Cancer Research Journal

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Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line

Received: 02 February 2016    Accepted: 18 February 2016    Published: 01 March 2016
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Abstract

Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.

DOI 10.11648/j.crj.20160402.11
Published in Cancer Research Journal (Volume 4, Issue 2, March 2016)
Page(s) 28-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Water Garlic Extract, Copper, HepG2, p53, p21, AIF

References
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Author Information
  • Department of Biology, University of Rome “Tor Vergata”, Rome, Italy

  • Department SPES, University of Molise, Campobasso, Italy

  • Faculty of Science, Botany Department, Alexandria University, Alexandria, Egypt

  • People’s Friendship University of Russia, Moscow, Russia

  • Department of Biology, University of Rome “Tor Vergata”, Rome, Italy

  • Department of Biology, University of Rome “Tor Vergata”, Rome, Italy

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    Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, et al. (2016). Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Research Journal, 4(2), 28-31. https://doi.org/10.11648/j.crj.20160402.11

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    ACS Style

    Angelo De Martino; Piera Torricelli; Hanan Mahmoud Abu-Zeid; Anna Shevchenko; Alberto Siciliano, et al. Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Res. J. 2016, 4(2), 28-31. doi: 10.11648/j.crj.20160402.11

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    AMA Style

    Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, et al. Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Res J. 2016;4(2):28-31. doi: 10.11648/j.crj.20160402.11

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  • @article{10.11648/j.crj.20160402.11,
      author = {Angelo De Martino and Piera Torricelli and Hanan Mahmoud Abu-Zeid and Anna Shevchenko and Alberto Siciliano and Simone Beninati},
      title = {Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line},
      journal = {Cancer Research Journal},
      volume = {4},
      number = {2},
      pages = {28-31},
      doi = {10.11648/j.crj.20160402.11},
      url = {https://doi.org/10.11648/j.crj.20160402.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.crj.20160402.11},
      abstract = {Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.},
     year = {2016}
    }
    

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    AU  - Angelo De Martino
    AU  - Piera Torricelli
    AU  - Hanan Mahmoud Abu-Zeid
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    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
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    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.crj.20160402.11
    AB  - Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.
    VL  - 4
    IS  - 2
    ER  - 

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