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Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet

Received: 9 June 2015     Accepted: 29 June 2015     Published: 8 July 2015
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Abstract

L-carnitine is essential for energy production and fatty acid metabolism. This study was designed to evaluate effects of L-carnitine on liver enzymes in rats fed cholesterol rich diet. Thirty two healthy male Wistar Albino rats were divided to four groups as Control (K), Cholesterol (C), L-carnitine (L) and L-carnitine+cholesterol (LC). All rats were kept in individual cages during the experiment for 40 days. K group was fed standard rat pellets ad libitum, C group was fed standard rat pellets containing 7.5 % cholesterol powder, L group was fed standard rat pellets and water containing 75 mg/l L-carnitine and LC group was fed standard rat pellets containing 7.5% cholesterol and water containing 75 mg/l L-carnitine. At the end of the study, blood samples were taken from all animals in order to determine aspartase transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT)levels. AST, ALT, ALP, and GGT levels significantly increased in C group compared to K group (p<0.05). In LC group, AST, ALT, ALP levels significantly decreased compared with the C group (p<0.05). Although GGT level in LC group was decreased, the change was not different from C group. These results indicate that L-carnitine may prevent liver damage caused by high cholesterol diet in rats.

Published in Animal and Veterinary Sciences (Volume 3, Issue 4)
DOI 10.11648/j.avs.20150304.14
Page(s) 117-119
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

L-carnitine, Cholesterol, Liver Enzymes, Rat

References
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Cite This Article
  • APA Style

    Ercan Keskin, Deniz Uluisik, Mehmet Altin. (2015). Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet. Animal and Veterinary Sciences, 3(4), 117-119. https://doi.org/10.11648/j.avs.20150304.14

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    ACS Style

    Ercan Keskin; Deniz Uluisik; Mehmet Altin. Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet. Anim. Vet. Sci. 2015, 3(4), 117-119. doi: 10.11648/j.avs.20150304.14

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    AMA Style

    Ercan Keskin, Deniz Uluisik, Mehmet Altin. Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet. Anim Vet Sci. 2015;3(4):117-119. doi: 10.11648/j.avs.20150304.14

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  • @article{10.11648/j.avs.20150304.14,
      author = {Ercan Keskin and Deniz Uluisik and Mehmet Altin},
      title = {Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet},
      journal = {Animal and Veterinary Sciences},
      volume = {3},
      number = {4},
      pages = {117-119},
      doi = {10.11648/j.avs.20150304.14},
      url = {https://doi.org/10.11648/j.avs.20150304.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20150304.14},
      abstract = {L-carnitine is essential for energy production and fatty acid metabolism. This study was designed to evaluate effects of L-carnitine on liver enzymes in rats fed cholesterol rich diet. Thirty two healthy male Wistar Albino rats were divided to four groups as Control (K), Cholesterol (C), L-carnitine (L) and L-carnitine+cholesterol (LC). All rats were kept in individual cages during the experiment for 40 days. K group was fed standard rat pellets ad libitum, C group was fed standard rat pellets containing 7.5 % cholesterol powder, L group was fed standard rat pellets and water containing 75 mg/l L-carnitine and LC group was fed standard rat pellets containing 7.5% cholesterol and water containing 75 mg/l L-carnitine. At the end of the study, blood samples were taken from all animals in order to determine aspartase transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT)levels. AST, ALT, ALP, and GGT levels significantly increased in C group compared to K group (p<0.05). In LC group, AST, ALT, ALP levels significantly decreased compared with the C group (p<0.05). Although GGT level in LC group was decreased, the change was not different from C group. These results indicate that L-carnitine may prevent liver damage caused by high cholesterol diet in rats.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Effects of L-Carnitine on Liver Enzymes in Rats Fed Cholesterol Rich Diet
    AU  - Ercan Keskin
    AU  - Deniz Uluisik
    AU  - Mehmet Altin
    Y1  - 2015/07/08
    PY  - 2015
    N1  - https://doi.org/10.11648/j.avs.20150304.14
    DO  - 10.11648/j.avs.20150304.14
    T2  - Animal and Veterinary Sciences
    JF  - Animal and Veterinary Sciences
    JO  - Animal and Veterinary Sciences
    SP  - 117
    EP  - 119
    PB  - Science Publishing Group
    SN  - 2328-5850
    UR  - https://doi.org/10.11648/j.avs.20150304.14
    AB  - L-carnitine is essential for energy production and fatty acid metabolism. This study was designed to evaluate effects of L-carnitine on liver enzymes in rats fed cholesterol rich diet. Thirty two healthy male Wistar Albino rats were divided to four groups as Control (K), Cholesterol (C), L-carnitine (L) and L-carnitine+cholesterol (LC). All rats were kept in individual cages during the experiment for 40 days. K group was fed standard rat pellets ad libitum, C group was fed standard rat pellets containing 7.5 % cholesterol powder, L group was fed standard rat pellets and water containing 75 mg/l L-carnitine and LC group was fed standard rat pellets containing 7.5% cholesterol and water containing 75 mg/l L-carnitine. At the end of the study, blood samples were taken from all animals in order to determine aspartase transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT)levels. AST, ALT, ALP, and GGT levels significantly increased in C group compared to K group (p<0.05). In LC group, AST, ALT, ALP levels significantly decreased compared with the C group (p<0.05). Although GGT level in LC group was decreased, the change was not different from C group. These results indicate that L-carnitine may prevent liver damage caused by high cholesterol diet in rats.
    VL  - 3
    IS  - 4
    ER  - 

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Author Information
  • Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey

  • Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey

  • School of Physical Education and Sports, University of Selcuk, Konya, Turkey

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