A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women
Volume 2, Issue 6, December 2014, Pages: 150-154
Received: Nov. 6, 2014;
Accepted: Nov. 17, 2014;
Published: Nov. 24, 2014
Views 3270 Downloads 241
Yakubu Emmanuel Nyam, Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria
Ajen Stephen Anzaku, Department of Obstetrics and Gynaecology, College of Health Sciences, Bingham University, Karu, Jos Campus, Jos, Nigeria
Madziga Isa Gamece, Nigeria National Petroleum Corporation, Kaduna, Nigeria
Daru Patrick Haruna, Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria
Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction. Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.
Yakubu Emmanuel Nyam,
Ajen Stephen Anzaku,
Madziga Isa Gamece,
Daru Patrick Haruna,
A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women, Science Research.
Vol. 2, No. 6,
2014, pp. 150-154.
Dutta DC. Hypertensive disorders in Pregnancy. In: Hiralal K(ed) Textbook of Obstetrics.7th edition new central book agency Kolkata, India. 2011; 17:219-20.
Jason JS, Waugh, Maria CS. Hypertensive disorder. In: Edmonds DK(ed) Dewhurst’s Textbook of Obstetrics and gynaecology, 8th edition. Wiley- Blackwell Publishing 2007; 101-2.
Abudu O.O, Afolabi B.B. Pregnancy induced hypertension, Pre-eclampsia and Chronic hypertension. In: Akin Agboola (Ed), Textbook of Obstetrics and Gynaecology for Medical Students. 2nd edition; Heinemann Educational Books. 2006:350-51.
Vanderjagt DJ, El-Nafaty AU, Melah GS et.al High density lipoprotein and homocysteine levels correlate inversely in preeclamptics women in Northern Nigeria. Acta Obstet Gynaecol Scand J 2004; 83: 536-42.
NAF Islam, MAR Chodwury, GM Kibria et.al Study of serum lipid profile in pre-eclampsia and Eclampsia. Faridpur Med coll J 2010;5:56-9.
Siddiqui IA. Maternal seum lipids in women with Preeclampsia. Ann Med Health Sci Res 2014;4:638-41.
Young BC, Levine RJ, Karumanchi SA. Pathogenesis of Preeclampsia. Annu Rev Pathol 2010,5:173-92.
Enquobahrie DA, Williams MA, Buttler CL, et.al Maternal plasma lipid concentration in early pregnancy and risk of preeclampsia. Am J Hypertens 2008; 17: 74-81.
Belo L, Caslake M, Gaffney D et.al Changes in LDL size and HDL concentration in normal and preeclamptics pregnancies. Atherosclerosis 2002; 162:425-32.
Brown MA, Lindheimer MD, de Sweit M. The classification and diagnosis of the hypertensive disorder of pregnancy. Statement from the international society for the study of hypertension in pregnancy (ISSHP) Hypertens Pregnancy 2001; 20:9-14.
Zinat B, Iffat A, Shah ABS. Association between lipid profile and Preeclampsia. Ibrahim card Med J 2011; 1:41-44.
Hubel CA, Roberts JM. Hyperuricaemia and xanthine oxidase in preeclampsia revisited Am J Obstet Gynaecol 1996; 174:288-91.
Sima AV, Stancu CS, Simionescu M, Vascular endothelium in atherosclerosis. Cell Tissue Res 2009; 335:191-203.
Lima VJ, Andrade CR et.al Serum Lipid levels in Pregnancies complicated by Preeclampsia. Sao Paulo Med J 2011; 129:73-76.
Hiralal K. Aetiopathogenesis of Pre-eclampsia In: Milind RS (Ed), Hypertensive disorders in Pregnancy. 1st Edition. Jaypee Brothers Medical Publishers. 2007; 5:39-46.
Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of Low-density lipoprotein cholesterol in plasma, without use of the ultracentrifuge. Clin Chem 1972; 18:499-502.
Abubakar A. Mabrouk M. Girei AB et.al Lipid profiles and Platelet counts of pre-eclamptic women in selected rural areas of Nigeria. Web Med Central Physiology.2011:2(8) WMCOO2121.
Ray JG, Diamond P, Singh G, Bell CM. Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG 2006; 113:379-86.
Kalar MU, Kalar N, Mansoor F, Malik AR, Lessley T, Kreimer S et al. Preeclampsia and lipid levels – a case control study. International Journal of Collaborative research in internal Medicine and Public Health 2012; 4: 1738 – 45.
Ziaei S, Bonab KM, Kazemnejad A. Serum lipid levels at 28-32 weeks gestation and hypertensive disorders. Hypertens Pregnancy 2006; 25(1):3-10.
Musa AH, Mairiga AG, Jimeta AA, Daja A. Lipid profile pattern of Preeclamptic and Eclamptic patients attending University of Maiduguri Teaching Hospital. Gynaecol Obstet (Sunnyvale) 2014; 4:217 - 201
Musleh U.K, Nabila K, Farah M. Preeclampsia and lipid levels- a case control study. International Journal of Collaborative research on internal medicine and public health. 2012; 4:1738-44.
Chanvitya P, Boonsri K. Comparative study of serum lipid concentrations in preeclampsia and Normal Pregnancy. J Med Assoc Thai 2008; 91:957-61.
Baksu B, Baksu A, Davas I. Lipoprotein levels in women with preeclampsia and in normotensive pregnant women. J obstet Gynaecol Res 2005; 31:277-82.