The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous

Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas’ud

doi:doi:10.11648/j.crj.20150304.12

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The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous

Imanuel Berly Delvis Kapelle, Tun Tedja Irawadi, Meika Syahbana Rusli, Djumali Mangunwidjaja, Zainal Alim Mas’ud

Published in Cancer Research Journal (Volume 3, Issue 4)

Received: 1 June 2015 Accepted: 18 June 2015 Published: 4 July 2015

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Abstract

Activity anticancer of curcumin analogous influenced by the structure, substituent and geometric isomeric. The purpose of this research was to determine the influence of curcumin analog synthesis methods against anti-cancer activity. The value of IC50 tested in vitro against breast cancer cells T47D uses the MTT method for samples aks (1,5-bis-benzo[1.3]dioxol-5-yl-penta-1,4-dien-3-one) with a method of the process of microwave 257,798 µg/ml better than conventional method 555,276 µg/ml. The results IC50 for samples akas (5-benzo 1.3 dioxol-5-yl-1-phenyl-penta-2,4-dien-1-one) with a method of microwave 7,247 µg/ml better than conventional method 125,300 µg/ml. Microwave method produces a product with a lower melting point and provide the results of anti-cancer activity against breast cancer cells T47D.

Published in	Cancer Research Journal (Volume 3, Issue 4)
DOI	10.11648/j.crj.20150304.12
Page(s)	68-75
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Anticancer Activity, In Vitro, curcumin analogous

References

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APA Style

Imanuel Berly Delvis Kapelle, Tun Tedja Irawadi, Meika Syahbana Rusli, Djumali Mangunwidjaja, Zainal Alim Mas’ud. (2015). The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous. Cancer Research Journal, 3(4), 68-75. https://doi.org/10.11648/j.crj.20150304.12

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ACS Style

Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas’ud. The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous. Cancer Res. J. 2015, 3(4), 68-75. doi: 10.11648/j.crj.20150304.12

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AMA Style

Imanuel Berly Delvis Kapelle, Tun Tedja Irawadi, Meika Syahbana Rusli, Djumali Mangunwidjaja, Zainal Alim Mas’ud. The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous. Cancer Res J. 2015;3(4):68-75. doi: 10.11648/j.crj.20150304.12

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@article{10.11648/j.crj.20150304.12,
  author = {Imanuel Berly Delvis Kapelle and Tun Tedja Irawadi and Meika Syahbana Rusli and Djumali Mangunwidjaja and Zainal Alim Mas’ud},
  title = {The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous},
  journal = {Cancer Research Journal},
  volume = {3},
  number = {4},
  pages = {68-75},
  doi = {10.11648/j.crj.20150304.12},
  url = {https://doi.org/10.11648/j.crj.20150304.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20150304.12},
  abstract = {Activity anticancer of curcumin analogous influenced by the structure, substituent and geometric isomeric. The purpose of this research was to determine the influence of curcumin analog synthesis methods against anti-cancer activity. The value of IC50 tested in vitro against breast cancer cells T47D uses the MTT method for samples aks (1,5-bis-benzo[1.3]dioxol-5-yl-penta-1,4-dien-3-one) with a method of the process of microwave 257,798 µg/ml better than conventional method 555,276 µg/ml. The results IC50 for samples akas (5-benzo 1.3 dioxol-5-yl-1-phenyl-penta-2,4-dien-1-one) with a method of microwave 7,247 µg/ml better than conventional method 125,300 µg/ml. Microwave method produces a product with a lower melting point and provide the results of anti-cancer activity against breast cancer cells T47D.},
 year = {2015}
}

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TY  - JOUR
T1  - The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous
AU  - Imanuel Berly Delvis Kapelle
AU  - Tun Tedja Irawadi
AU  - Meika Syahbana Rusli
AU  - Djumali Mangunwidjaja
AU  - Zainal Alim Mas’ud
Y1  - 2015/07/04
PY  - 2015
N1  - https://doi.org/10.11648/j.crj.20150304.12
DO  - 10.11648/j.crj.20150304.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 68
EP  - 75
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20150304.12
AB  - Activity anticancer of curcumin analogous influenced by the structure, substituent and geometric isomeric. The purpose of this research was to determine the influence of curcumin analog synthesis methods against anti-cancer activity. The value of IC50 tested in vitro against breast cancer cells T47D uses the MTT method for samples aks (1,5-bis-benzo[1.3]dioxol-5-yl-penta-1,4-dien-3-one) with a method of the process of microwave 257,798 µg/ml better than conventional method 555,276 µg/ml. The results IC50 for samples akas (5-benzo 1.3 dioxol-5-yl-1-phenyl-penta-2,4-dien-1-one) with a method of microwave 7,247 µg/ml better than conventional method 125,300 µg/ml. Microwave method produces a product with a lower melting point and provide the results of anti-cancer activity against breast cancer cells T47D.
VL  - 3
IS  - 4
ER  -

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Author Information

Imanuel Berly Delvis Kapelle

Chemistry Department, Mathematic and Natural Science Faculty, Pattimura University, Maluku, Indonesia; Agricultural Industry Technology Department, Agriculture Technology Faculty, Bogor Agricultural Institute, Bogor, Indonesia
Tun Tedja Irawadi

Chemistry Department, Mathematic and Natural Science Faculty, Bogor Agricultural Institute, Bogor, Indonesia
Meika Syahbana Rusli

Agricultural Industry Technology Department, Agriculture Technology Faculty, Bogor Agricultural Institute, Bogor, Indonesia
Djumali Mangunwidjaja

Agricultural Industry Technology Department, Agriculture Technology Faculty, Bogor Agricultural Institute, Bogor, Indonesia
Zainal Alim Mas’ud

Chemistry Department, Mathematic and Natural Science Faculty, Bogor Agricultural Institute, Bogor, Indonesia

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APA Style

Imanuel Berly Delvis Kapelle, Tun Tedja Irawadi, Meika Syahbana Rusli, Djumali Mangunwidjaja, Zainal Alim Mas’ud. (2015). The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous. Cancer Research Journal, 3(4), 68-75. https://doi.org/10.11648/j.crj.20150304.12

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ACS Style

Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas’ud. The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous. Cancer Res. J. 2015, 3(4), 68-75. doi: 10.11648/j.crj.20150304.12

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AMA Style

Imanuel Berly Delvis Kapelle, Tun Tedja Irawadi, Meika Syahbana Rusli, Djumali Mangunwidjaja, Zainal Alim Mas’ud. The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous. Cancer Res J. 2015;3(4):68-75. doi: 10.11648/j.crj.20150304.12

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@article{10.11648/j.crj.20150304.12,
  author = {Imanuel Berly Delvis Kapelle and Tun Tedja Irawadi and Meika Syahbana Rusli and Djumali Mangunwidjaja and Zainal Alim Mas’ud},
  title = {The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous},
  journal = {Cancer Research Journal},
  volume = {3},
  number = {4},
  pages = {68-75},
  doi = {10.11648/j.crj.20150304.12},
  url = {https://doi.org/10.11648/j.crj.20150304.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20150304.12},
  abstract = {Activity anticancer of curcumin analogous influenced by the structure, substituent and geometric isomeric. The purpose of this research was to determine the influence of curcumin analog synthesis methods against anti-cancer activity. The value of IC50 tested in vitro against breast cancer cells T47D uses the MTT method for samples aks (1,5-bis-benzo[1.3]dioxol-5-yl-penta-1,4-dien-3-one) with a method of the process of microwave 257,798 µg/ml better than conventional method 555,276 µg/ml. The results IC50 for samples akas (5-benzo 1.3 dioxol-5-yl-1-phenyl-penta-2,4-dien-1-one) with a method of microwave 7,247 µg/ml better than conventional method 125,300 µg/ml. Microwave method produces a product with a lower melting point and provide the results of anti-cancer activity against breast cancer cells T47D.},
 year = {2015}
}

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TY  - JOUR
T1  - The Influence of Synthesis Methods Against Anti-Cancer Activity of Curcumin Analogous
AU  - Imanuel Berly Delvis Kapelle
AU  - Tun Tedja Irawadi
AU  - Meika Syahbana Rusli
AU  - Djumali Mangunwidjaja
AU  - Zainal Alim Mas’ud
Y1  - 2015/07/04
PY  - 2015
N1  - https://doi.org/10.11648/j.crj.20150304.12
DO  - 10.11648/j.crj.20150304.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 68
EP  - 75
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20150304.12
AB  - Activity anticancer of curcumin analogous influenced by the structure, substituent and geometric isomeric. The purpose of this research was to determine the influence of curcumin analog synthesis methods against anti-cancer activity. The value of IC50 tested in vitro against breast cancer cells T47D uses the MTT method for samples aks (1,5-bis-benzo[1.3]dioxol-5-yl-penta-1,4-dien-3-one) with a method of the process of microwave 257,798 µg/ml better than conventional method 555,276 µg/ml. The results IC50 for samples akas (5-benzo 1.3 dioxol-5-yl-1-phenyl-penta-2,4-dien-1-one) with a method of microwave 7,247 µg/ml better than conventional method 125,300 µg/ml. Microwave method produces a product with a lower melting point and provide the results of anti-cancer activity against breast cancer cells T47D.
VL  - 3
IS  - 4
ER  -

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