Effect of Gold Nanoparticles Contrast Agent Concentration on X-Ray Diagnoses: Experimental and Computational Study
American Journal of Nano Research and Applications
Volume 2, Issue 4, July 2014, Pages: 63-69
Received: Jun. 26, 2014;
Accepted: Jul. 10, 2014;
Published: Jul. 20, 2014
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Mohamed I. Badawi, Electrical Engineering Department, Alexandria University
Moustafa M. Ahmed, Prof. of Medical Biophysics, Medical Research Institute, Alexandria University and Vice Dean Faculty of Allied Medical Science, Pharos University in Alexandria
Soheir M. I. El-kholy, Prof. & head of medical Biophysics Department Medical Research Institute, Alexandria University
Nivan M. Fikry, Prof. of Biophysics in Medical Research Institute, Alexandria University
M. S. Nasr Eldin, Assistant Lecturer in Radiology Department - Faculty of Applied Medical Sciences October 6 University
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Nanotechnology applied to biological problems represents an emerging filed with its potential to offer extremely sensitive diagnostics and targeted cancer therapies. Gold nanoparticles (GNPs) are of interest as potential in vivo diagnostic and as X-ray contrast agents, the electromagnetic coupling between three-dimensional gold nanoparticles (AuNPs) is investigated in different concentration. We report on the observation of multipeaks electric field distribution between adjacent gold nanoparticles in the gap distance of AuNPs and on its edges .In this computational and exponential study we examine image reconstruction of electric field distribution occurs due to striking of x-ray on a gold nanoparticles at different concentration, also study the relation between gap distance between neighboring AuNPs. A CST STUDIO program used to calculate the electric field distribution .Electric field images of the gold nanoparticles as contrast agent demonstrate the potential of the approach for detecting the potential of gold nanoparticles in enhancing the image quality.
X-Ray Cancer Diagnoses, Gold Nanoparticles, Imaging, Nanotechnology
To cite this article
Mohamed I. Badawi,
Moustafa M. Ahmed,
Soheir M. I. El-kholy,
Nivan M. Fikry,
M. S. Nasr Eldin,
Effect of Gold Nanoparticles Contrast Agent Concentration on X-Ray Diagnoses: Experimental and Computational Study, American Journal of Nano Research and Applications.
Vol. 2, No. 4,
2014, pp. 63-69.
Jadzinsky, P.D.; Calero, G.; Ackerson, C.J.; Bushnell, D.A.; Kornberg, R.D. Structure of a thiol monolayer-protected gold nanoparticle at 1.1 A resolution. Science 2007, 318, 430–433.
Röntgen, W.C. On a new kind of rays. Nature 1896, 53,
Paciotti GF, Myer L, Weinreich D, Goia D, Pavel N, McLaughlin RE, Tamarkin L. 2004. Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery. Drug Deliv 11:169–183.
Faraday M. 1857. Experimental relations of gold (and other metals) to light. Phil Trans R Soc London 14:145–181.
Laaksonen, K., Suomela, S., Puisto, S.R., Rostedt, N.K.J., Ala-Nissila, T., and Nieminen, R.M.,Influence of high-refractive-index oxide coating on optical properties of metal nanoparticles, JOSAB, Vol. 30, Issue 2, pp. 338-348 (2013)
14. Turkevich, J.; Stevenson, P. C.; Hiller, J. Discuss. Faraday Soc. 1951, 11,
M I . Badawi , Moustafa M. Ahmed "Gold nanoparticles as high-resolution imaging contrast agent for early cancer diagnoses: Computational study" The 14th Arab International Conference of Materials Science "Materials for Biomedical Applications December 2013.
M I . Badawi , Moustafa M. Ahmed "Gold nanoparticles as high-resolution imaging contrast agent for early cancer diagnoses: Computational study" International Journal of Chemical & Applied Biological Sciences, April 2014. 274–276.