American Journal of Bioscience and Bioengineering

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Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains

Received: 07 October 2017    Accepted: 19 October 2017    Published: 24 November 2017
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Abstract

Xylitol is an important prebiotics, and it is widely used in the fields of medicine and food. In view of the drawbacks of chemical method, much focus has been attracted into the study of xylitol biosynthesis. In this study, microorganism, method and key enzymes in the biosynthesis of xylitol were introduced. In addition, the production of xylitol from glucose by genetically engineered strains was summarized respectively.

DOI 10.11648/j.bio.20170505.13
Published in American Journal of Bioscience and Bioengineering (Volume 5, Issue 5, October 2017)
Page(s) 109-112
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Xylitol, Biosynthesis, Glucose, Genetically Engineered Strain, Enzymes

References
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[2] Qi, X. H., Wang, X., Lin, J., Zhu, J. F., Luo, Y., Deng, W. Y., Wang, F., Sun, W. J., Meng, J. Z., 2014. Microbial and enzymatic process for xylitol production from D-glucose. Current Organic Chemistry, 18, 3131-3135.
[3] Zhang, C., Zong, H., Zhuge, B., Lu, X., Fang, H., Zhuge, J., 2015. Production of Xylitol from D-Xylose by Overexpression of Xylose Reductase in Osmotolerant Yeast Candida glycerinogenes WL2002-5. Applied Biochemistry and Biotechnology, 176, 1511-1527.
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[7] Tamburini, E., Costa, S., Marchetti, M. G., Pedrini, P., 2015. Optimized Production of Xylitol from Xylose Using a Hyper-Acidophilic Candida tropicalis. Biomolecules. 5, 1979-1989.
[8] Pratter, S. M., Eixelsberger, T., Nidetzky, B., 2015. Systematic strain construction and process development: Xylitol production by Saccharomyces cerevisiae expressing Candida tenuis xylose reductase in wild-type or mutant form. Bioresoure Technology, 198, 732-738.
[9] Qi, X., Zhang, H., Magocha, T. A., An, Y., Yun, J., Yang, M., Xue, Y., Liang, S., Sun, W., Cao, Z., 2017. Improved xylitol production by expressing a novel D-arabitol dehydrogenase from isolated Gluconobacter sp. JX-05 and co-biotransformation of whole cells. Bioresoure Technology, 235, 50-58.
[10] Onishi, H., Suzuki, T., 1969. Microbial production of xylitol from glucose. Applied Microbiology, 18, 1031-1035.
[11] Sampaio, F. C., Mantovani, H. C., Passos, F. J. V., Moraes, C. A. d., Converti, A., Passos, F. M. L., 2005. Bioconversion of d-xylose to xylitol by Debaryomyces hansenii UFV-170: Product formation versus growth. Process Biochemistry, 40, 3600-3606.
[12] Suzuki, T., Yokoyama, S., Kinoshita, Y., Yamada, H., Hatsu, M., Takamizawa, K., Kawai, K., 1999. Expression of xyrA gene encoding for D-Xylose reductase of Candida tropicalis and production of xylitol in Escherichia coli. Journal of Bioscience and Bioengineering, 87, 280-284.
[13] Suzuki, S., Sugiyama, M., Mihara, Y., Hashiguchi, K., Yokozeki, K. 2002. Novel enzymatic method for the production of xylitol from D-arabitol by Gluconobacter oxydans. Bioscience Biotechnology and Biochemistry, Vol. 66, pp. 2614-2620.
[14] Li, S., Zhang, J. L., Xu, H., Feng, X. H., 2016. Improved xylitol production from D-arabitol by enhancing the coenzyme regeneration efficiency of the pentose phosphate pathway in Gluconobacter oxydans. Journal of Agricultural and Food Chemistry, 64, 1144-1150.
[15] Cheng, H. R., Jiang, N., Shen, A., Feng, Y. J., 2005. Molecular cloning and functional expression of D-arabitol dehydrogenase gene from Gluconobacter oxydans in Escherichia coli. FEMS Microbiology Letters, 252, 35-42.
[16] Cheng, H. R., Li, Z. L., Jiang, N., Deng, Z. X., 2009. Cloning, Purification and characterization of an NAD-dependent D-arabitol dehydrogenase from Acetic Acid Bacterium, Acetobacter suboxydans. Protein Journal, 28, 263-272.
[17] Granstrom, T. B., Izumori, K., Leisola, M., 2007. A rare sugar xylitol. Part II: biotechnological production and future applications of xylitol. Applied Microbiology and Biotechnology, 74, 273-276.
[18] Povelainen, M., Miasnikov, A. N., 2006. Production of D-arabitol by a metabolic engineered strain of Bacillus subtilis. Biotechnology Journal, 1, 214-219.
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Author Information
  • College of Science and Technology, Hebei Agricultural University, Cangzhou, China

  • School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China

  • School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China

  • School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China

  • School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China

  • School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China

  • School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China

  • School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China

  • College of Science and Technology, Hebei Agricultural University, Cangzhou, China

  • College of Forestry, Hebei Agricultural University, Baoding, China

Cite This Article
  • APA Style

    Yilin Qi, Huanhuan Zhang, Junhua Yun, Miaomiao Yang, Guoyan Zhang, et al. (2017). Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains. American Journal of Bioscience and Bioengineering, 5(5), 109-112. https://doi.org/10.11648/j.bio.20170505.13

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    ACS Style

    Yilin Qi; Huanhuan Zhang; Junhua Yun; Miaomiao Yang; Guoyan Zhang, et al. Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains. Am. J. BioSci. Bioeng. 2017, 5(5), 109-112. doi: 10.11648/j.bio.20170505.13

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    AMA Style

    Yilin Qi, Huanhuan Zhang, Junhua Yun, Miaomiao Yang, Guoyan Zhang, et al. Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains. Am J BioSci Bioeng. 2017;5(5):109-112. doi: 10.11648/j.bio.20170505.13

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  • @article{10.11648/j.bio.20170505.13,
      author = {Yilin Qi and Huanhuan Zhang and Junhua Yun and Miaomiao Yang and Guoyan Zhang and Yanbo Xue and Xuexia Bai and Xianghui Qi and Yanqin Liu and Longxian Ran},
      title = {Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains},
      journal = {American Journal of Bioscience and Bioengineering},
      volume = {5},
      number = {5},
      pages = {109-112},
      doi = {10.11648/j.bio.20170505.13},
      url = {https://doi.org/10.11648/j.bio.20170505.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.bio.20170505.13},
      abstract = {Xylitol is an important prebiotics, and it is widely used in the fields of medicine and food. In view of the drawbacks of chemical method, much focus has been attracted into the study of xylitol biosynthesis. In this study, microorganism, method and key enzymes in the biosynthesis of xylitol were introduced. In addition, the production of xylitol from glucose by genetically engineered strains was summarized respectively.},
     year = {2017}
    }
    

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    T1  - Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains
    AU  - Yilin Qi
    AU  - Huanhuan Zhang
    AU  - Junhua Yun
    AU  - Miaomiao Yang
    AU  - Guoyan Zhang
    AU  - Yanbo Xue
    AU  - Xuexia Bai
    AU  - Xianghui Qi
    AU  - Yanqin Liu
    AU  - Longxian Ran
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    T2  - American Journal of Bioscience and Bioengineering
    JF  - American Journal of Bioscience and Bioengineering
    JO  - American Journal of Bioscience and Bioengineering
    SP  - 109
    EP  - 112
    PB  - Science Publishing Group
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    AB  - Xylitol is an important prebiotics, and it is widely used in the fields of medicine and food. In view of the drawbacks of chemical method, much focus has been attracted into the study of xylitol biosynthesis. In this study, microorganism, method and key enzymes in the biosynthesis of xylitol were introduced. In addition, the production of xylitol from glucose by genetically engineered strains was summarized respectively.
    VL  - 5
    IS  - 5
    ER  - 

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