Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal

Maria Adelina Costa; Carlos Fardilha; Graça Fonseca; Joao Conde; Carmen Calcada; Fatima Rodrigues; Paula Genesio; Fernanda Ponte; Joana Vale; Guilherme Campos; Carla Seixas; Andre Ferreira; Carla Sousa; Moreira Pinto; Paulo Costa

doi:doi:10.11648/j.sjcm.20190801.11

Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal

Maria Adelina Costa, Carlos Fardilha, Graça Fonseca, Joao Conde, Carmen Calcada, Fatima Rodrigues, Paula Genesio, Fernanda Ponte, Joana Vale, Guilherme Campos, Carla Seixas, Andre Ferreira, Carla Sousa, Moreira Pinto, Paulo Costa

Published in Science Journal of Clinical Medicine (Volume 8, Issue 1)

Received: 26 March 2019 Accepted: 6 May 2019 Published: 31 May 2019

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Abstract

Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.

Published in	Science Journal of Clinical Medicine (Volume 8, Issue 1)
DOI	10.11648/j.sjcm.20190801.11
Page(s)	1-5
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Radiotherapy, Hyperthermia, Locoregional Recurrence, Reirradiation

References

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[15]	C Zhao, J Chen, B Yu, et al. Improvement in quality of life in patients with nasopharyngeal carcinoma treated with non-invasive extracorporeal radiofrequency in combination with chemoradiotherapy. Int J Radiat Biol (2014) 90(10):853–8.
[16]	M Kang, WQ Liu, YT Qin, et al. Long-term efficacy of microwave hyperthermia combined with chemoradiotherapy in treatment of nasopharyngeal carcinoma with cervical lymph node metastases. Asian Pac J Cancer Prev (2013) 14(12):7395–400.
[17]	Linthorst M, Baaijens M, Wiggenraad R, et al. Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients. Radiotherapy and Oncology (2015) 117: 217-222.
[18]	Peeken JC, Vaupel P, Combs SE. Integrating hyperthermia into modern radiation oncology: what evidence is necessary? Frontiers in Oncology (2017) 7(132): 1-12.

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Maria Adelina Costa, Carlos Fardilha, Graça Fonseca, Joao Conde, Carmen Calcada, et al. (2019). Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Science Journal of Clinical Medicine, 8(1), 1-5. https://doi.org/10.11648/j.sjcm.20190801.11

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ACS Style

Maria Adelina Costa; Carlos Fardilha; Graça Fonseca; Joao Conde; Carmen Calcada, et al. Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Sci. J. Clin. Med. 2019, 8(1), 1-5. doi: 10.11648/j.sjcm.20190801.11

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AMA Style

Maria Adelina Costa, Carlos Fardilha, Graça Fonseca, Joao Conde, Carmen Calcada, et al. Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Sci J Clin Med. 2019;8(1):1-5. doi: 10.11648/j.sjcm.20190801.11

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@article{10.11648/j.sjcm.20190801.11,
  author = {Maria Adelina Costa and Carlos Fardilha and Graça Fonseca and Joao Conde and Carmen Calcada and Fatima Rodrigues and Paula Genesio and Fernanda Ponte and Joana Vale and Guilherme Campos and Carla Seixas and Andre Ferreira and Carla Sousa and Moreira Pinto and Paulo Costa},
  title = {Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal},
  journal = {Science Journal of Clinical Medicine},
  volume = {8},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.sjcm.20190801.11},
  url = {https://doi.org/10.11648/j.sjcm.20190801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20190801.11},
  abstract = {Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.},
 year = {2019}
}

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TY  - JOUR
T1  - Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal
AU  - Maria Adelina Costa
AU  - Carlos Fardilha
AU  - Graça Fonseca
AU  - Joao Conde
AU  - Carmen Calcada
AU  - Fatima Rodrigues
AU  - Paula Genesio
AU  - Fernanda Ponte
AU  - Joana Vale
AU  - Guilherme Campos
AU  - Carla Seixas
AU  - Andre Ferreira
AU  - Carla Sousa
AU  - Moreira Pinto
AU  - Paulo Costa
Y1  - 2019/05/31
PY  - 2019
N1  - https://doi.org/10.11648/j.sjcm.20190801.11
DO  - 10.11648/j.sjcm.20190801.11
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20190801.11
AB  - Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.
VL  - 8
IS  - 1
ER  -

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Author Information

Maria Adelina Costa

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Carlos Fardilha

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Graça Fonseca
Joao Conde

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Carmen Calcada

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Fatima Rodrigues

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Paula Genesio

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Fernanda Ponte

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Joana Vale

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Guilherme Campos

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal
Carla Seixas

Medical Oncology Service, Hospital CUF, Porto, Portugal
Andre Ferreira

Medical Oncology Service, Hospital CUF, Porto, Portugal
Carla Sousa

Medical Oncology Service, Hospital CUF, Porto, Portugal
Moreira Pinto

Medical Oncology Service, Hospital CUF, Porto, Portugal
Paulo Costa

Radiation Oncology Department Julio Teixeira, CUF Institute, Porto, Portugal

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Plain Text BibTeX RIS

APA Style

Maria Adelina Costa, Carlos Fardilha, Graça Fonseca, Joao Conde, Carmen Calcada, et al. (2019). Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Science Journal of Clinical Medicine, 8(1), 1-5. https://doi.org/10.11648/j.sjcm.20190801.11

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ACS Style

Maria Adelina Costa; Carlos Fardilha; Graça Fonseca; Joao Conde; Carmen Calcada, et al. Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Sci. J. Clin. Med. 2019, 8(1), 1-5. doi: 10.11648/j.sjcm.20190801.11

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AMA Style

Maria Adelina Costa, Carlos Fardilha, Graça Fonseca, Joao Conde, Carmen Calcada, et al. Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal. Sci J Clin Med. 2019;8(1):1-5. doi: 10.11648/j.sjcm.20190801.11

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@article{10.11648/j.sjcm.20190801.11,
  author = {Maria Adelina Costa and Carlos Fardilha and Graça Fonseca and Joao Conde and Carmen Calcada and Fatima Rodrigues and Paula Genesio and Fernanda Ponte and Joana Vale and Guilherme Campos and Carla Seixas and Andre Ferreira and Carla Sousa and Moreira Pinto and Paulo Costa},
  title = {Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal},
  journal = {Science Journal of Clinical Medicine},
  volume = {8},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.sjcm.20190801.11},
  url = {https://doi.org/10.11648/j.sjcm.20190801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20190801.11},
  abstract = {Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Radiotherapy and Hyperthermia in the Treatment of Locoregional Recurrent Cancer-Report of the First Patients Treated in Portugal
AU  - Maria Adelina Costa
AU  - Carlos Fardilha
AU  - Graça Fonseca
AU  - Joao Conde
AU  - Carmen Calcada
AU  - Fatima Rodrigues
AU  - Paula Genesio
AU  - Fernanda Ponte
AU  - Joana Vale
AU  - Guilherme Campos
AU  - Carla Seixas
AU  - Andre Ferreira
AU  - Carla Sousa
AU  - Moreira Pinto
AU  - Paulo Costa
Y1  - 2019/05/31
PY  - 2019
N1  - https://doi.org/10.11648/j.sjcm.20190801.11
DO  - 10.11648/j.sjcm.20190801.11
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20190801.11
AB  - Background and purpose: The association of hyperthermia with radiotherapy has been shown to be a valid approach in the treatment of locoregional recurrence of previously irradiated malignant tumors. The purpose of the present study is to describe the initial experience of the Radiation Oncology Department Júlio Teixeira SA (CUF Institute) and the Medical Oncology Service (Hospital CUF Porto) in the treatment of these lesions, reporting the first cases treated in Portugal with this therapeutic approach. Material and methods: The authors performed a retrospective analysis of the 18 patients, 16 females and 2 males, with unresectable tumor recurrences, in previously irradiated areas, treated with radiotherapy associated with hyperthermia between May 2016 and March 2017, totalizing 25 treatments. Breast disease was the most frequent, accounting for 72% of cases. Results: The median follow-up period was 4, 5 months. The complete response rate was 44%. A favorable response was observed in all treatments, with decrease in pain, bleeding and infection, with and no grade 3 toxicities. Conclusions: The results are encouraging, with improved quality of life and patient self-esteem with acceptable toxicity. The combined treatment of hyperthermia and radiotherapy seems to be a valid option in the local control of recurrent unresectable neoplasms at previously irradiated sites, whose therapeutic options are limited.
VL  - 8
IS  - 1
ER  -

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