Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos

Francisco Tria IV; Daphne Ang; Jose Jasper Andal; Frances Victoria Que; Loraine Kay Cabral; Rosil Dimalibot; Rachelle Arah Salamat; Ma. Luisa Enriquez; Sharlynne Bandales; Raymundo Lo; Manuelito Madrid; Marcelo Imasa; Rubi Li

doi:doi:10.11648/j.crj.20190703.12

Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos

Francisco Tria IV, Daphne Ang, Jose Jasper Andal, Frances Victoria Que, Loraine Kay Cabral, Rosil Dimalibot, Rachelle Arah Salamat, Ma. Luisa Enriquez, Sharlynne Bandales, Raymundo Lo, Manuelito Madrid, Marcelo Imasa, Rubi Li

Published in Cancer Research Journal (Volume 7, Issue 3)

Received: 6 July 2019 Accepted: 25 July 2019 Published: 10 August 2019

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Abstract

The presence of germline mutations in the BRCA1 or BRCA2 tumor suppressor genes are strong predictors of breast or ovarian cancer risk. Loss of the wild-type allele of BRCA1 or BRCA2 genes are required for tumorigenesis. This study identified and characterized the germline BRCA1 and BRCA2 mutation spectrum among Filipinos using Next Generation Sequencing. This is the first local study to perform comprehensive BRCA1 and BRCA 2 (all exons) mutational analysis among Filipinos. This study prompts further investigation of the unique variants to enable better understanding of the genetic predisposition to BC among Filipinos.

Published in	Cancer Research Journal (Volume 7, Issue 3)
DOI	10.11648/j.crj.20190703.12
Page(s)	79-86
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hereditary Breast and Ovarian Cancer Syndrome (HBOC), BRCA1 and BRCA2 Genes, Next Generation Sequencing (NGS), Filipino Breast Cancer

References

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APA Style

Francisco Tria IV, Daphne Ang, Jose Jasper Andal, Frances Victoria Que, Loraine Kay Cabral, et al. (2019). Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos. Cancer Research Journal, 7(3), 79-86. https://doi.org/10.11648/j.crj.20190703.12

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ACS Style

Francisco Tria IV; Daphne Ang; Jose Jasper Andal; Frances Victoria Que; Loraine Kay Cabral, et al. Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos. Cancer Res. J. 2019, 7(3), 79-86. doi: 10.11648/j.crj.20190703.12

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AMA Style

Francisco Tria IV, Daphne Ang, Jose Jasper Andal, Frances Victoria Que, Loraine Kay Cabral, et al. Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos. Cancer Res J. 2019;7(3):79-86. doi: 10.11648/j.crj.20190703.12

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@article{10.11648/j.crj.20190703.12,
  author = {Francisco Tria IV and Daphne Ang and Jose Jasper Andal and Frances Victoria Que and Loraine Kay Cabral and Rosil Dimalibot and Rachelle Arah Salamat and Ma. Luisa Enriquez and Sharlynne Bandales and Raymundo Lo and Manuelito Madrid and Marcelo Imasa and Rubi Li},
  title = {Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos},
  journal = {Cancer Research Journal},
  volume = {7},
  number = {3},
  pages = {79-86},
  doi = {10.11648/j.crj.20190703.12},
  url = {https://doi.org/10.11648/j.crj.20190703.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190703.12},
  abstract = {The presence of germline mutations in the BRCA1 or BRCA2 tumor suppressor genes are strong predictors of breast or ovarian cancer risk. Loss of the wild-type allele of BRCA1 or BRCA2 genes are required for tumorigenesis. This study identified and characterized the germline BRCA1 and BRCA2 mutation spectrum among Filipinos using Next Generation Sequencing. This is the first local study to perform comprehensive BRCA1 and BRCA 2 (all exons) mutational analysis among Filipinos. This study prompts further investigation of the unique variants to enable better understanding of the genetic predisposition to BC among Filipinos.},
 year = {2019}
}

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TY  - JOUR
T1  - Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos
AU  - Francisco Tria IV
AU  - Daphne Ang
AU  - Jose Jasper Andal
AU  - Frances Victoria Que
AU  - Loraine Kay Cabral
AU  - Rosil Dimalibot
AU  - Rachelle Arah Salamat
AU  - Ma. Luisa Enriquez
AU  - Sharlynne Bandales
AU  - Raymundo Lo
AU  - Manuelito Madrid
AU  - Marcelo Imasa
AU  - Rubi Li
Y1  - 2019/08/10
PY  - 2019
N1  - https://doi.org/10.11648/j.crj.20190703.12
DO  - 10.11648/j.crj.20190703.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 79
EP  - 86
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20190703.12
AB  - The presence of germline mutations in the BRCA1 or BRCA2 tumor suppressor genes are strong predictors of breast or ovarian cancer risk. Loss of the wild-type allele of BRCA1 or BRCA2 genes are required for tumorigenesis. This study identified and characterized the germline BRCA1 and BRCA2 mutation spectrum among Filipinos using Next Generation Sequencing. This is the first local study to perform comprehensive BRCA1 and BRCA 2 (all exons) mutational analysis among Filipinos. This study prompts further investigation of the unique variants to enable better understanding of the genetic predisposition to BC among Filipinos.
VL  - 7
IS  - 3
ER  -

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Author Information

Francisco Tria IV

Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Daphne Ang

Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Jose Jasper Andal

Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Frances Victoria Que

Department of Medical Oncology, St. Luke’s Medical Center, Quezon City, Philippines
Loraine Kay Cabral

Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
Rosil Dimalibot

Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Rachelle Arah Salamat

Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Ma. Luisa Enriquez

Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
Sharlynne Bandales

Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
Raymundo Lo

Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Manuelito Madrid

Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Marcelo Imasa

Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
Rubi Li

Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines

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Plain Text BibTeX RIS

APA Style

Francisco Tria IV, Daphne Ang, Jose Jasper Andal, Frances Victoria Que, Loraine Kay Cabral, et al. (2019). Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos. Cancer Research Journal, 7(3), 79-86. https://doi.org/10.11648/j.crj.20190703.12

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ACS Style

Francisco Tria IV; Daphne Ang; Jose Jasper Andal; Frances Victoria Que; Loraine Kay Cabral, et al. Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos. Cancer Res. J. 2019, 7(3), 79-86. doi: 10.11648/j.crj.20190703.12

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AMA Style

Francisco Tria IV, Daphne Ang, Jose Jasper Andal, Frances Victoria Que, Loraine Kay Cabral, et al. Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos. Cancer Res J. 2019;7(3):79-86. doi: 10.11648/j.crj.20190703.12

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@article{10.11648/j.crj.20190703.12,
  author = {Francisco Tria IV and Daphne Ang and Jose Jasper Andal and Frances Victoria Que and Loraine Kay Cabral and Rosil Dimalibot and Rachelle Arah Salamat and Ma. Luisa Enriquez and Sharlynne Bandales and Raymundo Lo and Manuelito Madrid and Marcelo Imasa and Rubi Li},
  title = {Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos},
  journal = {Cancer Research Journal},
  volume = {7},
  number = {3},
  pages = {79-86},
  doi = {10.11648/j.crj.20190703.12},
  url = {https://doi.org/10.11648/j.crj.20190703.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190703.12},
  abstract = {The presence of germline mutations in the BRCA1 or BRCA2 tumor suppressor genes are strong predictors of breast or ovarian cancer risk. Loss of the wild-type allele of BRCA1 or BRCA2 genes are required for tumorigenesis. This study identified and characterized the germline BRCA1 and BRCA2 mutation spectrum among Filipinos using Next Generation Sequencing. This is the first local study to perform comprehensive BRCA1 and BRCA 2 (all exons) mutational analysis among Filipinos. This study prompts further investigation of the unique variants to enable better understanding of the genetic predisposition to BC among Filipinos.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos
AU  - Francisco Tria IV
AU  - Daphne Ang
AU  - Jose Jasper Andal
AU  - Frances Victoria Que
AU  - Loraine Kay Cabral
AU  - Rosil Dimalibot
AU  - Rachelle Arah Salamat
AU  - Ma. Luisa Enriquez
AU  - Sharlynne Bandales
AU  - Raymundo Lo
AU  - Manuelito Madrid
AU  - Marcelo Imasa
AU  - Rubi Li
Y1  - 2019/08/10
PY  - 2019
N1  - https://doi.org/10.11648/j.crj.20190703.12
DO  - 10.11648/j.crj.20190703.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 79
EP  - 86
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20190703.12
AB  - The presence of germline mutations in the BRCA1 or BRCA2 tumor suppressor genes are strong predictors of breast or ovarian cancer risk. Loss of the wild-type allele of BRCA1 or BRCA2 genes are required for tumorigenesis. This study identified and characterized the germline BRCA1 and BRCA2 mutation spectrum among Filipinos using Next Generation Sequencing. This is the first local study to perform comprehensive BRCA1 and BRCA 2 (all exons) mutational analysis among Filipinos. This study prompts further investigation of the unique variants to enable better understanding of the genetic predisposition to BC among Filipinos.
VL  - 7
IS  - 3
ER  -

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