American Journal of Laboratory Medicine

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Olfactory Neuroblastoma Presenting as a Submandibular Mass

Received: 15 March 2019    Accepted: 22 April 2019    Published: 09 May 2019
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Abstract

Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.

DOI 10.11648/j.ajlm.20190402.12
Published in American Journal of Laboratory Medicine (Volume 4, Issue 2, March 2019)
Page(s) 35-39
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Olfactory Neuroblastoma, Metastasis, Submandibular Gland

References
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Author Information
  • Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

  • Department of Histopathology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK

  • Department of Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK

  • Department of Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK

Cite This Article
  • APA Style

    Sona Appukutty, Silvana Di Palma, Stephen Whitaker, Katie Wood. (2019). Olfactory Neuroblastoma Presenting as a Submandibular Mass. American Journal of Laboratory Medicine, 4(2), 35-39. https://doi.org/10.11648/j.ajlm.20190402.12

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    ACS Style

    Sona Appukutty; Silvana Di Palma; Stephen Whitaker; Katie Wood. Olfactory Neuroblastoma Presenting as a Submandibular Mass. Am. J. Lab. Med. 2019, 4(2), 35-39. doi: 10.11648/j.ajlm.20190402.12

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    AMA Style

    Sona Appukutty, Silvana Di Palma, Stephen Whitaker, Katie Wood. Olfactory Neuroblastoma Presenting as a Submandibular Mass. Am J Lab Med. 2019;4(2):35-39. doi: 10.11648/j.ajlm.20190402.12

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  • @article{10.11648/j.ajlm.20190402.12,
      author = {Sona Appukutty and Silvana Di Palma and Stephen Whitaker and Katie Wood},
      title = {Olfactory Neuroblastoma Presenting as a Submandibular Mass},
      journal = {American Journal of Laboratory Medicine},
      volume = {4},
      number = {2},
      pages = {35-39},
      doi = {10.11648/j.ajlm.20190402.12},
      url = {https://doi.org/10.11648/j.ajlm.20190402.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajlm.20190402.12},
      abstract = {Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Olfactory Neuroblastoma Presenting as a Submandibular Mass
    AU  - Sona Appukutty
    AU  - Silvana Di Palma
    AU  - Stephen Whitaker
    AU  - Katie Wood
    Y1  - 2019/05/09
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajlm.20190402.12
    DO  - 10.11648/j.ajlm.20190402.12
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
    SP  - 35
    EP  - 39
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20190402.12
    AB  - Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.
    VL  - 4
    IS  - 2
    ER  - 

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