International Journal of Science, Technology and Society

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Evaluation of a Poly (Acrylic) Acid Polymer as a Sustained Release Matrix for Ciprofloxacin Hydrochloride

Received: 26 May 2014    Accepted: 20 June 2014    Published: 30 July 2014
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Abstract

An evaluation of the sustained release (SR) properties of a polyacrylic acid polymer, Carbopol 971(CP 971) as matrix in the formulation of ciprofloxacin hydrochloride (CH) tablets was carried out. The CP 971 in concentrations of up to 40 % w/w were wet granulated using ethanol 95% v/v and the dried granules were evaluated for packing, densification and flow properties. The tablets were evaluated for hardness, friability, uniformity of weight and content of active ingredient. The formulations dissolution profiles were tested in 0.1 N Hydrochloric acid (0.1 N HCl, pH 1.3), simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.2) without enzymes. Results obtained showed significant retardation (p < 0.05) of ciprofloxacin release as the polymer concentration increased. Drug release was significantly different in the three media used with the release rate being faster in SGF than 0.1 N HCl and SIF. This can be attributed to the high solubility of the drug in acidic media. More than 50% of drug content was released within 4 h. Ciprofloxacin tablets containing 20 % w/w was adjudged the best formulation and drug release from the formulation was diffusion controlled (Fickian).

DOI 10.11648/j.ijsts.20140204.15
Published in International Journal of Science, Technology and Society (Volume 2, Issue 4, July 2014)
Page(s) 85-90
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Poly (Acrylic) Acid, Ciprofloxacin Hydrochloride, Micromeritics, Densification, Sustained Release

References
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    Nwachukwu, Nkemakolam, Emeje, O. Martin, Ofoefule, et al. (2014). Evaluation of a Poly (Acrylic) Acid Polymer as a Sustained Release Matrix for Ciprofloxacin Hydrochloride. International Journal of Science, Technology and Society, 2(4), 85-90. https://doi.org/10.11648/j.ijsts.20140204.15

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    ACS Style

    Nwachukwu; Nkemakolam; Emeje; O. Martin; Ofoefule, et al. Evaluation of a Poly (Acrylic) Acid Polymer as a Sustained Release Matrix for Ciprofloxacin Hydrochloride. Int. J. Sci. Technol. Soc. 2014, 2(4), 85-90. doi: 10.11648/j.ijsts.20140204.15

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    AMA Style

    Nwachukwu, Nkemakolam, Emeje, O. Martin, Ofoefule, et al. Evaluation of a Poly (Acrylic) Acid Polymer as a Sustained Release Matrix for Ciprofloxacin Hydrochloride. Int J Sci Technol Soc. 2014;2(4):85-90. doi: 10.11648/j.ijsts.20140204.15

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  • @article{10.11648/j.ijsts.20140204.15,
      author = {Nwachukwu and Nkemakolam and Emeje and O. Martin and Ofoefule and I. Sabinus},
      title = {Evaluation of a Poly (Acrylic) Acid Polymer as a Sustained Release Matrix for Ciprofloxacin Hydrochloride},
      journal = {International Journal of Science, Technology and Society},
      volume = {2},
      number = {4},
      pages = {85-90},
      doi = {10.11648/j.ijsts.20140204.15},
      url = {https://doi.org/10.11648/j.ijsts.20140204.15},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijsts.20140204.15},
      abstract = {An evaluation of the sustained release (SR) properties of a polyacrylic acid polymer, Carbopol 971(CP 971) as matrix in the formulation of ciprofloxacin hydrochloride (CH) tablets was carried out. The CP 971 in concentrations of up to 40 % w/w were wet granulated using ethanol 95% v/v and the dried granules were evaluated for packing, densification and flow properties. The tablets were evaluated for hardness, friability, uniformity of weight and content of active ingredient. The formulations dissolution profiles were tested in 0.1 N Hydrochloric acid (0.1 N HCl, pH 1.3), simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.2) without enzymes. Results obtained showed significant retardation (p < 0.05) of ciprofloxacin release as the polymer concentration increased. Drug release was significantly different in the three media used with the release rate being faster in SGF than 0.1 N HCl and SIF. This can be attributed to the high solubility of the drug in acidic media. More than 50% of drug content was released within 4 h. Ciprofloxacin tablets containing 20 % w/w was adjudged the best formulation and drug release from the formulation was diffusion controlled (Fickian).},
     year = {2014}
    }
    

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    T1  - Evaluation of a Poly (Acrylic) Acid Polymer as a Sustained Release Matrix for Ciprofloxacin Hydrochloride
    AU  - Nwachukwu
    AU  - Nkemakolam
    AU  - Emeje
    AU  - O. Martin
    AU  - Ofoefule
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    JF  - International Journal of Science, Technology and Society
    JO  - International Journal of Science, Technology and Society
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    PB  - Science Publishing Group
    SN  - 2330-7420
    UR  - https://doi.org/10.11648/j.ijsts.20140204.15
    AB  - An evaluation of the sustained release (SR) properties of a polyacrylic acid polymer, Carbopol 971(CP 971) as matrix in the formulation of ciprofloxacin hydrochloride (CH) tablets was carried out. The CP 971 in concentrations of up to 40 % w/w were wet granulated using ethanol 95% v/v and the dried granules were evaluated for packing, densification and flow properties. The tablets were evaluated for hardness, friability, uniformity of weight and content of active ingredient. The formulations dissolution profiles were tested in 0.1 N Hydrochloric acid (0.1 N HCl, pH 1.3), simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.2) without enzymes. Results obtained showed significant retardation (p < 0.05) of ciprofloxacin release as the polymer concentration increased. Drug release was significantly different in the three media used with the release rate being faster in SGF than 0.1 N HCl and SIF. This can be attributed to the high solubility of the drug in acidic media. More than 50% of drug content was released within 4 h. Ciprofloxacin tablets containing 20 % w/w was adjudged the best formulation and drug release from the formulation was diffusion controlled (Fickian).
    VL  - 2
    IS  - 4
    ER  - 

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