Please enter verification code
The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management
Science Journal of Public Health
Volume 6, Issue 4, July 2018, Pages: 116-119
Received: Sep. 16, 2018; Published: Sep. 18, 2018
Views 1301      Downloads 97
Zejun Zhou, Otolaryngology Department, the First Affiliated Hospital of Jinan University, Guangzhou, P.R.China
Fang Xu, Medical Examination Department, the First Affiliated Hospital of Jinan University, Guangzhou, P.R.China
Article Tools
Follow on us
Discus the management of Enhanced recovery after surgery,levels and clinical meaning of interleukin IL-18 and IL-6 in peripheral blood of patients with sleep apnea hypopnea syndrome (OSAHS). By ELISA to detect the levels of IL-18 and IL-6 in serum and peripheral blood mononuclear cells (PBMCs) supernatants of OSAHS patients and healthy controls and check the changes in serum IL-18 and IL-6 levels in OSAHS patients before and after Han uvulopalatopharyngoplasty (H-UPPP) treatment. The levels of IL-18 and IL-6 in serum and PBMCs supernatant of OSAHS patients were higher than those of the matched group (P <0.05). The levels of serum IL-18 and IL-6 increased with the severity of OSAHS, and the levels of IL-18 and IL-6 in serum and PBMCs supernatants were positively correlated (P <0.05). After 2 months of H-UPPP, the serum levels of IL-18, IL-6 and the index of respiratory disturbance were significantly lower than before the treatment (P <0. 05). The sleep quality and nocturnal hypoxia were significantly improved, and the lowest oxygen saturation was significantly higher than before the treatment (P <0.05). IL-18 and IL-6 may play an important role in the pathogenesis and prognosis of OSAHS.
ERAS Management, Sleep Apnea, Hypoventilation Syndrome, IL-6, IL-18
To cite this article
Zejun Zhou, Fang Xu, The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management, Science Journal of Public Health. Vol. 6, No. 4, 2018, pp. 116-119. doi: 10.11648/j.sjph.20180604.14
Yilmaz G, Akca A, Aydin N. Enhanced recovery after surgery (ERAS) versus conventional postoperative care in patients undergoing abdominal hysterectomies. Ginekologia polska. 2018; 89(7):351-6.
Tang XM, Tang LYQ, Li JS. [Sparkplug the construction of enhanced recovery after surgery--promote reform of clinic education]. Zhonghua yi xue za zhi. 2018; 98(28):2217-9.
Zhang T, Zhang C, Chen RX, Shao B, Liu GA. Correlation between coronary artery lesion quantitative score and OSAHS and relative risk factors. European review for medical and pharmacological sciences. 2018; 22(5):1415-20.
Zhang H, Yang F, Guo Y, Wang L, Fang F, Wu H, et al. The contribution of chronic intermittent hypoxia to OSAHS: From the perspective of serum extracellular microvesicle proteins. Metabolism: clinical and experimental. 2018; 85:97-108.
Mei HF, Poonit N, Zhang YC, Ye CY, Cai HL, Yu CY, et al. Activating adenosine A1 receptor accelerates PC12 cell injury via ADORA1/PKC/KATP pathway after intermittent hypoxia exposure. Molecular and cellular biochemistry. 2018; 446(1-2):161-70.
Lu HY, Wang W, Zhou Z, Liu CY, Liu Y, Xiao W, et al. Treatment of obstructive sleep apnoea-hypopnea syndrome by mandible advanced device reduced neuron apoptosis in frontal cortex of rabbits. European journal of orthodontics. 2018; 40(3):273-80.
Crosson JA. Enhanced Recovery After Surgery-The Importance of the Perianesthesia Nurse on Program Success. Journal of perianesthesia nursing: official journal of the American Society of PeriAnesthesia Nurses. 2018; 33(4):366-74.
Joliat GR, Sauvain MO, Petermann D, Halkic N, Demartines N, Schafer M. Surgical site infections after pancreatic surgery in the era of enhanced recovery protocols. Medicine. 2018; 97(31):e11728.
Estebe JP. Intravenous lidocaine. Best practice & research Clinical anaesthesiology. 2017; 31(4):513-21.
Dumestre DO, Redwood J, Webb CE, Temple-Oberle C. Enhanced Recovery After Surgery (ERAS) Protocol Enables Safe Same-Day Discharge After Alloplastic Breast Reconstruction. Plast Surg (Oakv). 2017; 25(4):249-54.
Taniguchi H, Sasaki T, Fujita H, Kobayashi H, Kawasaki R, Ogata T, et al. Effects of goal-directed fluid therapy on enhanced postoperative recovery: An interventional comparative observational study with a historical control group on oesophagectomy combined with ERAS program. Clinical nutrition ESPEN. 2018; 23:184-93.
Sayed E, Gaballah K, Younis E, Yassen K, El-Einen AK. The effect of intravenous infusion of N-acetyl cysteine in cirrhotic patients undergoing liver resection: A randomized controlled trial. Journal of anaesthesiology, clinical pharmacology. 2017; 33(4):450-6.
Li H, Chen Z. Application of rehabilitation medicine in enhanced recovery after surgery. Journal of Zhejiang University Medical sciences. 2017; 46(6):675-8.
Meccariello G, Cammaroto G, Montevecchi F, Hoff PT, Spector ME, Negm H, et al. Transoral robotic surgery for the management of obstructive sleep apnea: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2017; 274(2):647-53.
Jia L, Fan J, Cui W, Liu S, Li N, Lau WB, et al. Endothelial Cell-Derived Microparticles from Patients with Obstructive Sleep Apnea Hypoxia Syndrome and Coronary Artery Disease Increase Aortic Endothelial Cell Dysfunction. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 43(6):2562-70.
Folk D, D'Agostino M. Transoral robotic surgery vs. endoscopic partial midline glossectomy for obstructive sleep apnea. World journal of otorhinolaryngology - head and neck surgery. 2017; 3(2):101-5.
Al-Abed M, Antich P, Watenpaugh DE, Behbehani K. Phantom study evaluating detection of simulated upper airway occlusion using piezoelectric ultrasound transducers. Computers in biology and medicine. 2017; 89:325-36.
Basunia M, Fahmy SA, Schmidt F, Agu C, Bhattarai B, Oke V, et al. Relationship of symptoms with sleep-stage abnormalities in obstructive sleep apnea-hypopnea syndrome. Journal of community hospital internal medicine perspectives. 2016;6(4):32170.
Patel AV, Hwang D, Masdeu MJ, Chen GM, Rapoport DM, Ayappa I. Predictors of response to a nasal expiratory resistor device and its potential mechanisms of action for treatment of obstructive sleep apnea. Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine. 2011; 7(1):13-22.
Callahan CY, Norman RG, Taxin Z, Mooney AM, Rapoport DM, Ayappa I. Multinight recording and analysis of continuous positive airway pressure airflow in the home for titration and management of sleep disordered breathing. Sleep. 2013; 36(4):535-45F.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186