The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours.
| DOI | 10.11648/j.ijbmr.20170506.13 |
| Published in | International Journal of Biomedical Materials Research (Volume 5, Issue 6, December 2017) |
| Page(s) | 78-83 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Acetaminophen, Anti-inflammatory, Acute Toxicity, Metal Complexes
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APA Style
John Akwu Faruna, Elaoyi David Paul, Yakubu Ali Dallatu. (2017). Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions. International Journal of Biomedical Materials Research, 5(6), 78-83. https://doi.org/10.11648/j.ijbmr.20170506.13
ACS Style
John Akwu Faruna; Elaoyi David Paul; Yakubu Ali Dallatu. Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions. Int. J. Biomed. Mater. Res. 2017, 5(6), 78-83. doi: 10.11648/j.ijbmr.20170506.13
AMA Style
John Akwu Faruna, Elaoyi David Paul, Yakubu Ali Dallatu. Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions. Int J Biomed Mater Res. 2017;5(6):78-83. doi: 10.11648/j.ijbmr.20170506.13
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Download@article{10.11648/j.ijbmr.20170506.13,
author = {John Akwu Faruna and Elaoyi David Paul and Yakubu Ali Dallatu},
title = {Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions},
journal = {International Journal of Biomedical Materials Research},
volume = {5},
number = {6},
pages = {78-83},
doi = {10.11648/j.ijbmr.20170506.13},
url = {https://doi.org/10.11648/j.ijbmr.20170506.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20170506.13},
abstract = {The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours.},
year = {2017}
}
TY - JOUR T1 - Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Acetaminophen Complexes of Copper (II) and Zinc (II) Ions AU - John Akwu Faruna AU - Elaoyi David Paul AU - Yakubu Ali Dallatu Y1 - 2017/12/27 PY - 2017 N1 - https://doi.org/10.11648/j.ijbmr.20170506.13 DO - 10.11648/j.ijbmr.20170506.13 T2 - International Journal of Biomedical Materials Research JF - International Journal of Biomedical Materials Research JO - International Journal of Biomedical Materials Research SP - 78 EP - 83 PB - Science Publishing Group SN - 2330-7579 UR - https://doi.org/10.11648/j.ijbmr.20170506.13 AB - The aim of this research was to synthesize, characterize as well as to investigate the anti-inflammatory properties of Zn (II) and Cu (II) as the central atoms using acetaminophen as the complexing agent. Cu (II) and Zn (II) Complexes were synthesized and characterized by FTIR spectroscopy, UV- Visible Spectroscopy, X-Ray Diffraction Analysis, Melting Point and Conductivity Measurements. On the basis of this study, it is proven that Acetaminophen acts as a bidentate ligand coordinated to the metal ions through phenol and carbonyl oxygen atom. The acute toxic effect was carried out by the method and the rats were found to be moderately toxic and slightly toxic. The test complexes in general showed maximum inhibition percentage at about 3 hours, after 4 hours it goes on reducing and reaches a minimum at about 5 hours. VL - 5 IS - 6 ER -
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