Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis

Feng Dan; He Shuxi

doi:doi:10.11648/j.ijovs.20180302.12

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Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis

Feng Dan, He Shuxi

Received: 29 May 2018 Accepted: 4 July 2018 Published: 27 July 2018

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Abstract

Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.

DOI	10.11648/j.ijovs.20180302.12
Published in	International Journal of Ophthalmology & Visual Science (Volume 3, Issue 2, June 2018)
Page(s)	21-26
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Corneal Collagen Cross-Linking (CXL), Ultraviolet Light A (UVA), Riboflavin, Ulcerative Disease

References

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APA Style

Feng Dan, He Shuxi. (2018). Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. International Journal of Ophthalmology & Visual Science, 3(2), 21-26. https://doi.org/10.11648/j.ijovs.20180302.12

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ACS Style

Feng Dan; He Shuxi. Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. Int. J. Ophthalmol. Vis. Sci. 2018, 3(2), 21-26. doi: 10.11648/j.ijovs.20180302.12

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AMA Style

Feng Dan, He Shuxi. Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. Int J Ophthalmol Vis Sci. 2018;3(2):21-26. doi: 10.11648/j.ijovs.20180302.12

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@article{10.11648/j.ijovs.20180302.12,
  author = {Feng Dan and He Shuxi},
  title = {Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {3},
  number = {2},
  pages = {21-26},
  doi = {10.11648/j.ijovs.20180302.12},
  url = {https://doi.org/10.11648/j.ijovs.20180302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20180302.12},
  abstract = {Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.},
 year = {2018}
}

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TY  - JOUR
T1  - Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis
AU  - Feng Dan
AU  - He Shuxi
Y1  - 2018/07/27
PY  - 2018
N1  - https://doi.org/10.11648/j.ijovs.20180302.12
DO  - 10.11648/j.ijovs.20180302.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 21
EP  - 26
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20180302.12
AB  - Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.
VL  - 3
IS  - 2
ER  -

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Author Information

Feng Dan

Department of Medical College, Hunan normal University, Changsha, China
He Shuxi

Center for Ophthalmic Optics, Hunan Provincial People's Hospital, Changsha, China

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APA Style

Feng Dan, He Shuxi. (2018). Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. International Journal of Ophthalmology & Visual Science, 3(2), 21-26. https://doi.org/10.11648/j.ijovs.20180302.12

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ACS Style

Feng Dan; He Shuxi. Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. Int. J. Ophthalmol. Vis. Sci. 2018, 3(2), 21-26. doi: 10.11648/j.ijovs.20180302.12

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AMA Style

Feng Dan, He Shuxi. Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis. Int J Ophthalmol Vis Sci. 2018;3(2):21-26. doi: 10.11648/j.ijovs.20180302.12

Copy | Download

@article{10.11648/j.ijovs.20180302.12,
  author = {Feng Dan and He Shuxi},
  title = {Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {3},
  number = {2},
  pages = {21-26},
  doi = {10.11648/j.ijovs.20180302.12},
  url = {https://doi.org/10.11648/j.ijovs.20180302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20180302.12},
  abstract = {Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis
AU  - Feng Dan
AU  - He Shuxi
Y1  - 2018/07/27
PY  - 2018
N1  - https://doi.org/10.11648/j.ijovs.20180302.12
DO  - 10.11648/j.ijovs.20180302.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 21
EP  - 26
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20180302.12
AB  - Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.
VL  - 3
IS  - 2
ER  -

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