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Evaluation of a Poly (Acrylic) Acid Polymer as a Sustained Release Matrix for Ciprofloxacin Hydrochloride
International Journal of Science, Technology and Society
Volume 2, Issue 4, July 2014, Pages: 85-90
Received: May 26, 2014; Accepted: Jun. 20, 2014; Published: Jul. 30, 2014
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Authors
Nwachukwu, Nkemakolam, Department of Pharmaceutics & Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, Nigeria
Emeje, O. Martin, Department of Pharmaceutical Technology, National Institute for Pharmaceutical Research & Development, Idu, Abuja, Nigeria
Ofoefule, I. Sabinus, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Enugu State, Nigeria
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Abstract
An evaluation of the sustained release (SR) properties of a polyacrylic acid polymer, Carbopol 971(CP 971) as matrix in the formulation of ciprofloxacin hydrochloride (CH) tablets was carried out. The CP 971 in concentrations of up to 40 % w/w were wet granulated using ethanol 95% v/v and the dried granules were evaluated for packing, densification and flow properties. The tablets were evaluated for hardness, friability, uniformity of weight and content of active ingredient. The formulations dissolution profiles were tested in 0.1 N Hydrochloric acid (0.1 N HCl, pH 1.3), simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.2) without enzymes. Results obtained showed significant retardation (p < 0.05) of ciprofloxacin release as the polymer concentration increased. Drug release was significantly different in the three media used with the release rate being faster in SGF than 0.1 N HCl and SIF. This can be attributed to the high solubility of the drug in acidic media. More than 50% of drug content was released within 4 h. Ciprofloxacin tablets containing 20 % w/w was adjudged the best formulation and drug release from the formulation was diffusion controlled (Fickian).
Keywords
Poly (Acrylic) Acid, Ciprofloxacin Hydrochloride, Micromeritics, Densification, Sustained Release
To cite this article
Nwachukwu, Nkemakolam, Emeje, O. Martin, Ofoefule, I. Sabinus, Evaluation of a Poly (Acrylic) Acid Polymer as a Sustained Release Matrix for Ciprofloxacin Hydrochloride, International Journal of Science, Technology and Society. Vol. 2, No. 4, 2014, pp. 85-90. doi: 10.11648/j.ijsts.20140204.15
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