Extensive Bone Lesions and Skin Lesions Revealing an Acute Transformation of an Extramedullary Chronic Myeloid Leukemia
Cancer Research Journal
Volume 6, Issue 2, June 2018, Pages: 70-73
Received: Mar. 13, 2018;
Accepted: Mar. 29, 2018;
Published: May 5, 2018
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Bienvenu Houssou, Department of Clinical Hematology and Pediatric Oncology, Hospital August 20th 1953, University Hassan II, Casablanca, Morocco
Mouna Lamchahab, Department of Clinical Hematology and Pediatric Oncology, Hospital August 20th 1953, University Hassan II, Casablanca, Morocco
Halima Hadri, Department of Clinical Hematology and Pediatric Oncology, Hospital August 20th 1953, University Hassan II, Casablanca, Morocco
Boubker Messoudi, Department of Trauma and Orthopedic of the Hospital Ibn Rochd, University Hassan II, Casablanca, Morocco
Abdeljabbar Messoudi, Department of Trauma and Orthopedic of the Hospital Ibn Rochd, University Hassan II, Casablanca, Morocco
Asma Quessar, Department of Clinical Hematology and Pediatric Oncology, Hospital August 20th 1953, University Hassan II, Casablanca, Morocco
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Extramedullary blast transformation as the initial presentation of Chronic Myeloid Leukemia with bone marrow remaining in the chronic phase is an unusual event. We report the case of a 30-year-old with chronic CML at the medullary level and an acute transformation revealed by extensive bone lyses and skin lesions. A 30-year-old man had cutaneous nodules, functional impotence and paresis. Radiological investigations revealed osteolytic lesions of the right humeral head, right clavicle, ribs, C5 and C7 vertebrae with medullary compression. Anatomo-pathological study and immunohistochemistry of nodules and osteolytic lesions resulted in granulocytic sarcoma with CD10 +, CD34 +, CD13 +, CD33 +, CD117 and MPO positive. The myelogram was in favor of chronic phase CML. He was put on imatinib, the chemotherapy could not be started because his condition was impaired and he dies by metabolic disorder. The acute transformation of chronic phase CML into extra marrow remains unusual. The care is a real challenge hence the need for consensual recommendations.
Acute Transformation, Chronic Myeloid Leukemia, Bones lesions, Skin Lesions
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Extensive Bone Lesions and Skin Lesions Revealing an Acute Transformation of an Extramedullary Chronic Myeloid Leukemia, Cancer Research Journal.
Vol. 6, No. 2,
2018, pp. 70-73.
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
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