International Journal of Psychological and Brain Sciences

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C-Reactive Protein and Aggression in Patients with Schizophrenia

Received: 24 April 2019    Accepted: 24 May 2019    Published: 10 June 2019
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Abstract

Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP < 5 mg/L; n = 102). The following indicators of aggression were compared: PANSS excitement component (PANSS-EC), restraints, injectable treatment and suicidal behavior during hospitalization. Univariate comparisons between elevated and normal CRP levels were performed and multivariate analysis was conducted to control for relevant covariates. Inpatients with elevated C-reactive protein displayed increased aggressive behavior compared to patients with normal CRP levels (<5 mg/L). This was manifested by increased PANSS-EC score (p=0,0001), higher rates of restraint during hospitalization (p=0,0001), higher use of injectable treatment (0,0001) and existence of suicidal behavior (p=0,001). Multivariate analysis revealed that Lymphocyte count, total PANSS score, PANSS excitement score were independently associated with a CRP> 5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.

DOI 10.11648/j.ijpbs.20190402.11
Published in International Journal of Psychological and Brain Sciences (Volume 4, Issue 2, April 2019)
Page(s) 7-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Schizophrenia, Inflammation, Aggression, CRP

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Author Information
  • Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco

  • Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco

  • Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco

  • Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco

  • Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco

  • Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco

  • Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco

  • Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco

  • Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco

Cite This Article
  • APA Style

    Kachouchi Aymen, Zemrani Yassin, Ahroui Yassine, Salim Said, Berghalout Mohammed, et al. (2019). C-Reactive Protein and Aggression in Patients with Schizophrenia. International Journal of Psychological and Brain Sciences, 4(2), 7-12. https://doi.org/10.11648/j.ijpbs.20190402.11

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    ACS Style

    Kachouchi Aymen; Zemrani Yassin; Ahroui Yassine; Salim Said; Berghalout Mohammed, et al. C-Reactive Protein and Aggression in Patients with Schizophrenia. Int. J. Psychol. Brain Sci. 2019, 4(2), 7-12. doi: 10.11648/j.ijpbs.20190402.11

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    AMA Style

    Kachouchi Aymen, Zemrani Yassin, Ahroui Yassine, Salim Said, Berghalout Mohammed, et al. C-Reactive Protein and Aggression in Patients with Schizophrenia. Int J Psychol Brain Sci. 2019;4(2):7-12. doi: 10.11648/j.ijpbs.20190402.11

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  • @article{10.11648/j.ijpbs.20190402.11,
      author = {Kachouchi Aymen and Zemrani Yassin and Ahroui Yassine and Salim Said and Berghalout Mohammed and Adali Imane and Manoudi Fatiha and Chabaa Laila and Asri Fatima},
      title = {C-Reactive Protein and Aggression in Patients with Schizophrenia},
      journal = {International Journal of Psychological and Brain Sciences},
      volume = {4},
      number = {2},
      pages = {7-12},
      doi = {10.11648/j.ijpbs.20190402.11},
      url = {https://doi.org/10.11648/j.ijpbs.20190402.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijpbs.20190402.11},
      abstract = {Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP  5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.},
     year = {2019}
    }
    

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    AU  - Kachouchi Aymen
    AU  - Zemrani Yassin
    AU  - Ahroui Yassine
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    AB  - Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP  5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.
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