Shi, Meng Peng, Yingying Du, Wenxing Li, Yonghan Hu, Tingting Wu, The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis, Science Journal of Public Health. Vol. 8, No. 2, 2020, pp. 19-35. doi: 10.11648/j.sjph.20200802.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Zaffanello M, Brugnara M, Franchini M, et al. Adjuvant treatments for Henoch-Schönlein purpura nephritis in children: A systematic review [J]. Current Therapeutic Research. 2009; 70 (3): 254-265.
[2]
Kiryluk K, Moldoveanu Z, Sanders J T, et al. Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schonlein purpura nephritis [J]. Kidney Int. 2011; 80 (1): 79-87.
[3]
Rigante D, Castellazzi L, Bosco A, et al. Is there a crossroad between infections, genetics, and Henoch–Schönlein purpura? [J]. Autoimmunity Reviews. 2013; 12 (10): 1016-1021.
[4]
Wang X, Zhang L, Wang Y, et al. Gut microbiota dysbiosis is associated with Henoch-Schönlein Purpura in children [J]. International Immunopharmacology. 2018; 58: 1-8.
[5]
Dandan D H Y X. Effects of Chinese herbs in children with Henoch-Schonlein purpura nephritis: a randomized controlled trial [J]. JTCM 2014; 34 (1): 15-22.
[6]
Davin J C. Henoch-Schonlein purpura nephritis: pathophysiology, treatment, and future strategy [J]. Clin J Am Soc Nephrol. 2011; 6 (3): 679-689.
[7]
Xie G Q, Wen C P, Fan Y S. Progress in study on synergism and detoxification of Chinese medicine for glucocorticoid [J]. J Tradit Chin Med. 2011; 31 (3): 163-168.
[8]
Zhou YH, Dong XM. TCM syndrome differentiation rule of purpura nephritis in children based on consensus method [J]. Chinese Medical Guide, 2011; 08: 128-129.
[9]
Yi ZW. Interpretation of evidence-based guidelines for the diagnosis and treatment of purpura nephritis in children [J]. Pediatrics in Combination with Chinese and western medicine, 2010; 04: 289-291.
[10]
Lu XD, Wu S, Fu SD. Effects of invigorating spleen and cooling blood and activating blood on hemorheology and lymphocyte immunity in children with purpura nephritis [J]. Liaoning journal of traditional Chinese medicine. 2019; 04: 745-748.
[11]
Yi HL. Effect of huoxue huayu decoction on infantile purpura nephritis [J]. Journal of shanxi university of traditional Chinese medicine. 2019; 02: 108-110.
[12]
Qin YF, li GP. Clinical observation on treating children with purpura nephritis with blood heat and blood stasis with modified xijiao dihuang decoction [J]. Chinese journal of experimental dosage. 2019; 02: 144-149.
[13]
Niu DC. Clinical study of tripterygium wilfordii polyglycoside combined with high-dose methylprednisolone intravenous shock in 46 children with allergic purpura nephritis [J]. Northern pharmacy. 201; 01: 62-63.
[14]
Zhu W. Therapeutic effect of tripterygium wilfordii polyglycoside on children with purpura nephritis and its effect on immune function [J]. Guizhou medicine. 2019; 03: 448-449.
[15]
Ma L, Yuan XF, Li XY, et al. Clinical observation of qingre liangxue huayu decoction in the treatment of infantile purpura nephritis [J]. Chinese medicine guide. 2019; 18: 168-169.
[16]
Huo LJ, Wang K, Bai JX, et al. Clinical efficacy and safety analysis of shenyan kangfu tablet combined with hormone in the treatment of children with purpura nephritis [J]. Medical research and education. 2019; 02: 28-32.
[17]
Ding LJ. Clinical effect of qingre liangxue jiedu prescription on infantile allergic purpura nephritis and its effect on coagulation mechanism [J]. Chinese journal of pediatrics. 2019; 02: 60-63.
[18]
Li Y, Jie SY, huang Y. Effects of bailing capsule therapy on chemochemic protein-1, microalbuminuria and 24 h urine protein quantification in children with purpura nephritis [J]. Medical equipment. 2018; 13: 97-98.
[19]
Huang GC, Sun YN, Lu GN. Effect of tripterygium wilfordii polyglycoside combined with qingre zhixue fang and xiangdan injection in the treatment of children with purpura nephritis [J]. Journal of integrated traditional Chinese and western medicine, 2018, 27; 5: 527-529.
[20]
Liu XS, Da CS. Clinical effect of shipi decoction combined with western medicine in the treatment of purpura nephritis in children [J]. Clinical medicine research and Practice. 2018 (18): 129-130.
[21]
Wu H J. Effect and side effects of glucocorticoid combined with tripterygium wilfordii polyglycoside on purpura nephritis [J]. Huaihai med. 2018 (03): 354-356.
[22]
Huang XH, Hu B. Therapeutic effect of yupingfeng granules combined with double impact therapy on children with severe purpura nephritis [J]. Contemporary medicine. 2018; 21: 73-75.
[23]
Yang QY, Lai ZW, Liu GF. Clinical efficacy of tripterygium wilfordii polyglycoside (TWP) in the treatment of infantile purpura nephritis (HSPN) and its effect on immune function in children [J]. Contemporary medicine. 2017; 29: 40-42.
[24]
Wang HN. Effect of tripterygium wilfordii polyglycoside on purpura nephritis [J]. Electronic journal of clinical medicine. 2017; 81: 15986-15988.
[25]
Zhang L. Clinical analysis of glucocorticoid combined with tripterygium wilfordii glycoside in the treatment of infantile purpura nephritis [J]. Medical theory and practice. 2017; 02: 243-245.
[26]
Liu DF. Clinical study of glucocorticoid combined with tripterygium wilfordii polyglycoside in the treatment of children with purpura nephritis [J]. North China pharmaceutical science. 2017; 07: 74-75.
[27]
Liu XG, Shao Q, Liu P. Effects of bailing capsule adjuvant therapy on urinary McP-1, mAlb and 24h urine protein in children with purpura nephritis [J]. Chinese pharmacists. 2016; 07: 1305-1307.
[28]
Li J. Clinical observation of low molecular weight heparin combined with tripterygium wilfordii in the treatment of children with allergic purpura nephritis [J]. Henan medical research. 2016; 04: 719-720.
[29]
Sun ZH. Clinical study of fushen decoction in the treatment of children with allergic purpura nephritis [J]. Contemporary medicine. 2016; 14: 156-157.
[30]
Zhao QW. Effect of huangkui capsule on children with purpura nephritis [J]. Chinese medical guide. 2016; 13: 185-186.
[31]
He JM. Clinical observation on the treatment of 36 cases of allergic purpura nephritis in children with blood-heat blocking collatulosus combined with western medicine [J]. Journal of Pediatrics of Traditional Chinese Medicine. 2016; 05: 52-55.
[32]
Gu MM. Effect of liangxue xiaobian granule combined with pidomod on the treatment of wind-heat wound collateral-type allergic purpura nephritis in children and its effect on immune function [J]. Modern journal of integrated Chinese and western medicine. 2016; 32: 3552-3554.
[33]
Liu XY. To investigate the clinical efficacy and safety of tripterygium wilfordii polyglycoside combined with glucocorticoid in the treatment of children with purpura nephritis [J]. World latest medical information digest. 2016; 58: 80-83.
[34]
Yin HW, Wang K. Clinical analysis of glucocorticoid combined with tripterygium wilfordii in the treatment of children with purpura nephritis [J]. Medical BBS. 2016; 10: 141-142.
[35]
Zhang XP. Xiaodian empirical prescription for treating purple blemish nephritis in children with blood heat and blood stasis [D]. Anhui university of traditional Chinese medicine, 2016.
[36]
Liu FJ. Treatment analysis of children with nephrotic syndrome purpura nephritis with integrated Chinese and western medicine [J]. Journal of chronic diseases. 2015, 16 (05): 524-527
[37]
Lu W. Effect of huaiqi huang granules on serum cytokines in children with allergic purpura nephritis [J]. China pharmaceutical industry. 2015; 18: 47-49.
[38]
Zhang SS, Zhang Y. Clinical observation of tripterygium wilfordii polyglycoside and prednisone combined with traditional Chinese medicine in the treatment of children with allergic purpura nephritis [J]. Journal of armed police logistics college (medical edition). 2015; 05: 389-390.
[39]
Sun ZM, Wang H, Wei W, et al. Effects of tripterygium wilfordii polyglycoside combined with benapril and heparin on urine protein and urine erythrocyte level in children with allergic purpura nephritis [J]. Chinese modern doctor. 2015; 28: 69-71.
[40]
Zhao F, Liu W. Clinical observation of tripterygium wilfordii polyglycoside combined with glucocorticoid in the treatment of children with purpura nephritis [J]. Chinese journal of integrated traditional and western medicine nephropathy. 2015; 09: 822-823.
[41]
Liu BZ. Taohong siwu decoction for treatment of purpura nephritis clinical analysis [J]. World latest medical information digest. 2015; 76: 83-84.
[42]
Wu HM. Effect of danshen ligustrazine injection on children with purpura nephritis [J]. Contemporary medical review. 2015; 14: 269-270.
[43]
Lin SX. Therapeutic effect of integrated Chinese and western medicine on children with purpura nephritis [J]. Journal of integrated Chinese and western medicine cardiovascular diseases electronic. 2015; 09: 34-35.
[44]
Mao GR. Treatment of 32 children with allergic purpura nephritis from spleen [J]. Zhejiang journal of traditional Chinese medicine. 2014; 06: 440.
[45]
Guo WG. Effect of danshen ligustrazine on serum endothelin-1 in children with purpura nephritis [J]. Guangming traditional Chinese medicine. 2014; 04: 785-786.
[46]
Qiu XY. Clinical analysis of low molecular weight heparin and compound danshen injection in the treatment of children with allergic purpura nephritis [J]. Medical review. 2014; 12: 2269-2271.
[47]
Peng YH, Deng LL. Effect of huaiqi huang granules on the treatment of allergic purpura nephritis and its effect on cytokines in serum [J]. Journal of community medicine. 2014; 20: 10-12.
[48]
Xiang M. Effects of glucocorticoid and tripterygium wilfordii on children with purpura nephritis [J]. J J med. 2014; 17: 25-27.
[49]
Li BN. Efficacy analysis of tripterygium wilfordii polyglycoside in the treatment of children with allergic purpura nephritis [J]. Clinical medicine. 2014; 01: 122.
[50]
Li P, HuangFu CR, Tang CH. Therapeutic effect of tripterygium wilfordii polyglycoside on children with purpura nephritis and its effect on immune function [J]. Chinese journal of clinical pharmacology. 2014; 10: 895-897.
[51]
Wang P. Clinical observation of xiaobanshenfu decoction in the treatment of hypersensitive purpura nephritis in children with blood-heat injury [D]. Heilongjiang academy of traditional Chinese medicine, 2014.
[52]
Wu H, Chen XH, Zhou S, et al. Efficacy and safety evaluation of low-dose tripterygium wilfordii polyglycoside combined with glucocorticoid in the treatment of children with purpura nephritis [J]. Chinese rural health service management. 2014; 01: 104-107.
[53]
Wang J, Diao LL, Liu L. Clinical observation on treating purpura nephritis with yishen jianpi clearing damp huoxue decoction [J]. Chinese medicine clinical journal. 2014; 04: 379-381.
[54]
Wu YH. Treatment of children with purpura nephritis with integrated Chinese and western medicine [J]. Everybody's health (academic edition). 2014; 24: 52-53.
[55]
Han DX. Clinical observation of 38 cases of children with allergic purpura nephritis treated by integrated Chinese and western medicine [J]. Chinese folk medicine. 2014; 22: 42-44.
[56]
Gong BX. Therapeutic effect of integrated Chinese and western medicine on children with allergic purpura nephritis [J]. Modern journal of integrated Chinese and western medicine. 2014; 14: 1557-1558.
[57]
Cheng L. Treatment of children with purpura nephritis with integrated Chinese and western medicine: 38 cases [J]. Modern distance education of Chinese medicine. 2014; 10: 60-69.
[58]
Liu YZ. Therapeutic effect of integrated Chinese and western medicine on children with purpura nephritis [J]. Clinical medicine. 2014; 05: 121-123.
[59]
Shi ZM. Clinical effect of integrated Chinese and western medicine on children with purpura nephritis [J]. Asia-pacific traditional medicine. 2014; 16: 52-53.
[60]
Zhao YX, Guo JY. Treating 32 cases of purpura nephritis with invigorating spleen, invigorating qi, cooling blood and activating blood formula combined with western medicine [J]. Shaanxi journal of traditional Chinese medicine. 2013; 11: 1495-1496.
[61]
Huang T. Tanshinone II A sulfonate with glucocorticoid therapy of children with purpura nephritis clinical observation [J]. Journal of contemporary Chinese medicine. 2013; 28: 80-81.
[62]
He GX. Effect of kangmin xiaopan decoction combined with western medicine in the treatment of allergic purpura [J]. China practical medicine. 2013; 21: 165-166.
[63]
Zeng LL. Efficacy of tripterygium wilfordii polyglycoside combined with hormone in the treatment of children with purpura nephritis and its effect on coagulation function [J]. Journal of liaoning university of traditional Chinese medicine. 2013; 06: 182-183.
[64]
Yan HQ, Zeng J. Clinical observation of tripterygium wilfordii polyglycoside in the treatment of children with purpura nephritis [J]. Chinese contemporary medicine. 2013; 28: 86-87.
[65]
Jiang JP, Ge DF. Curative effect of qingrezhuyu decoction combined with western medicine in the treatment of 34 cases of purpura nephritis [J]. Chinese journal of acute medicine. 2013; 12: 2133-2134.
[66]
Deng BZ. Xiaodian fang treatment of 32 cases of allergic purpura nephritis [J]. Journal of practical Chinese medicine. 2013; 11: 928.
[67]
Li MY. Treatment of children with purpura nephritis by integrated Chinese and western medicine [J]. China health industry. 2013; 21: 123-125.
[68]
Jin JW, Wang R. Clinical observation of yuduqing combined with western medicine in the treatment of children with allergic purpura nephritis: 42 cases [J]. Hebei journal of traditional Chinese medicine. 2013; 09: 1410-1416.
[69]
Yuan PZ. Clinical analysis of 35 cases of children with purpura nephritis treated by integrated Chinese and western medicine [J]. Chinese and foreign medical research. 2013; 07: 46-47.
[70]
Wang YJ, Zhang LM, Men GG, et al. Clinical observation of tripterygium wilfordii polyglycoside combined with hormone in the treatment of children with purpura nephritis [J]. Journal of pediatric pharmacy. 2012; 06: 24-26.
[71]
Ji RW. Treatment of 35 cases of allergic purpura nephritis with integrated Chinese and western medicine [J]. Inner Mongolia journal of traditional Chinese medicine. 2012; 04: 27-28.
[72]
Li YE, ZhangTD. Clinical observation on syndrome differentiation in treatment of purpura nephritis [J]. Sichuan journal of traditional Chinese medicine. 2011; 02: 87.
[73]
Chen CL. Efficacy of low molecular weight heparin combined with compound danshen injection in treating children with allergic purpura nephritis [J]. Medical information. 2011; 09: 4886-4887.
[74]
Pang FM. Effect of tripterygium wilfordii polyglycoside on treatment of 34 cases of purpura nephritis [J]. Hainan med. 2011; 10: 84-85.
[75]
Pei HB, Ji HP. 37 cases of children with allergic purpura nephritis treated by shengyang sanhuo decoction combined with western medicine [J]. Journal of practical Chinese medicine internal medicine. 2011; 08: 61-62.
[76]
Wang CF, Xia Y, Liu JC. Therapeutic effect of yishen granules on children with allergic purpura nephritis [J]. Guangming traditional Chinese medicine. 2011; 06: 1143-1144.
[77]
Guo YH, Jin D. 30 cases of children with purpura nephritis treated by integrated Chinese and western medicine [J]. Western Chinese medicine. 2011; 10: 71-73.
[78]
Li JC, Gao YX. Therapeutic effect of integrated Chinese and western medicine on 30 cases of allergic purpura [J]. Shanxi journal of medicine. 2011; 10: 1009-1010.
[79]
Zhao ZY, Qi YF. Therapeutic effect of integrated Chinese and western medicine on children with purpura nephritis: 40 cases [J]. Pediatrics of integrated Chinese and western medicine, 2011; 02: 161-162.
[80]
Peng HP. Treatment of 50 cases of allergic purpura nephritis with integrated Chinese and western medicine [J]. Guangming traditional Chinese medicine. 2011; 06: 1213-1214.
[81]
Zhao YD. Clinical analysis and study of integrated Chinese and western medicine in the treatment of children with allergic purpura nephritis [D]. Lanzhou university, 2011.
[82]
Hao JJ. Treatment of children with nephrotic syndrome purpura nephritis with integrated Chinese and western medicine [J]. Chinese and foreign medical treatment. 2011; 01: 53-55.
[83]
Lu J, Liu X. Treatment of infantile purpura nephritis with integrated Chinese and western medicine [J]. World journal of integrated Chinese and western medicine. 2010; 04: 351.
[84]
Chen ZH. Summary of 38 cases of children with purpura nephritis treated by integrated Chinese and western medicine [J]. Hunan journal of traditional Chinese medicine. 2010; 03: 3-5.
[85]
Yu FM. Clinical observation on 28 cases of purpura nephritis treated by integrated Chinese and western medicine [J]. Chinese community physician. 2010; 08: 116.
[86]
Zhang TD, Li YF. Treatment of 30 cases of purpura nephritis with integrated Chinese and western medicine [J]. Chinese journal of acute medicine. 2010; 04: 667-668.
[87]
Guo QY, Ren XQ. Syndrome differentiation and treatment combined with prednisone for children with nephrotic syndrome purpura nephritis: 42 cases [J]. Shaanxi journal of traditional Chinese medicine. 2009; 07: 798-799.
[88]
Huang QY. Efficacy of low molecular weight heparin combined with tripterygium wilfordii glycoside in the treatment of children with allergic purpura nephritis [J]. Chinese and foreign medical treatment. 2009; 07: 72.
[89]
Chen CB, Wang M, Lu Wei. Effect of cyclophosphamide injection combined with prednisone on children with purpura nephritis [J]. Chinese journal of nephropathy of integrated traditional and western medicine. 2009; 11: 1001-1002.
[90]
Ma XC, Wang LL, Feng JH. Clinical observation of shenyankang in the treatment of children with allergic purpura nephritis [J]. Jilin traditional Chinese medicine. 2009; 10: 845-846.
[91]
Li G, Zhang BQ, Liu ZG. The advantages of combining Chinese and western medicine in the treatment of children with purpura nephritis [J]. Chinese and foreign medical treatment. 2009; 03: 82.
[92]
Huang WY. Clinical observation of 35 cases of children with purpura nephritis treated by integrated Chinese and western medicine [J]. Sichuan journal of traditional Chinese medicine. 2009; 06: 99-100.
[93]
Wu ZC, Zhang Li. Treatment of children with allergic purpura by integrated Chinese and western medicine: 92 cases [J]. Chinese folk medicine. 2009; 14: 70.
[94]
Wang J. Treatment of children with purpura nephritis by integrated Chinese and western medicine [J]. Journal of practical Chinese medicine. 2009; 06: 381-382.
[95]
Wang JL, Luo GX. clinical observation of jiedu huayu decoction in the treatment of allergic purpura nephritis [J]. Chinese journal of traditional Chinese medicine. 2007; 12: 2655-2656.
[96]
Wang YL, Zhang LM, Xin RZ, et al. Clinical observation of tripterygium wilfordii glycosides in treating children with allergic purpura nephritis [J]. Chinese journal of coal industry medicine. 2007; 02: 161-162.
[97]
Fan WW, Jiang XB, Shi ZX, et al. Treatment of children with allergic purpura nephritis by integrated traditional Chinese and western medicine [J]. Hunan journal of traditional Chinese medicine. 2007; 02: 28-30.
[98]
Zhang JP, Xie FP, Long YC. tripterygium wilfordii glycosides in the treatment of children with allergic purpura nephritis [J]. Clinical research. 2006; 06: 952-953.
[99]
Chang WJ, Fang JA. Clinical study of yiqitonglin capsule in the treatment of 60 cases of allergic purpura nephritis [J]. Chinese journal of integrated traditional and western medicine nephropathy. 2006; 08: 424-425.
[100]
Song MS. Xiere xiaopan decoction in the treatment of infantile purpura nephritis [J]. Chinese journal of nephropathy, 2005; 12: 727.
[101]
Mao YY, Wang HP, Zhou QF. Therapeutic effect of integrated Chinese and western medicine on children with purpura nephritis [J]. Journal of shandong university of traditional Chinese medicine. 2004; 01: 41-43.
[102]
Zhang Y, Li A, Wen J, et al. Kidney Injury Molecule-1 Level is Associated with the Severity of Renal Interstitial Injury and Prognosis in Adult Henoch–Schönlein Purpura Nephritis [J]. Archives of Medical Research. 2017; 48 (5): 449-458.
[103]
Sun J. Progress of traditional Chinese medicine treatment of purpura kidney (HSPN) in children [J]. Jilin traditional Chinese medicine (Chin) 2007; 05: 68-69.
[104]
Chen Q, Wu YQ, Li N, et al. Efficacy and safety evaluation of tripterygium wilfordii in the treatment of purpura nephritis in children and meta-analysis [Z]. Nanning, guangxi, China (Chin) 2015; 1.
[105]
Chen Y, Yu L, Zhang Y. Efficacy analysis of cyclosporine A combined with hormone in the treatment of purpura nephritis in children [J]. Journal of clinical and experimental medicine (Chin) 2010; 17: 1294-1295.
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