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A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women
Science Research
Volume 2, Issue 6, December 2014, Pages: 150-154
Received: Nov. 6, 2014; Accepted: Nov. 17, 2014; Published: Nov. 24, 2014
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Yakubu Emmanuel Nyam, Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria
Ajen Stephen Anzaku, Department of Obstetrics and Gynaecology, College of Health Sciences, Bingham University, Karu, Jos Campus, Jos, Nigeria
Madziga Isa Gamece, Nigeria National Petroleum Corporation, Kaduna, Nigeria
Daru Patrick Haruna, Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria
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Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction. Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.
Pre-Eclampsia, Serum Lipids, Total Cholesterol, Triglycerides, High Density Lipoprotein, Low Density Lipoprotein
To cite this article
Yakubu Emmanuel Nyam, Ajen Stephen Anzaku, Madziga Isa Gamece, Daru Patrick Haruna, A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women, Science Research. Vol. 2, No. 6, 2014, pp. 150-154. doi: 10.11648/
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