Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells
Cancer Research Journal
Volume 4, Issue 5, September 2016, Pages: 69-72
Received: Aug. 4, 2016; Accepted: Aug. 26, 2016; Published: Sep. 21, 2016
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Authors
Torricelli Piera, Department SPES, University of Molise, Campobasso, Italy
Ferorelli Pasquale, University of Tor Vergata, Department of Biology, Rome, Italy
Shevchenko Anna, People’s Friendship University of Russia, Moscow, Russia
Antonelli Francesco, University of Tor Vergata, Department of Biology, Rome, Italy
Siciliano Alberto, University of Tor Vergata, Department of Biology, Rome, Italy
De Martino Angelo, University of Tor Vergata, Department of Biology, Rome, Italy
Beninati Simone, University of Tor Vergata, Department of Biology, Rome, Italy
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Abstract
Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.
Keywords
Antioxidants, Organ Perfusion, Oxidative Stress, Micronutrients, HCC, Hepatocarcinoma
To cite this article
Torricelli Piera, Ferorelli Pasquale, Shevchenko Anna, Antonelli Francesco, Siciliano Alberto, De Martino Angelo, Beninati Simone, Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells, Cancer Research Journal. Vol. 4, No. 5, 2016, pp. 69-72. doi: 10.11648/j.crj.20160405.11
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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