American Journal of Laboratory Medicine

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Tracheal Aspirate Cytology of 43 High-Risk Neonates to Predict Bronchopulmonary Dysplasia Early

Received: 19 June 2019    Accepted: 01 July 2019    Published: 12 July 2019
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Abstract

The main goal of this study was to assess the cytological evaluation of tracheal aspirate, in order to predict the early diagnosis of bronchopulmonary dysplasia (BPD) in high-risk babies during mechanical ventilation. Method: Samples from 43 infants (aged < 34 weeks and weighed ≤ 1500 g) were examined cytologically; who were admitted to Pediatric Intensive Care Units and diagnosed as respiratory distress syndrome by clinical and radiological criteria. Results: Up to 150 tracheal aspirates from 43 infants were examined to demonstrate cytological changes in bronchial epithelial cells that progressed to dysplasia. It was cytologically designated Class III. According to cytological criteria, all intubated infants had reactive hyperplastic and metaplastic epithelial changes. There were dysplastic changes in 23 out of 33 who developed BPD and 7 out of 40 who had a normal outcome. The variation between the numbers of neonates that had dysplasia in the BPD and the non-BPD group was significant (P < 0.002 by chi-square test). Conclusion: In order to monitor the development of lung injury and repair, tracheal aspirate cytology is simple, non-invasive and fast. Cytological monitoring of respiratory distress infants may be helpful in the early diagnosis and prognosis of the developing BPD. Evaluating new BPD preventive treatment schemes may also be valuable.

DOI 10.11648/j.ajlm.20190403.13
Published in American Journal of Laboratory Medicine (Volume 4, Issue 3, May 2019)
Page(s) 65-69
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Bronchopulmonary Dysplasia (BPD), Cytology, Microscopic, Neonates, Predict, Tracheal Aspirate

References
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Author Information
  • Department of Pathology, Al Galaa Teaching Hospital, General Organization of Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt

  • Department of Pathology, Al Galaa Teaching Hospital, General Organization of Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt

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    Sahar Ali Mohamed, Hossam Eldin Mohammed. (2019). Tracheal Aspirate Cytology of 43 High-Risk Neonates to Predict Bronchopulmonary Dysplasia Early. American Journal of Laboratory Medicine, 4(3), 65-69. https://doi.org/10.11648/j.ajlm.20190403.13

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    Sahar Ali Mohamed; Hossam Eldin Mohammed. Tracheal Aspirate Cytology of 43 High-Risk Neonates to Predict Bronchopulmonary Dysplasia Early. Am. J. Lab. Med. 2019, 4(3), 65-69. doi: 10.11648/j.ajlm.20190403.13

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    AMA Style

    Sahar Ali Mohamed, Hossam Eldin Mohammed. Tracheal Aspirate Cytology of 43 High-Risk Neonates to Predict Bronchopulmonary Dysplasia Early. Am J Lab Med. 2019;4(3):65-69. doi: 10.11648/j.ajlm.20190403.13

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  • @article{10.11648/j.ajlm.20190403.13,
      author = {Sahar Ali Mohamed and Hossam Eldin Mohammed},
      title = {Tracheal Aspirate Cytology of 43 High-Risk Neonates to Predict Bronchopulmonary Dysplasia Early},
      journal = {American Journal of Laboratory Medicine},
      volume = {4},
      number = {3},
      pages = {65-69},
      doi = {10.11648/j.ajlm.20190403.13},
      url = {https://doi.org/10.11648/j.ajlm.20190403.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajlm.20190403.13},
      abstract = {The main goal of this study was to assess the cytological evaluation of tracheal aspirate, in order to predict the early diagnosis of bronchopulmonary dysplasia (BPD) in high-risk babies during mechanical ventilation. Method: Samples from 43 infants (aged < 34 weeks and weighed ≤ 1500 g) were examined cytologically; who were admitted to Pediatric Intensive Care Units and diagnosed as respiratory distress syndrome by clinical and radiological criteria. Results: Up to 150 tracheal aspirates from 43 infants were examined to demonstrate cytological changes in bronchial epithelial cells that progressed to dysplasia. It was cytologically designated Class III. According to cytological criteria, all intubated infants had reactive hyperplastic and metaplastic epithelial changes. There were dysplastic changes in 23 out of 33 who developed BPD and 7 out of 40 who had a normal outcome. The variation between the numbers of neonates that had dysplasia in the BPD and the non-BPD group was significant (P < 0.002 by chi-square test). Conclusion: In order to monitor the development of lung injury and repair, tracheal aspirate cytology is simple, non-invasive and fast. Cytological monitoring of respiratory distress infants may be helpful in the early diagnosis and prognosis of the developing BPD. Evaluating new BPD preventive treatment schemes may also be valuable.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Tracheal Aspirate Cytology of 43 High-Risk Neonates to Predict Bronchopulmonary Dysplasia Early
    AU  - Sahar Ali Mohamed
    AU  - Hossam Eldin Mohammed
    Y1  - 2019/07/12
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajlm.20190403.13
    DO  - 10.11648/j.ajlm.20190403.13
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
    SP  - 65
    EP  - 69
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20190403.13
    AB  - The main goal of this study was to assess the cytological evaluation of tracheal aspirate, in order to predict the early diagnosis of bronchopulmonary dysplasia (BPD) in high-risk babies during mechanical ventilation. Method: Samples from 43 infants (aged < 34 weeks and weighed ≤ 1500 g) were examined cytologically; who were admitted to Pediatric Intensive Care Units and diagnosed as respiratory distress syndrome by clinical and radiological criteria. Results: Up to 150 tracheal aspirates from 43 infants were examined to demonstrate cytological changes in bronchial epithelial cells that progressed to dysplasia. It was cytologically designated Class III. According to cytological criteria, all intubated infants had reactive hyperplastic and metaplastic epithelial changes. There were dysplastic changes in 23 out of 33 who developed BPD and 7 out of 40 who had a normal outcome. The variation between the numbers of neonates that had dysplasia in the BPD and the non-BPD group was significant (P < 0.002 by chi-square test). Conclusion: In order to monitor the development of lung injury and repair, tracheal aspirate cytology is simple, non-invasive and fast. Cytological monitoring of respiratory distress infants may be helpful in the early diagnosis and prognosis of the developing BPD. Evaluating new BPD preventive treatment schemes may also be valuable.
    VL  - 4
    IS  - 3
    ER  - 

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