International Journal of Ophthalmology & Visual Science

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Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes

Received: 19 August 2016    Accepted: 30 August 2016    Published: 13 September 2016
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Abstract

It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.

DOI 10.11648/j.ijovs.20160101.11
Published in International Journal of Ophthalmology & Visual Science (Volume 1, Issue 1, November 2016)
Page(s) 1-7
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

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Copyright © The Author(s), 2024. Published by Science Publishing Group

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Keywords

Electroretinogram, Iintensity-Response Function, Histamine, Retina

References
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Author Information
  • Department of Physiology, Medical University of Sofia, Sofia, Bulgaria

  • Department of Physiology, Medical University of Sofia, Sofia, Bulgaria

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    Elka Popova, Petia Kupenova. (2016). Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. International Journal of Ophthalmology & Visual Science, 1(1), 1-7. https://doi.org/10.11648/j.ijovs.20160101.11

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    Elka Popova; Petia Kupenova. Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. Int. J. Ophthalmol. Vis. Sci. 2016, 1(1), 1-7. doi: 10.11648/j.ijovs.20160101.11

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    Elka Popova, Petia Kupenova. Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes. Int J Ophthalmol Vis Sci. 2016;1(1):1-7. doi: 10.11648/j.ijovs.20160101.11

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  • @article{10.11648/j.ijovs.20160101.11,
      author = {Elka Popova and Petia Kupenova},
      title = {Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes},
      journal = {International Journal of Ophthalmology & Visual Science},
      volume = {1},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.ijovs.20160101.11},
      url = {https://doi.org/10.11648/j.ijovs.20160101.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijovs.20160101.11},
      abstract = {It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.},
     year = {2016}
    }
    

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    AU  - Elka Popova
    AU  - Petia Kupenova
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    AB  - It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.
    VL  - 1
    IS  - 1
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