General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells

Fernández-Lázaro Diego; Fernández-Lázaro César Ignacio

doi:doi:10.11648/j.crj.20180603.15

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General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells

Fernández-Lázaro Diego, Fernández-Lázaro César Ignacio

Published in Cancer Research Journal (Volume 6, Issue 3)

Received: 27 July 2018 Accepted: 9 August 2018 Published: 6 September 2018

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Abstract

The management of cancer involves procedures, which include surgery, radiotherapy and chemotherapy, whose are aimed at destroying tumor cells and preserving healthy tissues. Development of drug resistance is one of problems during the treatment of local and/or disseminated disease, also is one of the biggest problems in relapses of cancer. A plethora of cytotoxic drugs that selectively, but not exclusively, target actively proliferating cells include such diverse groups as DNA alkylating agents, antimetabolites, intercalating agents and mitotic inhibitors. Resistance constitutes a lack of response to drug-induced tumor growth inhibition. This article discusses the various mechanisms of acquired drug resistance that have been reported in the context of cancer drug therapies. The drug resistance may be inherent in a subpopulation of heterogeneous cancer cells or be acquired as a cellular response to drug exposure. Also, different mechanisms have been proposed that could explain tumor refractoriness due to resistance to anti-tumor drugs, some of them are: intrinsic resistance due to their genetic characteristics, acquisition of resistance mechanisms after exposure to a drug, mechanisms that alter transport of the drug. drug through the plasma membrane, DNA repair, alterations in target molecules, difficulty of the drug to access the target cells and growth factors. The knowledge of these mechanisms of resistance, could serve as a therapeutic strategy to control or delay the progression of the disease and therefore improve the quality of life of the patient.

Published in	Cancer Research Journal (Volume 6, Issue 3)
DOI	10.11648/j.crj.20180603.15
Page(s)	101-105
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cancer, Chemotherapy, Pharmacological Resistance, Tumor Cell

References

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APA Style

Fernández-Lázaro Diego, Fernández-Lázaro César Ignacio. (2018). General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells. Cancer Research Journal, 6(3), 101-105. https://doi.org/10.11648/j.crj.20180603.15

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ACS Style

Fernández-Lázaro Diego; Fernández-Lázaro César Ignacio. General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells. Cancer Res. J. 2018, 6(3), 101-105. doi: 10.11648/j.crj.20180603.15

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AMA Style

Fernández-Lázaro Diego, Fernández-Lázaro César Ignacio. General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells. Cancer Res J. 2018;6(3):101-105. doi: 10.11648/j.crj.20180603.15

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@article{10.11648/j.crj.20180603.15,
  author = {Fernández-Lázaro Diego and Fernández-Lázaro César Ignacio},
  title = {General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells},
  journal = {Cancer Research Journal},
  volume = {6},
  number = {3},
  pages = {101-105},
  doi = {10.11648/j.crj.20180603.15},
  url = {https://doi.org/10.11648/j.crj.20180603.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20180603.15},
  abstract = {The management of cancer involves procedures, which include surgery, radiotherapy and chemotherapy, whose are aimed at destroying tumor cells and preserving healthy tissues. Development of drug resistance is one of problems during the treatment of local and/or disseminated disease, also is one of the biggest problems in relapses of cancer. A plethora of cytotoxic drugs that selectively, but not exclusively, target actively proliferating cells include such diverse groups as DNA alkylating agents, antimetabolites, intercalating agents and mitotic inhibitors. Resistance constitutes a lack of response to drug-induced tumor growth inhibition. This article discusses the various mechanisms of acquired drug resistance that have been reported in the context of cancer drug therapies. The drug resistance may be inherent in a subpopulation of heterogeneous cancer cells or be acquired as a cellular response to drug exposure. Also, different mechanisms have been proposed that could explain tumor refractoriness due to resistance to anti-tumor drugs, some of them are: intrinsic resistance due to their genetic characteristics, acquisition of resistance mechanisms after exposure to a drug, mechanisms that alter transport of the drug. drug through the plasma membrane, DNA repair, alterations in target molecules, difficulty of the drug to access the target cells and growth factors. The knowledge of these mechanisms of resistance, could serve as a therapeutic strategy to control or delay the progression of the disease and therefore improve the quality of life of the patient.},
 year = {2018}
}

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TY  - JOUR
T1  - General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells
AU  - Fernández-Lázaro Diego
AU  - Fernández-Lázaro César Ignacio
Y1  - 2018/09/06
PY  - 2018
N1  - https://doi.org/10.11648/j.crj.20180603.15
DO  - 10.11648/j.crj.20180603.15
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 101
EP  - 105
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20180603.15
AB  - The management of cancer involves procedures, which include surgery, radiotherapy and chemotherapy, whose are aimed at destroying tumor cells and preserving healthy tissues. Development of drug resistance is one of problems during the treatment of local and/or disseminated disease, also is one of the biggest problems in relapses of cancer. A plethora of cytotoxic drugs that selectively, but not exclusively, target actively proliferating cells include such diverse groups as DNA alkylating agents, antimetabolites, intercalating agents and mitotic inhibitors. Resistance constitutes a lack of response to drug-induced tumor growth inhibition. This article discusses the various mechanisms of acquired drug resistance that have been reported in the context of cancer drug therapies. The drug resistance may be inherent in a subpopulation of heterogeneous cancer cells or be acquired as a cellular response to drug exposure. Also, different mechanisms have been proposed that could explain tumor refractoriness due to resistance to anti-tumor drugs, some of them are: intrinsic resistance due to their genetic characteristics, acquisition of resistance mechanisms after exposure to a drug, mechanisms that alter transport of the drug. drug through the plasma membrane, DNA repair, alterations in target molecules, difficulty of the drug to access the target cells and growth factors. The knowledge of these mechanisms of resistance, could serve as a therapeutic strategy to control or delay the progression of the disease and therefore improve the quality of life of the patient.
VL  - 6
IS  - 3
ER  -

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Author Information

Fernández-Lázaro Diego

Department of Cell Biology, Histology and Pharmacology, Faculty of Physiotherapy, University of Valladolid, Soria, Spain
Fernández-Lázaro César Ignacio

Department of Cell Biology, Histology and Pharmacology, Faculty of Physiotherapy, University of Valladolid, Soria, Spain

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Plain Text BibTeX RIS

APA Style

Fernández-Lázaro Diego, Fernández-Lázaro César Ignacio. (2018). General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells. Cancer Research Journal, 6(3), 101-105. https://doi.org/10.11648/j.crj.20180603.15

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ACS Style

Fernández-Lázaro Diego; Fernández-Lázaro César Ignacio. General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells. Cancer Res. J. 2018, 6(3), 101-105. doi: 10.11648/j.crj.20180603.15

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AMA Style

Fernández-Lázaro Diego, Fernández-Lázaro César Ignacio. General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells. Cancer Res J. 2018;6(3):101-105. doi: 10.11648/j.crj.20180603.15

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@article{10.11648/j.crj.20180603.15,
  author = {Fernández-Lázaro Diego and Fernández-Lázaro César Ignacio},
  title = {General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells},
  journal = {Cancer Research Journal},
  volume = {6},
  number = {3},
  pages = {101-105},
  doi = {10.11648/j.crj.20180603.15},
  url = {https://doi.org/10.11648/j.crj.20180603.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20180603.15},
  abstract = {The management of cancer involves procedures, which include surgery, radiotherapy and chemotherapy, whose are aimed at destroying tumor cells and preserving healthy tissues. Development of drug resistance is one of problems during the treatment of local and/or disseminated disease, also is one of the biggest problems in relapses of cancer. A plethora of cytotoxic drugs that selectively, but not exclusively, target actively proliferating cells include such diverse groups as DNA alkylating agents, antimetabolites, intercalating agents and mitotic inhibitors. Resistance constitutes a lack of response to drug-induced tumor growth inhibition. This article discusses the various mechanisms of acquired drug resistance that have been reported in the context of cancer drug therapies. The drug resistance may be inherent in a subpopulation of heterogeneous cancer cells or be acquired as a cellular response to drug exposure. Also, different mechanisms have been proposed that could explain tumor refractoriness due to resistance to anti-tumor drugs, some of them are: intrinsic resistance due to their genetic characteristics, acquisition of resistance mechanisms after exposure to a drug, mechanisms that alter transport of the drug. drug through the plasma membrane, DNA repair, alterations in target molecules, difficulty of the drug to access the target cells and growth factors. The knowledge of these mechanisms of resistance, could serve as a therapeutic strategy to control or delay the progression of the disease and therefore improve the quality of life of the patient.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - General Mechanisms of Resistance to Pharmacological Therapy Applied to Tumor Cells
AU  - Fernández-Lázaro Diego
AU  - Fernández-Lázaro César Ignacio
Y1  - 2018/09/06
PY  - 2018
N1  - https://doi.org/10.11648/j.crj.20180603.15
DO  - 10.11648/j.crj.20180603.15
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 101
EP  - 105
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20180603.15
AB  - The management of cancer involves procedures, which include surgery, radiotherapy and chemotherapy, whose are aimed at destroying tumor cells and preserving healthy tissues. Development of drug resistance is one of problems during the treatment of local and/or disseminated disease, also is one of the biggest problems in relapses of cancer. A plethora of cytotoxic drugs that selectively, but not exclusively, target actively proliferating cells include such diverse groups as DNA alkylating agents, antimetabolites, intercalating agents and mitotic inhibitors. Resistance constitutes a lack of response to drug-induced tumor growth inhibition. This article discusses the various mechanisms of acquired drug resistance that have been reported in the context of cancer drug therapies. The drug resistance may be inherent in a subpopulation of heterogeneous cancer cells or be acquired as a cellular response to drug exposure. Also, different mechanisms have been proposed that could explain tumor refractoriness due to resistance to anti-tumor drugs, some of them are: intrinsic resistance due to their genetic characteristics, acquisition of resistance mechanisms after exposure to a drug, mechanisms that alter transport of the drug. drug through the plasma membrane, DNA repair, alterations in target molecules, difficulty of the drug to access the target cells and growth factors. The knowledge of these mechanisms of resistance, could serve as a therapeutic strategy to control or delay the progression of the disease and therefore improve the quality of life of the patient.
VL  - 6
IS  - 3
ER  -

Copy | Download