Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review

Rohit Raghavan; Sumitra S.; Nadeem Abdul Rahman; Justin Baby

doi:doi:10.11648/j.sjcm.s.2016050401.12

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Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review

Rohit Raghavan, Sumitra S., Nadeem Abdul Rahman, Justin Baby

Published in Science Journal of Clinical Medicine (Volume 5, Issue 4-1)

Received: 23 December 2015 Accepted: 23 February 2016 Published: 16 April 2016

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Abstract

Of all the birth defects, Cleft palate is among the most common and affects about one in 1,500 births resulting in medical, physical, developmental, social and emotional problems in affected children in addition to the high health care costs. Current treatment is based on surgical closure of the cleft followed by orthodontic dental care, speech therapy, bone grafting, and requires multiple surgeries spanning over 18 years. Thus, there is a pressing need to develop more effective methods of treatment to provide young patients with a safer option that will result in a complete closure of the palatal cleft shortly after birth. In this review, the application of the field of tissue engineering, involving the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) seeded on currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. This article presents the concise technique to generate new bone in cleft deformities, using stem cells. It also throws light on the work done by various researchers to regenerate bone in large defects.

Published in	Science Journal of Clinical Medicine (Volume 5, Issue 4-1) This article belongs to the Special Issue Clinical Conspectus on Cleft Deformities
DOI	10.11648/j.sjcm.s.2016050401.12
Page(s)	7-13
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Bone Tissue Engineering, Cleft, Stem Cells, Growth Factors, Scaffolds

References

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APA Style

Rohit Raghavan, Sumitra S., Nadeem Abdul Rahman, Justin Baby. (2016). Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Science Journal of Clinical Medicine, 5(4-1), 7-13. https://doi.org/10.11648/j.sjcm.s.2016050401.12

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ACS Style

Rohit Raghavan; Sumitra S.; Nadeem Abdul Rahman; Justin Baby. Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Sci. J. Clin. Med. 2016, 5(4-1), 7-13. doi: 10.11648/j.sjcm.s.2016050401.12

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AMA Style

Rohit Raghavan, Sumitra S., Nadeem Abdul Rahman, Justin Baby. Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Sci J Clin Med. 2016;5(4-1):7-13. doi: 10.11648/j.sjcm.s.2016050401.12

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@article{10.11648/j.sjcm.s.2016050401.12,
  author = {Rohit Raghavan and Sumitra S. and Nadeem Abdul Rahman and Justin Baby},
  title = {Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review},
  journal = {Science Journal of Clinical Medicine},
  volume = {5},
  number = {4-1},
  pages = {7-13},
  doi = {10.11648/j.sjcm.s.2016050401.12},
  url = {https://doi.org/10.11648/j.sjcm.s.2016050401.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.s.2016050401.12},
  abstract = {Of all the birth defects, Cleft palate is among the most common and affects about one in 1,500 births resulting in medical, physical, developmental, social and emotional problems in affected children in addition to the high health care costs. Current treatment is based on surgical closure of the cleft followed by orthodontic dental care, speech therapy, bone grafting, and requires multiple surgeries spanning over 18 years. Thus, there is a pressing need to develop more effective methods of treatment to provide young patients with a safer option that will result in a complete closure of the palatal cleft shortly after birth. In this review, the application of the field of tissue engineering, involving the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) seeded on currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. This article presents the concise technique to generate new bone in cleft deformities, using stem cells. It also throws light on the work done by various researchers to regenerate bone in large defects.},
 year = {2016}
}

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TY  - JOUR
T1  - Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review
AU  - Rohit Raghavan
AU  - Sumitra S.
AU  - Nadeem Abdul Rahman
AU  - Justin Baby
Y1  - 2016/04/16
PY  - 2016
N1  - https://doi.org/10.11648/j.sjcm.s.2016050401.12
DO  - 10.11648/j.sjcm.s.2016050401.12
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 7
EP  - 13
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.s.2016050401.12
AB  - Of all the birth defects, Cleft palate is among the most common and affects about one in 1,500 births resulting in medical, physical, developmental, social and emotional problems in affected children in addition to the high health care costs. Current treatment is based on surgical closure of the cleft followed by orthodontic dental care, speech therapy, bone grafting, and requires multiple surgeries spanning over 18 years. Thus, there is a pressing need to develop more effective methods of treatment to provide young patients with a safer option that will result in a complete closure of the palatal cleft shortly after birth. In this review, the application of the field of tissue engineering, involving the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) seeded on currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. This article presents the concise technique to generate new bone in cleft deformities, using stem cells. It also throws light on the work done by various researchers to regenerate bone in large defects.
VL  - 5
IS  - 4-1
ER  -

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Author Information

Rohit Raghavan

Department of Prosthodontics, Royal Dental College, Chalissery, Palakkad, Kerala
Sumitra S.

Department of Prosthodontics, Royal Dental College, Chalissery, Palakkad, Kerala
Nadeem Abdul Rahman

Department of Prosthodontics, Royal Dental College, Chalissery, Palakkad, Kerala
Justin Baby

Department of Prosthodontics, Royal Dental College, Chalissery, Palakkad, Kerala

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Plain Text BibTeX RIS

APA Style

Rohit Raghavan, Sumitra S., Nadeem Abdul Rahman, Justin Baby. (2016). Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Science Journal of Clinical Medicine, 5(4-1), 7-13. https://doi.org/10.11648/j.sjcm.s.2016050401.12

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ACS Style

Rohit Raghavan; Sumitra S.; Nadeem Abdul Rahman; Justin Baby. Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Sci. J. Clin. Med. 2016, 5(4-1), 7-13. doi: 10.11648/j.sjcm.s.2016050401.12

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AMA Style

Rohit Raghavan, Sumitra S., Nadeem Abdul Rahman, Justin Baby. Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review. Sci J Clin Med. 2016;5(4-1):7-13. doi: 10.11648/j.sjcm.s.2016050401.12

Copy | Download

@article{10.11648/j.sjcm.s.2016050401.12,
  author = {Rohit Raghavan and Sumitra S. and Nadeem Abdul Rahman and Justin Baby},
  title = {Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review},
  journal = {Science Journal of Clinical Medicine},
  volume = {5},
  number = {4-1},
  pages = {7-13},
  doi = {10.11648/j.sjcm.s.2016050401.12},
  url = {https://doi.org/10.11648/j.sjcm.s.2016050401.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.s.2016050401.12},
  abstract = {Of all the birth defects, Cleft palate is among the most common and affects about one in 1,500 births resulting in medical, physical, developmental, social and emotional problems in affected children in addition to the high health care costs. Current treatment is based on surgical closure of the cleft followed by orthodontic dental care, speech therapy, bone grafting, and requires multiple surgeries spanning over 18 years. Thus, there is a pressing need to develop more effective methods of treatment to provide young patients with a safer option that will result in a complete closure of the palatal cleft shortly after birth. In this review, the application of the field of tissue engineering, involving the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) seeded on currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. This article presents the concise technique to generate new bone in cleft deformities, using stem cells. It also throws light on the work done by various researchers to regenerate bone in large defects.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Forging a New Path in Cleft Rehabilitation by Tissue Engineering – A Review
AU  - Rohit Raghavan
AU  - Sumitra S.
AU  - Nadeem Abdul Rahman
AU  - Justin Baby
Y1  - 2016/04/16
PY  - 2016
N1  - https://doi.org/10.11648/j.sjcm.s.2016050401.12
DO  - 10.11648/j.sjcm.s.2016050401.12
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 7
EP  - 13
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.s.2016050401.12
AB  - Of all the birth defects, Cleft palate is among the most common and affects about one in 1,500 births resulting in medical, physical, developmental, social and emotional problems in affected children in addition to the high health care costs. Current treatment is based on surgical closure of the cleft followed by orthodontic dental care, speech therapy, bone grafting, and requires multiple surgeries spanning over 18 years. Thus, there is a pressing need to develop more effective methods of treatment to provide young patients with a safer option that will result in a complete closure of the palatal cleft shortly after birth. In this review, the application of the field of tissue engineering, involving the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) seeded on currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. This article presents the concise technique to generate new bone in cleft deformities, using stem cells. It also throws light on the work done by various researchers to regenerate bone in large defects.
VL  - 5
IS  - 4-1
ER  -

Copy | Download