The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management
Science Journal of Public Health
Volume 6, Issue 4, July 2018, Pages: 116-119
Received: Sep. 16, 2018;
Published: Sep. 18, 2018
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Zejun Zhou, Otolaryngology Department, the First Affiliated Hospital of Jinan University, Guangzhou, P.R.China
Fang Xu, Medical Examination Department, the First Affiliated Hospital of Jinan University, Guangzhou, P.R.China
Discus the management of Enhanced recovery after surgery，levels and clinical meaning of interleukin IL-18 and IL-6 in peripheral blood of patients with sleep apnea hypopnea syndrome (OSAHS). By ELISA to detect the levels of IL-18 and IL-6 in serum and peripheral blood mononuclear cells (PBMCs) supernatants of OSAHS patients and healthy controls and check the changes in serum IL-18 and IL-6 levels in OSAHS patients before and after Han uvulopalatopharyngoplasty (H-UPPP) treatment. The levels of IL-18 and IL-6 in serum and PBMCs supernatant of OSAHS patients were higher than those of the matched group (P <0.05). The levels of serum IL-18 and IL-6 increased with the severity of OSAHS, and the levels of IL-18 and IL-6 in serum and PBMCs supernatants were positively correlated (P <0.05). After 2 months of H-UPPP, the serum levels of IL-18, IL-6 and the index of respiratory disturbance were significantly lower than before the treatment (P <0. 05). The sleep quality and nocturnal hypoxia were significantly improved, and the lowest oxygen saturation was significantly higher than before the treatment (P <0.05). IL-18 and IL-6 may play an important role in the pathogenesis and prognosis of OSAHS.
The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management, Science Journal of Public Health.
Vol. 6, No. 4,
2018, pp. 116-119.
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