Science Journal of Public Health
Volume 4, Issue 5, September 2016, Pages: 387-393
Received: Sep. 7, 2015;
Accepted: Sep. 21, 2015;
Published: Aug. 17, 2016
Views 2733 Downloads 66
Brhanu Teka, Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
Solomon Gebre - Selassie, Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
Tamrat Abebe, Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia
Background. Helicobacter pylori (H. pylori) is recognized as a major human pathogen. Clinical symptoms associated with H. pylori infection have been reported in patients with human immunodeficiency virus (HIV). A high, normal, and a lower sero - prevalence of H. pylori infection in HIV positive patients than negative controls was found in different studies. The aim of this study was to assess the sero - prevalence of H. pylori infection in HIV positive patients and negative controls and determine the impact of CD4 cell count in patients with H. pylori in St. Paul’s General Specialized Hospital in Addis Ababa, Ethiopia. Methods. A comparative cross sectional study was conducted in HIV positive patients and controls with gastrointestinal symptoms using Serology test kit (ACON® H. pylori, USA). All individuals who came to Voluntary Counselling and Testing and Anti - Retroviral Therapy to the Out Patient Department of the hospital were examined for complaints of dyspepsia and those with the complaint were tested for H. pylori. Results. Of the 106 HIV positive subjects, 68 (64.2%) were positive for anti - H. pylori IgG antibodies; and of the 106 HIV negative controls, 52 (49.1%) were positive for anti - H. pylori IgG antibodies (p=0.037). There was no significant difference of H. pylori seroprevalence between relatively higher and lower CD4 cell counts in the HIV positive cases (p>0.05). Conclusion. A significantly higher seroprevalence of H. pylori was demonstrated in the HIV positive subjects. There was no significant difference in the prevalence of H. pylori between different CD4+ cell counts in the HIV positive study group.
Solomon Gebre - Selassie,
Sero - Prevalence of Helicobacter Pylori in HIV Positive Patients and HIV Negative Controls in St. Paul’s General Specialized Hospital, Addis Ababa, Ethiopia, Science Journal of Public Health.
Vol. 4, No. 5,
2016, pp. 387-393.
Versalovic J. (2003). Helicobacter pylori Pathology and Diagnostic Strategies. Am. J Clin Pathol.119: 403-412.
Ostrow B. (2010). Peptic Ulcer Disease-the impact of Helicobacter pylori on management in the developing world. Surgery in Africa Monthly Review. http: //www.ptolemy.ca/members/archives/2007/ulcer/index.htm (Accessed on 28AUG2010).
Blaser MJ. and Berg DE. (2001). Helicobacter pylori genetic diversity and risk of human disease. Journal of Clinical Investigation. 107 (7): 767–773.
Tadege T., Mengistu Y., Desta K., Asrat D. (2005). Seroprevalence of Helicobacter pylori Infection in and its Relationship with ABO Blood Groups. Ethiop.J. Health Dev. 19 (1): 55-59.
Daniel T. Nevin, Christopher J. Morgan, David Y. Graham, Robert M. Genta. (2014). Helicobacter pylori Gastritis in HIV-Infected Patients: A Review. Helicobacter 19: 323–329.
Romanelli F., Smith KM. and Murphy B. S. (2007). Does HIV Infection Alter the Incidence or Pathology of Helicobacter pylori Infection? AIDS patient care and STDs. 21 (12): 908-19.
Marano BJ Jr., Smith F. and Bonauno C. A. (1993). Helicobacter pylori prevalence in acquired immunodeficiency syndrome. Am.J.Gastroenterology. 88: 687-690.
Mach T, Skwara P, Biesiada G, Cieśla A, Macura A. (2007). Morphological changes of the upper gastrointestinal tract mucosa and Helicobacter pylori infection in HIV-positive patients with severe immunodeficiency and symptoms of dyspepsia. Med Sci Monit. 13 (1): CR14-9).
Lichterfeld M., Lorenz C., Nischalke H D., Scheurlen Ch., Sauerbruch T., Rockstroh J K. (2002). Decreased Prevalence of Helicobacter pylori Infection in HIV Patients with AIDS defining Diseases. Z Gastroenterol. 40 (1): 11-14.
Panos GZ., Xirouchakis E., Tzias V., Charatsis G., Bliziotis IA., Doulgeroglou V., Margetis N., Falagas ME. (2007). Helicobacter pylori infection in symptomatic HIV-seropositive and seronegative patients: a case-control study. AIDS Res Hum Retroviruses. 23 (5): 709-12.
Fabris P., Pilotto A., Bozzolaà L., Tositti G., Soffiati G., Manfrin V., De Lalla F. (2002). Serum pepsinogen and gastrin levels in HIV-positive patients: relationship with CD4+ cell count and Helicobacter pylori infection. Aliment Pharmacol Ther.16: 807–811.
Alimohamed F., Lule N., Nyong'o A., Bwayo J; Rana FS. (2002). Prevalence of Helicobacter pylori and endoscopic findings in HIV seropositive patients with upper gastrointestinal tract symptoms at Kenyatta National Hospital, Nairobi. East African Medical journal. 79: 5, 226-231.
Nielsen H., Andersen LP. (2009). Sero-diagnosis of Helicobacter pylori infection in patients with human immunodeficiency virus infection. APMIS. 103, 7-8: 689–692.
Francis N D., Logan R P H., Walker MM., Polson RJ., Boylston A W., Pinching A J., Harris J R W., Baron J H. (1990). Campylobacter pylori in the upper gastrointestinal tract of patients with HIV-1 infection. J Clin Pathol. 43: 60-62.
Luo HB., Hu ZW., Guo JW., (2009). Helicobacter pylori infection in the gastric mucosa of patients with HIV/AIDS in different clinical stages. Journal of southern medical university. 29 (7): 1397-9.
Brenchley JM. and Douek DC (2008). HIV infection and the gastrointestinal immune system. Mucosal Immunol.1: 23–30.
Abbott TC. Prevalence of Helicobacter pylori and its relation to cytotoxin-associated gene A status in HIV positive and negative haematology patients. http://etd.uovs.ac.za/ETD-db//theses/available/etd-09042009-110536/unrestricted/AbbottTC.pdf (2007) (accessedon 4SEP2010).
Lionetti P., Amarri S., Silenzi F., Galli L., Cellini M., de Martino M., Vierucci A. (1999). Prevalence of Helicobacter pylori Infection Detected by Serology and 13C-Urea Breath Test in HIV-1 Perinatally Infected Children. Journal of Pediatric Gastroenterology & Nutrition. 28 (3): 301-306.
Boyle (2001). GI and Hepatic Diseases Associated with HIV: HIV-Infected Patients Have a High Rate of H. pylori Infection. AIDS Read, 11 (7): 354-5, 359-61, 363.