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Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review

Received: 21 November 2014    Accepted: 08 December 2014    Published: 27 December 2014
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Abstract

Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus family. After its discovery and detection in approximately 80% of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and aggressive skin cancer that primarily affects elderly and immunosuppressed people. In this study, a systematic review was developed to gather and evidence information about the involvement of MCV infection in the development of MCC. An analysis was performed in the PubMed database in order to find articles to answer the purpose of this present study. Ninety-seven articles met the criteria, forty-six of them investigated the prevalence of MCV in MCC clinical samples, and all showed that the MCV-MCC association exists, with the viral presence ranging from 18 to 100% in MCC tumors. In addition, results pointing to the MCV potential carcinogenic, infection, transmission and replication mechanisms, or even possible disease markers or therapeutic evaluations were found. Current literature has demonstrated frequent involvement of MCV in MCC, with survey of some disease indicative laboratory markers and possible therapeutic evaluations.

DOI 10.11648/j.crj.s.2014020601.11
Published in Cancer Research Journal (Volume 2, Issue 6-1, December 2014)

This article belongs to the Special Issue Lifestyle and Cancer Risk

Page(s) 1-10
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Merkel Cell Carcinoma, Merkel Cell Polyomavirus, Carcinogenesis

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  • Pharmacy Department, Masters Program in Pharmaceutical Sciences, Universidade Estadual do Centro-Oeste (State University of Center-West) (UNICENTRO), Guarapuava-PR, Brazil

  • Pharmacy Department, Masters Program in Pharmaceutical Sciences, Universidade Estadual do Centro-Oeste (State University of Center-West) (UNICENTRO), Guarapuava-PR, Brazil

  • Pharmacy Department, Masters Program in Pharmaceutical Sciences, Universidade Estadual do Centro-Oeste (State University of Center-West) (UNICENTRO), Guarapuava-PR, Brazil

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    Fernando Seiji Morais, Caio Santos Bonilha, Emerson Carraro. (2014). Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Research Journal, 2(6-1), 1-10. https://doi.org/10.11648/j.crj.s.2014020601.11

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    Fernando Seiji Morais; Caio Santos Bonilha; Emerson Carraro. Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Res. J. 2014, 2(6-1), 1-10. doi: 10.11648/j.crj.s.2014020601.11

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    Fernando Seiji Morais, Caio Santos Bonilha, Emerson Carraro. Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Res J. 2014;2(6-1):1-10. doi: 10.11648/j.crj.s.2014020601.11

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  • @article{10.11648/j.crj.s.2014020601.11,
      author = {Fernando Seiji Morais and Caio Santos Bonilha and Emerson Carraro},
      title = {Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review},
      journal = {Cancer Research Journal},
      volume = {2},
      number = {6-1},
      pages = {1-10},
      doi = {10.11648/j.crj.s.2014020601.11},
      url = {https://doi.org/10.11648/j.crj.s.2014020601.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.crj.s.2014020601.11},
      abstract = {Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus family. After its discovery and detection in approximately 80% of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and aggressive skin cancer that primarily affects elderly and immunosuppressed people. In this study, a systematic review was developed to gather and evidence information about the involvement of MCV infection in the development of MCC. An analysis was performed in the PubMed database in order to find articles to answer the purpose of this present study. Ninety-seven articles met the criteria, forty-six of them investigated the prevalence of MCV in MCC clinical samples, and all showed that the MCV-MCC association exists, with the viral presence ranging from 18 to 100% in MCC tumors. In addition, results pointing to the MCV potential carcinogenic, infection, transmission and replication mechanisms, or even possible disease markers or therapeutic evaluations were found. Current literature has demonstrated frequent involvement of MCV in MCC, with survey of some disease indicative laboratory markers and possible therapeutic evaluations.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review
    AU  - Fernando Seiji Morais
    AU  - Caio Santos Bonilha
    AU  - Emerson Carraro
    Y1  - 2014/12/27
    PY  - 2014
    N1  - https://doi.org/10.11648/j.crj.s.2014020601.11
    DO  - 10.11648/j.crj.s.2014020601.11
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 1
    EP  - 10
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.s.2014020601.11
    AB  - Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus family. After its discovery and detection in approximately 80% of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and aggressive skin cancer that primarily affects elderly and immunosuppressed people. In this study, a systematic review was developed to gather and evidence information about the involvement of MCV infection in the development of MCC. An analysis was performed in the PubMed database in order to find articles to answer the purpose of this present study. Ninety-seven articles met the criteria, forty-six of them investigated the prevalence of MCV in MCC clinical samples, and all showed that the MCV-MCC association exists, with the viral presence ranging from 18 to 100% in MCC tumors. In addition, results pointing to the MCV potential carcinogenic, infection, transmission and replication mechanisms, or even possible disease markers or therapeutic evaluations were found. Current literature has demonstrated frequent involvement of MCV in MCC, with survey of some disease indicative laboratory markers and possible therapeutic evaluations.
    VL  - 2
    IS  - 6-1
    ER  - 

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