Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet

Ercan Keskin; Deniz Uluisik; Mehmet Altin

doi:doi:10.11648/j.avs.20150304.13

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Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet

Ercan Keskin, Deniz Uluisik, Mehmet Altin

Published in Animal and Veterinary Sciences (Volume 3, Issue 4)

Received: 9 June 2015 Accepted: 26 June 2015 Published: 7 July 2015

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Abstract

This study was conducted to assess the effects of L-carnitine on antioxidant enzymes in rats fed cholesterol rich diet. A total of 32 healthy male Wistar Albino rats were allocated to four groups. Animals of the first group were fed standard rat pellets, animals of the second group were fed standard rat pellets that contained 7.5 % cholesterol powder, animals of the third group were fed standard rat pellets and water contained 75 mg/l L-carnitine while those of the forth group were fed standard rat pellets that contained 7.5 % cholesterol and water that contained 75 mg/l L-carnitine for 40 days. On the 40 th day of the study, blood samples were taken from all animals and thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels were determined. The results showed that feeding with high cholesterol diet resulted significantly increase in TBARS level and decreases in GSH, SOD, GPx levels when compared to control group (p<0.05). L-carnitine addition to the high cholesterol diet significantly decreased in TBARS level and increased in GSH, SOD levels compared to cholesterol group (p<0.05). In conclusion, our results showed L-carnitine may be useful an antioxidant in hypercholesterolemic condition.

Published in	Animal and Veterinary Sciences (Volume 3, Issue 4)
DOI	10.11648/j.avs.20150304.13
Page(s)	113-116
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

L-carnitine, Cholesterol, Antioxidants, Lipid Peroxidation, Rat

References

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APA Style

Ercan Keskin, Deniz Uluisik, Mehmet Altin. (2015). Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet. Animal and Veterinary Sciences, 3(4), 113-116. https://doi.org/10.11648/j.avs.20150304.13

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ACS Style

Ercan Keskin; Deniz Uluisik; Mehmet Altin. Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet. Anim. Vet. Sci. 2015, 3(4), 113-116. doi: 10.11648/j.avs.20150304.13

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AMA Style

Ercan Keskin, Deniz Uluisik, Mehmet Altin. Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet. Anim Vet Sci. 2015;3(4):113-116. doi: 10.11648/j.avs.20150304.13

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@article{10.11648/j.avs.20150304.13,
  author = {Ercan Keskin and Deniz Uluisik and Mehmet Altin},
  title = {Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet},
  journal = {Animal and Veterinary Sciences},
  volume = {3},
  number = {4},
  pages = {113-116},
  doi = {10.11648/j.avs.20150304.13},
  url = {https://doi.org/10.11648/j.avs.20150304.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20150304.13},
  abstract = {This study was conducted to assess the effects of L-carnitine on antioxidant enzymes in rats fed cholesterol rich diet. A total of 32 healthy male Wistar Albino rats were allocated to four groups. Animals of the first group were fed standard rat pellets, animals of the second group were fed standard rat pellets that contained 7.5 % cholesterol powder, animals of the third group were fed standard rat pellets and water contained 75 mg/l L-carnitine while those of the forth group were fed standard rat pellets that contained 7.5 % cholesterol and water that contained 75 mg/l L-carnitine for 40 days. On the 40 th day of the study, blood samples were taken from all animals and thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels were determined. The results showed that feeding with high cholesterol diet resulted significantly increase in TBARS level and decreases in GSH, SOD, GPx levels when compared to control group (p<0.05). L-carnitine addition to the high cholesterol diet significantly decreased in TBARS level and increased in GSH, SOD levels compared to cholesterol group (p<0.05). In conclusion, our results showed L-carnitine may be useful an antioxidant in hypercholesterolemic condition.},
 year = {2015}
}

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TY  - JOUR
T1  - Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet
AU  - Ercan Keskin
AU  - Deniz Uluisik
AU  - Mehmet Altin
Y1  - 2015/07/07
PY  - 2015
N1  - https://doi.org/10.11648/j.avs.20150304.13
DO  - 10.11648/j.avs.20150304.13
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 113
EP  - 116
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20150304.13
AB  - This study was conducted to assess the effects of L-carnitine on antioxidant enzymes in rats fed cholesterol rich diet. A total of 32 healthy male Wistar Albino rats were allocated to four groups. Animals of the first group were fed standard rat pellets, animals of the second group were fed standard rat pellets that contained 7.5 % cholesterol powder, animals of the third group were fed standard rat pellets and water contained 75 mg/l L-carnitine while those of the forth group were fed standard rat pellets that contained 7.5 % cholesterol and water that contained 75 mg/l L-carnitine for 40 days. On the 40 th day of the study, blood samples were taken from all animals and thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels were determined. The results showed that feeding with high cholesterol diet resulted significantly increase in TBARS level and decreases in GSH, SOD, GPx levels when compared to control group (p<0.05). L-carnitine addition to the high cholesterol diet significantly decreased in TBARS level and increased in GSH, SOD levels compared to cholesterol group (p<0.05). In conclusion, our results showed L-carnitine may be useful an antioxidant in hypercholesterolemic condition.
VL  - 3
IS  - 4
ER  -

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Author Information

Ercan Keskin

Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey
Deniz Uluisik

Department of Physiology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey
Mehmet Altin

School of Physical Education and Sports, University of Selcuk, Konya, Turkey

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APA Style

Ercan Keskin, Deniz Uluisik, Mehmet Altin. (2015). Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet. Animal and Veterinary Sciences, 3(4), 113-116. https://doi.org/10.11648/j.avs.20150304.13

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ACS Style

Ercan Keskin; Deniz Uluisik; Mehmet Altin. Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet. Anim. Vet. Sci. 2015, 3(4), 113-116. doi: 10.11648/j.avs.20150304.13

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AMA Style

Ercan Keskin, Deniz Uluisik, Mehmet Altin. Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet. Anim Vet Sci. 2015;3(4):113-116. doi: 10.11648/j.avs.20150304.13

Copy | Download

@article{10.11648/j.avs.20150304.13,
  author = {Ercan Keskin and Deniz Uluisik and Mehmet Altin},
  title = {Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet},
  journal = {Animal and Veterinary Sciences},
  volume = {3},
  number = {4},
  pages = {113-116},
  doi = {10.11648/j.avs.20150304.13},
  url = {https://doi.org/10.11648/j.avs.20150304.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20150304.13},
  abstract = {This study was conducted to assess the effects of L-carnitine on antioxidant enzymes in rats fed cholesterol rich diet. A total of 32 healthy male Wistar Albino rats were allocated to four groups. Animals of the first group were fed standard rat pellets, animals of the second group were fed standard rat pellets that contained 7.5 % cholesterol powder, animals of the third group were fed standard rat pellets and water contained 75 mg/l L-carnitine while those of the forth group were fed standard rat pellets that contained 7.5 % cholesterol and water that contained 75 mg/l L-carnitine for 40 days. On the 40 th day of the study, blood samples were taken from all animals and thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels were determined. The results showed that feeding with high cholesterol diet resulted significantly increase in TBARS level and decreases in GSH, SOD, GPx levels when compared to control group (p<0.05). L-carnitine addition to the high cholesterol diet significantly decreased in TBARS level and increased in GSH, SOD levels compared to cholesterol group (p<0.05). In conclusion, our results showed L-carnitine may be useful an antioxidant in hypercholesterolemic condition.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Antioxidant Effect of L-carnitine in Rats Fed Cholesterol Rich Diet
AU  - Ercan Keskin
AU  - Deniz Uluisik
AU  - Mehmet Altin
Y1  - 2015/07/07
PY  - 2015
N1  - https://doi.org/10.11648/j.avs.20150304.13
DO  - 10.11648/j.avs.20150304.13
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 113
EP  - 116
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20150304.13
AB  - This study was conducted to assess the effects of L-carnitine on antioxidant enzymes in rats fed cholesterol rich diet. A total of 32 healthy male Wistar Albino rats were allocated to four groups. Animals of the first group were fed standard rat pellets, animals of the second group were fed standard rat pellets that contained 7.5 % cholesterol powder, animals of the third group were fed standard rat pellets and water contained 75 mg/l L-carnitine while those of the forth group were fed standard rat pellets that contained 7.5 % cholesterol and water that contained 75 mg/l L-carnitine for 40 days. On the 40 th day of the study, blood samples were taken from all animals and thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels were determined. The results showed that feeding with high cholesterol diet resulted significantly increase in TBARS level and decreases in GSH, SOD, GPx levels when compared to control group (p<0.05). L-carnitine addition to the high cholesterol diet significantly decreased in TBARS level and increased in GSH, SOD levels compared to cholesterol group (p<0.05). In conclusion, our results showed L-carnitine may be useful an antioxidant in hypercholesterolemic condition.
VL  - 3
IS  - 4
ER  -

Copy | Download