American Journal of Laboratory Medicine

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Oxidative Stress and Human Psoriasis Diseases

Received: 15 July 2020    Accepted: 28 July 2020    Published: 10 August 2020
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Abstract

Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (p<0.001) as well as Oxidative Stress Index (p<0.001) in psoriasis patients as compared to controls and positively correlated with severity and duration of the disease. Total Anti-oxidant capacity levels were significantly (p<0.001) lower in patients than in controls and negatively correlated with severity and duration of the disease. Conclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.

DOI 10.11648/j.ajlm.20200504.16
Published in American Journal of Laboratory Medicine (Volume 5, Issue 4, July 2020)
Page(s) 118-124
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Total Oxidant Capacity, Total Antioxidant Capacity, Oxidative Stress Index, Psoriasis

References
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Author Information
  • Department of Biochemistry, Mekelle University, Mekelle, Ethiopia

  • Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia

  • Department of Dermatology, Addis Ababa University, Addis Ababa, Ethiopia

  • Department of Microbiology, Parasitology and Immunology, Addis Ababa University, Addis Ababa, Ethiopia

  • Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia

  • Department of Biochemistry, Mekelle University, Mekelle, Ethiopia

  • Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia

Cite This Article
  • APA Style

    Asrat Endrias, Menakath Menon, Mihretu Wodeyes, Tamrat Abebe, Mohammed Mehdi, et al. (2020). Oxidative Stress and Human Psoriasis Diseases. American Journal of Laboratory Medicine, 5(4), 118-124. https://doi.org/10.11648/j.ajlm.20200504.16

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    ACS Style

    Asrat Endrias; Menakath Menon; Mihretu Wodeyes; Tamrat Abebe; Mohammed Mehdi, et al. Oxidative Stress and Human Psoriasis Diseases. Am. J. Lab. Med. 2020, 5(4), 118-124. doi: 10.11648/j.ajlm.20200504.16

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    AMA Style

    Asrat Endrias, Menakath Menon, Mihretu Wodeyes, Tamrat Abebe, Mohammed Mehdi, et al. Oxidative Stress and Human Psoriasis Diseases. Am J Lab Med. 2020;5(4):118-124. doi: 10.11648/j.ajlm.20200504.16

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  • @article{10.11648/j.ajlm.20200504.16,
      author = {Asrat Endrias and Menakath Menon and Mihretu Wodeyes and Tamrat Abebe and Mohammed Mehdi and Ezra Belay and Daniel Seifu},
      title = {Oxidative Stress and Human Psoriasis Diseases},
      journal = {American Journal of Laboratory Medicine},
      volume = {5},
      number = {4},
      pages = {118-124},
      doi = {10.11648/j.ajlm.20200504.16},
      url = {https://doi.org/10.11648/j.ajlm.20200504.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajlm.20200504.16},
      abstract = {Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (pConclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Oxidative Stress and Human Psoriasis Diseases
    AU  - Asrat Endrias
    AU  - Menakath Menon
    AU  - Mihretu Wodeyes
    AU  - Tamrat Abebe
    AU  - Mohammed Mehdi
    AU  - Ezra Belay
    AU  - Daniel Seifu
    Y1  - 2020/08/10
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ajlm.20200504.16
    DO  - 10.11648/j.ajlm.20200504.16
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
    SP  - 118
    EP  - 124
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20200504.16
    AB  - Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (pConclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.
    VL  - 5
    IS  - 4
    ER  - 

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