Rohypnol and alcohol abuse is often reported among young people. Rohypnol is often abused voluntarily to erase memory of indulgence. It is also used in perpetuating crime such as in rape cases when the perpetrator administers certain doses of rohypnol to make the victim lose the memory of such event. Interestingly, young people often abuse alcohol and rohypnol. While the former is often used as a social drug, the latter is combined in certain instances to erase or reduce the memory of such. A number of literatures exist on the effects of alcohol on heath, brain and mind; but not a good number of investigations have considered the effects of rohypnol on hippocampal structure as well as the nature of its effects when combined with alcohol. This particular investigation is aimed at modelling rohypnol and alcohol abuse and resultant effects on hippocampal histoarchitecture and biochemicals in Wistar rats. Forty eight [n=48] adult male Wistar rats were divided into six groups, A-F. Group A served as the control Group B received the low dose of flunitrazepam; Group C received the high dose of flunitrazepam; Group D received the low dose of alcohol; Group E received the high dose of alcohol; Group F received the low dose of flunitrazepam and alcohol. Experiment lasted 21 days and animals were sacrificed by cervical dislocation. Results showed that the two substances did not produce extensive structural disruption of the hippocampus. However, specific regions of the hippocampus showed morphological aberrations, resulting in mild heterogeneity. Also, the enzyme chemistry of the hippocampus cytochrome C oxidase and G6PDH enzymes was altered.
| Published in | American Journal of Laboratory Medicine (Volume 2, Issue 6) |
| DOI | 10.11648/j.ajlm.20170206.11 |
| Page(s) | 112-118 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Memory, Rohypnol, Alcohol, Hippocampus, Date Rape, Abuse
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APA Style
Owolabi Joshua Oladele, Olatunji Sunday Yinka, Olanrewaju John Afee, Okeya Ogheneruno. (2017). Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats. American Journal of Laboratory Medicine, 2(6), 112-118. https://doi.org/10.11648/j.ajlm.20170206.11
ACS Style
Owolabi Joshua Oladele; Olatunji Sunday Yinka; Olanrewaju John Afee; Okeya Ogheneruno. Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats. Am. J. Lab. Med. 2017, 2(6), 112-118. doi: 10.11648/j.ajlm.20170206.11
AMA Style
Owolabi Joshua Oladele, Olatunji Sunday Yinka, Olanrewaju John Afee, Okeya Ogheneruno. Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats. Am J Lab Med. 2017;2(6):112-118. doi: 10.11648/j.ajlm.20170206.11
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Download@article{10.11648/j.ajlm.20170206.11,
author = {Owolabi Joshua Oladele and Olatunji Sunday Yinka and Olanrewaju John Afee and Okeya Ogheneruno},
title = {Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats},
journal = {American Journal of Laboratory Medicine},
volume = {2},
number = {6},
pages = {112-118},
doi = {10.11648/j.ajlm.20170206.11},
url = {https://doi.org/10.11648/j.ajlm.20170206.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20170206.11},
abstract = {Rohypnol and alcohol abuse is often reported among young people. Rohypnol is often abused voluntarily to erase memory of indulgence. It is also used in perpetuating crime such as in rape cases when the perpetrator administers certain doses of rohypnol to make the victim lose the memory of such event. Interestingly, young people often abuse alcohol and rohypnol. While the former is often used as a social drug, the latter is combined in certain instances to erase or reduce the memory of such. A number of literatures exist on the effects of alcohol on heath, brain and mind; but not a good number of investigations have considered the effects of rohypnol on hippocampal structure as well as the nature of its effects when combined with alcohol. This particular investigation is aimed at modelling rohypnol and alcohol abuse and resultant effects on hippocampal histoarchitecture and biochemicals in Wistar rats. Forty eight [n=48] adult male Wistar rats were divided into six groups, A-F. Group A served as the control Group B received the low dose of flunitrazepam; Group C received the high dose of flunitrazepam; Group D received the low dose of alcohol; Group E received the high dose of alcohol; Group F received the low dose of flunitrazepam and alcohol. Experiment lasted 21 days and animals were sacrificed by cervical dislocation. Results showed that the two substances did not produce extensive structural disruption of the hippocampus. However, specific regions of the hippocampus showed morphological aberrations, resulting in mild heterogeneity. Also, the enzyme chemistry of the hippocampus cytochrome C oxidase and G6PDH enzymes was altered.},
year = {2017}
}
TY - JOUR T1 - Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats AU - Owolabi Joshua Oladele AU - Olatunji Sunday Yinka AU - Olanrewaju John Afee AU - Okeya Ogheneruno Y1 - 2017/10/26 PY - 2017 N1 - https://doi.org/10.11648/j.ajlm.20170206.11 DO - 10.11648/j.ajlm.20170206.11 T2 - American Journal of Laboratory Medicine JF - American Journal of Laboratory Medicine JO - American Journal of Laboratory Medicine SP - 112 EP - 118 PB - Science Publishing Group SN - 2575-386X UR - https://doi.org/10.11648/j.ajlm.20170206.11 AB - Rohypnol and alcohol abuse is often reported among young people. Rohypnol is often abused voluntarily to erase memory of indulgence. It is also used in perpetuating crime such as in rape cases when the perpetrator administers certain doses of rohypnol to make the victim lose the memory of such event. Interestingly, young people often abuse alcohol and rohypnol. While the former is often used as a social drug, the latter is combined in certain instances to erase or reduce the memory of such. A number of literatures exist on the effects of alcohol on heath, brain and mind; but not a good number of investigations have considered the effects of rohypnol on hippocampal structure as well as the nature of its effects when combined with alcohol. This particular investigation is aimed at modelling rohypnol and alcohol abuse and resultant effects on hippocampal histoarchitecture and biochemicals in Wistar rats. Forty eight [n=48] adult male Wistar rats were divided into six groups, A-F. Group A served as the control Group B received the low dose of flunitrazepam; Group C received the high dose of flunitrazepam; Group D received the low dose of alcohol; Group E received the high dose of alcohol; Group F received the low dose of flunitrazepam and alcohol. Experiment lasted 21 days and animals were sacrificed by cervical dislocation. Results showed that the two substances did not produce extensive structural disruption of the hippocampus. However, specific regions of the hippocampus showed morphological aberrations, resulting in mild heterogeneity. Also, the enzyme chemistry of the hippocampus cytochrome C oxidase and G6PDH enzymes was altered. VL - 2 IS - 6 ER -
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