Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats

Bo-Yu Huang; Chien-Chi Liu; Zhong-Yang Jian; Ming-Cheng Lin

doi:doi:10.11648/j.ajlm.20160103.11

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Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats

Bo-Yu Huang, Chien-Chi Liu, Zhong-Yang Jian, Ming-Cheng Lin

Published in American Journal of Laboratory Medicine (Volume 1, Issue 3)

Received: 2 October 2016 Accepted: 14 October 2016 Published: 10 November 2016

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Abstract

Traditional Chinese Medicine of Antrodia camphorata has been commonly used as complementary and alternative medicines in Taiwan and Asia countries due to a variety of beneficial effects such as anti-inflammatory and anti-oxidation. Biological effects of Antrodia camphorata on oxidative stress and antioxidant enzyme activity in the brain cortex, however, have not yet fully defined so far. Experimentally, twenty male Sprague-Dawley rats were randomly divided into control and experimental subject. Control and experimental rats were intraperitoneally injected with normal saline and Antrodia camphorata for consecutive 14 days, respectively. On day 15, the brain cortex was harvested and homogenates for further biochemical analysis of lipid peroxidation and antioxidant enzyme activity. Our present data showed that Antrodia camphorata can significantly (P < 0.05) reduce the magnitude of oxidative stress as presented by a declined malondialdehyde (MDA) concentration in the present work. In addition, a remarkable (P < 0.05) enhancement of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) was found in Antrodia camphorate-treated rats as compared to control subject. In conclusion, our experimental finding demonstrates the fact that neuroprotective effects of Antrodia camphorata are correlated with reducing oxidative stress and enhancing antioxidant enzyme activity in the brain cortex of rats.

Published in	American Journal of Laboratory Medicine (Volume 1, Issue 3)
DOI	10.11648/j.ajlm.20160103.11
Page(s)	29-33
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antrodia Camphorata, Brain Cortex, Oxidative Stress, Antioxidant Enzyme Activity

References

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APA Style

Bo-Yu Huang, Chien-Chi Liu, Zhong-Yang Jian, Ming-Cheng Lin. (2016). Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats. American Journal of Laboratory Medicine, 1(3), 29-33. https://doi.org/10.11648/j.ajlm.20160103.11

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ACS Style

Bo-Yu Huang; Chien-Chi Liu; Zhong-Yang Jian; Ming-Cheng Lin. Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats. Am. J. Lab. Med. 2016, 1(3), 29-33. doi: 10.11648/j.ajlm.20160103.11

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AMA Style

Bo-Yu Huang, Chien-Chi Liu, Zhong-Yang Jian, Ming-Cheng Lin. Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats. Am J Lab Med. 2016;1(3):29-33. doi: 10.11648/j.ajlm.20160103.11

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@article{10.11648/j.ajlm.20160103.11,
  author = {Bo-Yu Huang and Chien-Chi Liu and Zhong-Yang Jian and Ming-Cheng Lin},
  title = {Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats},
  journal = {American Journal of Laboratory Medicine},
  volume = {1},
  number = {3},
  pages = {29-33},
  doi = {10.11648/j.ajlm.20160103.11},
  url = {https://doi.org/10.11648/j.ajlm.20160103.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20160103.11},
  abstract = {Traditional Chinese Medicine of Antrodia camphorata has been commonly used as complementary and alternative medicines in Taiwan and Asia countries due to a variety of beneficial effects such as anti-inflammatory and anti-oxidation. Biological effects of Antrodia camphorata on oxidative stress and antioxidant enzyme activity in the brain cortex, however, have not yet fully defined so far. Experimentally, twenty male Sprague-Dawley rats were randomly divided into control and experimental subject. Control and experimental rats were intraperitoneally injected with normal saline and Antrodia camphorata for consecutive 14 days, respectively. On day 15, the brain cortex was harvested and homogenates for further biochemical analysis of lipid peroxidation and antioxidant enzyme activity. Our present data showed that Antrodia camphorata can significantly (P < 0.05) reduce the magnitude of oxidative stress as presented by a declined malondialdehyde (MDA) concentration in the present work. In addition, a remarkable (P < 0.05) enhancement of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) was found in Antrodia camphorate-treated rats as compared to control subject. In conclusion, our experimental finding demonstrates the fact that neuroprotective effects of Antrodia camphorata are correlated with reducing oxidative stress and enhancing antioxidant enzyme activity in the brain cortex of rats.},
 year = {2016}
}

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TY  - JOUR
T1  - Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats
AU  - Bo-Yu Huang
AU  - Chien-Chi Liu
AU  - Zhong-Yang Jian
AU  - Ming-Cheng Lin
Y1  - 2016/11/10
PY  - 2016
N1  - https://doi.org/10.11648/j.ajlm.20160103.11
DO  - 10.11648/j.ajlm.20160103.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 29
EP  - 33
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20160103.11
AB  - Traditional Chinese Medicine of Antrodia camphorata has been commonly used as complementary and alternative medicines in Taiwan and Asia countries due to a variety of beneficial effects such as anti-inflammatory and anti-oxidation. Biological effects of Antrodia camphorata on oxidative stress and antioxidant enzyme activity in the brain cortex, however, have not yet fully defined so far. Experimentally, twenty male Sprague-Dawley rats were randomly divided into control and experimental subject. Control and experimental rats were intraperitoneally injected with normal saline and Antrodia camphorata for consecutive 14 days, respectively. On day 15, the brain cortex was harvested and homogenates for further biochemical analysis of lipid peroxidation and antioxidant enzyme activity. Our present data showed that Antrodia camphorata can significantly (P < 0.05) reduce the magnitude of oxidative stress as presented by a declined malondialdehyde (MDA) concentration in the present work. In addition, a remarkable (P < 0.05) enhancement of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) was found in Antrodia camphorate-treated rats as compared to control subject. In conclusion, our experimental finding demonstrates the fact that neuroprotective effects of Antrodia camphorata are correlated with reducing oxidative stress and enhancing antioxidant enzyme activity in the brain cortex of rats.
VL  - 1
IS  - 3
ER  -

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Author Information

Bo-Yu Huang

Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Chien-Chi Liu

Department of Nursing, Hung Kuang University, Taichung, Taiwan
Zhong-Yang Jian

Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
Ming-Cheng Lin

Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan

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APA Style

Bo-Yu Huang, Chien-Chi Liu, Zhong-Yang Jian, Ming-Cheng Lin. (2016). Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats. American Journal of Laboratory Medicine, 1(3), 29-33. https://doi.org/10.11648/j.ajlm.20160103.11

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ACS Style

Bo-Yu Huang; Chien-Chi Liu; Zhong-Yang Jian; Ming-Cheng Lin. Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats. Am. J. Lab. Med. 2016, 1(3), 29-33. doi: 10.11648/j.ajlm.20160103.11

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AMA Style

Bo-Yu Huang, Chien-Chi Liu, Zhong-Yang Jian, Ming-Cheng Lin. Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats. Am J Lab Med. 2016;1(3):29-33. doi: 10.11648/j.ajlm.20160103.11

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@article{10.11648/j.ajlm.20160103.11,
  author = {Bo-Yu Huang and Chien-Chi Liu and Zhong-Yang Jian and Ming-Cheng Lin},
  title = {Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats},
  journal = {American Journal of Laboratory Medicine},
  volume = {1},
  number = {3},
  pages = {29-33},
  doi = {10.11648/j.ajlm.20160103.11},
  url = {https://doi.org/10.11648/j.ajlm.20160103.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20160103.11},
  abstract = {Traditional Chinese Medicine of Antrodia camphorata has been commonly used as complementary and alternative medicines in Taiwan and Asia countries due to a variety of beneficial effects such as anti-inflammatory and anti-oxidation. Biological effects of Antrodia camphorata on oxidative stress and antioxidant enzyme activity in the brain cortex, however, have not yet fully defined so far. Experimentally, twenty male Sprague-Dawley rats were randomly divided into control and experimental subject. Control and experimental rats were intraperitoneally injected with normal saline and Antrodia camphorata for consecutive 14 days, respectively. On day 15, the brain cortex was harvested and homogenates for further biochemical analysis of lipid peroxidation and antioxidant enzyme activity. Our present data showed that Antrodia camphorata can significantly (P < 0.05) reduce the magnitude of oxidative stress as presented by a declined malondialdehyde (MDA) concentration in the present work. In addition, a remarkable (P < 0.05) enhancement of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) was found in Antrodia camphorate-treated rats as compared to control subject. In conclusion, our experimental finding demonstrates the fact that neuroprotective effects of Antrodia camphorata are correlated with reducing oxidative stress and enhancing antioxidant enzyme activity in the brain cortex of rats.},
 year = {2016}
}

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TY  - JOUR
T1  - Antrodia Camphorata Declines Oxidative Stress and Enhances Antioxidant Enzyme Activity in the Brain Cortex of Rats
AU  - Bo-Yu Huang
AU  - Chien-Chi Liu
AU  - Zhong-Yang Jian
AU  - Ming-Cheng Lin
Y1  - 2016/11/10
PY  - 2016
N1  - https://doi.org/10.11648/j.ajlm.20160103.11
DO  - 10.11648/j.ajlm.20160103.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 29
EP  - 33
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20160103.11
AB  - Traditional Chinese Medicine of Antrodia camphorata has been commonly used as complementary and alternative medicines in Taiwan and Asia countries due to a variety of beneficial effects such as anti-inflammatory and anti-oxidation. Biological effects of Antrodia camphorata on oxidative stress and antioxidant enzyme activity in the brain cortex, however, have not yet fully defined so far. Experimentally, twenty male Sprague-Dawley rats were randomly divided into control and experimental subject. Control and experimental rats were intraperitoneally injected with normal saline and Antrodia camphorata for consecutive 14 days, respectively. On day 15, the brain cortex was harvested and homogenates for further biochemical analysis of lipid peroxidation and antioxidant enzyme activity. Our present data showed that Antrodia camphorata can significantly (P < 0.05) reduce the magnitude of oxidative stress as presented by a declined malondialdehyde (MDA) concentration in the present work. In addition, a remarkable (P < 0.05) enhancement of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) was found in Antrodia camphorate-treated rats as compared to control subject. In conclusion, our experimental finding demonstrates the fact that neuroprotective effects of Antrodia camphorata are correlated with reducing oxidative stress and enhancing antioxidant enzyme activity in the brain cortex of rats.
VL  - 1
IS  - 3
ER  -

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