Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey

Khatere Khosravian Dehkordi; Soraya khosravian Dehkordi; Rahmat Allah Fatahian Dehkordi

doi:doi:10.11648/j.avs.20150305.14

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Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey

Khatere Khosravian Dehkordi, Soraya khosravian Dehkordi, Rahmat Allah Fatahian Dehkordi

Received: 26 June 2015 Accepted: 10 August 2015 Published: 6 September 2015

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Abstract

Lead is one of the environmental pollutants that can effect on the life of living animates in several ways; it has a long half-life and is collected in the soft tissue and conduct to adverse effects in tissues. The present study was performed to investigate the histological effects caused by lead in the rat liver. The study was conducted on 20 rat, the animals were divided into 2 equal groups. The first group received distilled water and considered as a control group. The second groups were orally administered lead acetate 8.5 mg/l of body weight for 20 weeks. The rats were anesthetized, the liver were removed for histological studies. Histological changes which observed in the liver were vacuolation, fatty degeneration, congestion within central veins, hemorrhage and infiltration of inflammatory cells. In this study, harmful toxic effects observed in liver of rats.

DOI	10.11648/j.avs.20150305.14
Published in	Animal and Veterinary Sciences (Volume 3, Issue 5, September 2015)
Page(s)	141-143
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Lead, Histological Alterations, Liver

References

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[3]	Riaz, F., Khan, U. A., Ayub, M., Shaukat, S. 2011. Protective role of ginger on lead induced derangement in plasma testosterone and luteinizing hormone levels of male Sprague Dawley rats. J Ayub Med Coll Abbottabad, 23(4).
[4]	Tian, L., Lawrence, D. A. 1995. Lead inhibits nitric oxide production in vitro by murine splenic macrophages. ToxicolApplPharmacol, 132(1): 156-63.
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[6]	Meyer, P. A., Brown, M. J., Falk, H. 2008. Global approach to reducing lead exposure and poisoning. Mutat Res - Rev Mut Res, 659(1): 166-75.
[7]	Goyer, R. A., Clarkson, T. W. 1996. Toxic effects of metals. Casarett&Doull’s Toxicology The Basic Science of Poisons, Fifth Edition, Klaassen, CD [Ed] McGraw-Hill Health Professions Division, ISBN, 71054766: pp. 811-67.
[8]	Loghman-Adham, M. 1997. Renal effects of environmental and occupational lead exposure. Environmental Health Perspectives, 105(9): 923-8.
[9]	Gidlow, D. A. 2004. Lead Toxicity. Depth Review Occupational Medicine, 54: 76-81.
[10]	Plumlee, K. H. 2004. Metals and Minerals in Clinical Veterinary Toxicology, 1st Edn. Mosby, U.S.A. pp. 193-230.
[11]	Durgut, R., Koc, A., Gonenci, R., Bal, R., Celik, S., Guzel, M., et al. 2008. Effects of high dose lead toxication on liver, kidneys, heart, brain and blood in rabbits: an experimental study. Journal of Applied Biological Sciences, 2(2): 11-8.
[12]	US-EPA. 1986. Air quality criteria document for lead (Pb), Vol. 4. Washington DC: US Environmental Protection Agency. PP. 264-7.
[13]	Piasek, M., Kostial, K., Bunarević, A. 1989. The effect of lead exposure on pathohistological changes in the liver and kidney in relation to age in rats. Arhivzahigijenuradaitoksikologiju, 40(1): 15-21.
[14]	Kojima, M., Sekikawa, K., Nemoto, K., Degawa, M. 2005. Tumor necrosis factor-α-independent downregulation of hepatic cholesterol 7α-hydroxylase gene in mice treated with lead nitrate. Toxicological Sciences, 87(2): 537-42.
[15]	Calabrese, E. J., Baldwin, L. A. 1992. Lead-induced cell proliferation and organ-specific tumorigenicity. Drug Metabolism Reviews, 24(3): 409-16.
[16]	Suzuki, T., Morimura, S., Diccianni, M. B., Yamada, R., Hochi, S.-i., Hirabayashi, M., et al. 1996. Activation of glutathione transferase P gene by lead requires glutathione transferase P enhancer I. Journal of Biological Chemistry, 271(3): 1626-32.
[17]	Gajawat, S., Sancheti, G., Goyal, P. 2005. Vitamin; C against Concomitant Exposure to Heavy Metal and Radiation: A Study on Variations in Hepatic Cellular Counts. Asian Journal of Experimental Sciences, 19(2): 53-8.

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Khatere Khosravian Dehkordi, Soraya khosravian Dehkordi, Rahmat Allah Fatahian Dehkordi. (2015). Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Animal and Veterinary Sciences, 3(5), 141-143. https://doi.org/10.11648/j.avs.20150305.14

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ACS Style

Khatere Khosravian Dehkordi; Soraya khosravian Dehkordi; Rahmat Allah Fatahian Dehkordi. Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Anim. Vet. Sci. 2015, 3(5), 141-143. doi: 10.11648/j.avs.20150305.14

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AMA Style

Khatere Khosravian Dehkordi, Soraya khosravian Dehkordi, Rahmat Allah Fatahian Dehkordi. Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Anim Vet Sci. 2015;3(5):141-143. doi: 10.11648/j.avs.20150305.14

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@article{10.11648/j.avs.20150305.14,
  author = {Khatere Khosravian Dehkordi and Soraya khosravian Dehkordi and Rahmat Allah Fatahian Dehkordi},
  title = {Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey},
  journal = {Animal and Veterinary Sciences},
  volume = {3},
  number = {5},
  pages = {141-143},
  doi = {10.11648/j.avs.20150305.14},
  url = {https://doi.org/10.11648/j.avs.20150305.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20150305.14},
  abstract = {Lead is one of the environmental pollutants that can effect on the life of living animates in several ways; it has a long half-life and is collected in the soft tissue and conduct to adverse effects in tissues. The present study was performed to investigate the histological effects caused by lead in the rat liver. The study was conducted on 20 rat, the animals were divided into 2 equal groups. The first group received distilled water and considered as a control group. The second groups were orally administered lead acetate 8.5 mg/l of body weight for 20 weeks. The rats were anesthetized, the liver were removed for histological studies. Histological changes which observed in the liver were vacuolation, fatty degeneration, congestion within central veins, hemorrhage and infiltration of inflammatory cells. In this study, harmful toxic effects observed in liver of rats.},
 year = {2015}
}

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TY  - JOUR
T1  - Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey
AU  - Khatere Khosravian Dehkordi
AU  - Soraya khosravian Dehkordi
AU  - Rahmat Allah Fatahian Dehkordi
Y1  - 2015/09/06
PY  - 2015
N1  - https://doi.org/10.11648/j.avs.20150305.14
DO  - 10.11648/j.avs.20150305.14
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 141
EP  - 143
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20150305.14
AB  - Lead is one of the environmental pollutants that can effect on the life of living animates in several ways; it has a long half-life and is collected in the soft tissue and conduct to adverse effects in tissues. The present study was performed to investigate the histological effects caused by lead in the rat liver. The study was conducted on 20 rat, the animals were divided into 2 equal groups. The first group received distilled water and considered as a control group. The second groups were orally administered lead acetate 8.5 mg/l of body weight for 20 weeks. The rats were anesthetized, the liver were removed for histological studies. Histological changes which observed in the liver were vacuolation, fatty degeneration, congestion within central veins, hemorrhage and infiltration of inflammatory cells. In this study, harmful toxic effects observed in liver of rats.
VL  - 3
IS  - 5
ER  -

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Author Information

Khatere Khosravian Dehkordi

Department of Animal Physiology, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran
Soraya khosravian Dehkordi

Department of Basic Sciences, Azad University of Shahrekord, Shahrekord, Iran
Rahmat Allah Fatahian Dehkordi

Department of Basic Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran

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Plain Text BibTeX RIS

APA Style

Khatere Khosravian Dehkordi, Soraya khosravian Dehkordi, Rahmat Allah Fatahian Dehkordi. (2015). Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Animal and Veterinary Sciences, 3(5), 141-143. https://doi.org/10.11648/j.avs.20150305.14

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ACS Style

Khatere Khosravian Dehkordi; Soraya khosravian Dehkordi; Rahmat Allah Fatahian Dehkordi. Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Anim. Vet. Sci. 2015, 3(5), 141-143. doi: 10.11648/j.avs.20150305.14

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AMA Style

Khatere Khosravian Dehkordi, Soraya khosravian Dehkordi, Rahmat Allah Fatahian Dehkordi. Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Anim Vet Sci. 2015;3(5):141-143. doi: 10.11648/j.avs.20150305.14

Copy | Download

@article{10.11648/j.avs.20150305.14,
  author = {Khatere Khosravian Dehkordi and Soraya khosravian Dehkordi and Rahmat Allah Fatahian Dehkordi},
  title = {Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey},
  journal = {Animal and Veterinary Sciences},
  volume = {3},
  number = {5},
  pages = {141-143},
  doi = {10.11648/j.avs.20150305.14},
  url = {https://doi.org/10.11648/j.avs.20150305.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20150305.14},
  abstract = {Lead is one of the environmental pollutants that can effect on the life of living animates in several ways; it has a long half-life and is collected in the soft tissue and conduct to adverse effects in tissues. The present study was performed to investigate the histological effects caused by lead in the rat liver. The study was conducted on 20 rat, the animals were divided into 2 equal groups. The first group received distilled water and considered as a control group. The second groups were orally administered lead acetate 8.5 mg/l of body weight for 20 weeks. The rats were anesthetized, the liver were removed for histological studies. Histological changes which observed in the liver were vacuolation, fatty degeneration, congestion within central veins, hemorrhage and infiltration of inflammatory cells. In this study, harmful toxic effects observed in liver of rats.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey
AU  - Khatere Khosravian Dehkordi
AU  - Soraya khosravian Dehkordi
AU  - Rahmat Allah Fatahian Dehkordi
Y1  - 2015/09/06
PY  - 2015
N1  - https://doi.org/10.11648/j.avs.20150305.14
DO  - 10.11648/j.avs.20150305.14
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 141
EP  - 143
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20150305.14
AB  - Lead is one of the environmental pollutants that can effect on the life of living animates in several ways; it has a long half-life and is collected in the soft tissue and conduct to adverse effects in tissues. The present study was performed to investigate the histological effects caused by lead in the rat liver. The study was conducted on 20 rat, the animals were divided into 2 equal groups. The first group received distilled water and considered as a control group. The second groups were orally administered lead acetate 8.5 mg/l of body weight for 20 weeks. The rats were anesthetized, the liver were removed for histological studies. Histological changes which observed in the liver were vacuolation, fatty degeneration, congestion within central veins, hemorrhage and infiltration of inflammatory cells. In this study, harmful toxic effects observed in liver of rats.
VL  - 3
IS  - 5
ER  -

Copy | Download