The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases

Alexei N. Shoutko; Lyudmila P. Ekimova

doi:doi:10.11648/j.crj.20140206.14

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The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases

Alexei N. Shoutko, Lyudmila P. Ekimova

Published in Cancer Research Journal (Volume 2, Issue 6)

Received: 8 November 2014 Accepted: 28 November 2014 Published: 2 December 2014

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Abstract

Deep myelosuppression, an officially sanctioned effect of non-selective cytotoxic cancer therapy, would be expected to be incompatible with mounting of a powerful host defense against spontaneous malignancy. To explore this theoretical difficulty, we used middle age as a natural model of a temporary decline in lymphocytopoiesis, caused by physiological thymus involution. The impact of middle age on the levels of death from nonmalignant and malignant diseases was analyzed retrospectively, using population health data from Europe (the European Network of Economic Policy Research Institutes, 1995); the UK (Statistics Team at the Cancer Research UK, and the Office for National Statistics cancer survival rates for 2007-2010), and the USA (National Center for Health Statistics, 1987-2007; National Vital Statistics System, 1999-2010; National Cancer Institute's Surveillance, Epidemiology, and End Results [SEER], 1992-2010). The rate of death and survival used to check whether the vectors of middle age-specific changes of these parameters are opposite or coincident in cancer patients and those with certain non-malignant somatic diseases. According the temporary trend on a middle- age portion of plot, the curves were graded negative or positive (+ = viability is not change or goes up; - = viability goes down).Comparisons of aggregate data showed that middle age exerted opposite effects on the health of those with cancer and non-malignant diseases. In middle age, serious health conditions, such as some cancers, are easier to treat, but the overall quality of life is reduced by various morbidities, especially infections. The comparing of the impact of middle age on the viability of patients with nonmalignant and malignant diseases in alternative terms of immunity or morphogenesis leads to recognition of trophic contribution of thymus into tumor development. By analogy, we assume that use of cytotoxic therapy can exert indirect benefit, thus compromising hemato- lymphocytopoiesis.

Published in	Cancer Research Journal (Volume 2, Issue 6)
DOI	10.11648/j.crj.20140206.14
Page(s)	114-120
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Death Rates, Malignancy, Middle Age, Mielopoiesis, Populations

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Alexei N. Shoutko, Lyudmila P. Ekimova. (2014). The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases. Cancer Research Journal, 2(6), 114-120. https://doi.org/10.11648/j.crj.20140206.14

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Alexei N. Shoutko; Lyudmila P. Ekimova. The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases. Cancer Res. J. 2014, 2(6), 114-120. doi: 10.11648/j.crj.20140206.14

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AMA Style

Alexei N. Shoutko, Lyudmila P. Ekimova. The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases. Cancer Res J. 2014;2(6):114-120. doi: 10.11648/j.crj.20140206.14

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@article{10.11648/j.crj.20140206.14,
  author = {Alexei N. Shoutko and Lyudmila P. Ekimova},
  title = {The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {6},
  pages = {114-120},
  doi = {10.11648/j.crj.20140206.14},
  url = {https://doi.org/10.11648/j.crj.20140206.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20140206.14},
  abstract = {Deep myelosuppression, an officially sanctioned effect of non-selective cytotoxic cancer therapy, would be expected to be incompatible with mounting of a powerful host defense against spontaneous malignancy. To explore this theoretical difficulty, we used middle age as a natural model of a temporary decline in lymphocytopoiesis, caused by physiological thymus involution. The impact of middle age on the levels of death from nonmalignant and malignant diseases was analyzed retrospectively, using population health data from Europe (the European Network of Economic Policy Research Institutes, 1995); the UK (Statistics Team at the Cancer Research UK, and the Office for National Statistics cancer survival rates for 2007-2010), and the USA (National Center for Health Statistics, 1987-2007; National Vital Statistics System, 1999-2010; National Cancer Institute's Surveillance, Epidemiology, and End Results [SEER], 1992-2010). The rate of death and survival used to check whether the vectors of middle age-specific changes of these parameters are opposite or coincident in cancer patients and those with certain non-malignant somatic diseases. According the temporary trend on a middle- age portion of plot, the curves were graded negative or positive (+ = viability is not change or goes up; - = viability goes down).Comparisons of aggregate data showed that middle age exerted opposite effects on the health of those with cancer and non-malignant diseases. In middle age, serious health conditions, such as some cancers, are easier to treat, but the overall quality of life is reduced by various morbidities, especially infections. The comparing of the impact of middle age on the viability of patients with nonmalignant and malignant diseases in alternative terms of immunity or morphogenesis leads to recognition of trophic contribution of thymus into tumor development. By analogy, we assume that use of cytotoxic therapy can exert indirect benefit, thus compromising hemato- lymphocytopoiesis.},
 year = {2014}
}

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TY  - JOUR
T1  - The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases
AU  - Alexei N. Shoutko
AU  - Lyudmila P. Ekimova
Y1  - 2014/12/02
PY  - 2014
N1  - https://doi.org/10.11648/j.crj.20140206.14
DO  - 10.11648/j.crj.20140206.14
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 114
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PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20140206.14
AB  - Deep myelosuppression, an officially sanctioned effect of non-selective cytotoxic cancer therapy, would be expected to be incompatible with mounting of a powerful host defense against spontaneous malignancy. To explore this theoretical difficulty, we used middle age as a natural model of a temporary decline in lymphocytopoiesis, caused by physiological thymus involution. The impact of middle age on the levels of death from nonmalignant and malignant diseases was analyzed retrospectively, using population health data from Europe (the European Network of Economic Policy Research Institutes, 1995); the UK (Statistics Team at the Cancer Research UK, and the Office for National Statistics cancer survival rates for 2007-2010), and the USA (National Center for Health Statistics, 1987-2007; National Vital Statistics System, 1999-2010; National Cancer Institute's Surveillance, Epidemiology, and End Results [SEER], 1992-2010). The rate of death and survival used to check whether the vectors of middle age-specific changes of these parameters are opposite or coincident in cancer patients and those with certain non-malignant somatic diseases. According the temporary trend on a middle- age portion of plot, the curves were graded negative or positive (+ = viability is not change or goes up; - = viability goes down).Comparisons of aggregate data showed that middle age exerted opposite effects on the health of those with cancer and non-malignant diseases. In middle age, serious health conditions, such as some cancers, are easier to treat, but the overall quality of life is reduced by various morbidities, especially infections. The comparing of the impact of middle age on the viability of patients with nonmalignant and malignant diseases in alternative terms of immunity or morphogenesis leads to recognition of trophic contribution of thymus into tumor development. By analogy, we assume that use of cytotoxic therapy can exert indirect benefit, thus compromising hemato- lymphocytopoiesis.
VL  - 2
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Author Information

Alexei N. Shoutko

Medical Radiobiology Department, Federal Scientific Centre for Radiology and Surgical Technologies, Saint-Petersburg, Russian Federation
Lyudmila P. Ekimova

Medical Radiobiology Department, Federal Scientific Centre for Radiology and Surgical Technologies, Saint-Petersburg, Russian Federation

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Alexei N. Shoutko, Lyudmila P. Ekimova. (2014). The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases. Cancer Research Journal, 2(6), 114-120. https://doi.org/10.11648/j.crj.20140206.14

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ACS Style

Alexei N. Shoutko; Lyudmila P. Ekimova. The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases. Cancer Res. J. 2014, 2(6), 114-120. doi: 10.11648/j.crj.20140206.14

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AMA Style

Alexei N. Shoutko, Lyudmila P. Ekimova. The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases. Cancer Res J. 2014;2(6):114-120. doi: 10.11648/j.crj.20140206.14

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@article{10.11648/j.crj.20140206.14,
  author = {Alexei N. Shoutko and Lyudmila P. Ekimova},
  title = {The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {6},
  pages = {114-120},
  doi = {10.11648/j.crj.20140206.14},
  url = {https://doi.org/10.11648/j.crj.20140206.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20140206.14},
  abstract = {Deep myelosuppression, an officially sanctioned effect of non-selective cytotoxic cancer therapy, would be expected to be incompatible with mounting of a powerful host defense against spontaneous malignancy. To explore this theoretical difficulty, we used middle age as a natural model of a temporary decline in lymphocytopoiesis, caused by physiological thymus involution. The impact of middle age on the levels of death from nonmalignant and malignant diseases was analyzed retrospectively, using population health data from Europe (the European Network of Economic Policy Research Institutes, 1995); the UK (Statistics Team at the Cancer Research UK, and the Office for National Statistics cancer survival rates for 2007-2010), and the USA (National Center for Health Statistics, 1987-2007; National Vital Statistics System, 1999-2010; National Cancer Institute's Surveillance, Epidemiology, and End Results [SEER], 1992-2010). The rate of death and survival used to check whether the vectors of middle age-specific changes of these parameters are opposite or coincident in cancer patients and those with certain non-malignant somatic diseases. According the temporary trend on a middle- age portion of plot, the curves were graded negative or positive (+ = viability is not change or goes up; - = viability goes down).Comparisons of aggregate data showed that middle age exerted opposite effects on the health of those with cancer and non-malignant diseases. In middle age, serious health conditions, such as some cancers, are easier to treat, but the overall quality of life is reduced by various morbidities, especially infections. The comparing of the impact of middle age on the viability of patients with nonmalignant and malignant diseases in alternative terms of immunity or morphogenesis leads to recognition of trophic contribution of thymus into tumor development. By analogy, we assume that use of cytotoxic therapy can exert indirect benefit, thus compromising hemato- lymphocytopoiesis.},
 year = {2014}
}

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TY  - JOUR
T1  - The Impact of Middle Age on the Viability of Patients with Nonmalignant and Malignant Diseases
AU  - Alexei N. Shoutko
AU  - Lyudmila P. Ekimova
Y1  - 2014/12/02
PY  - 2014
N1  - https://doi.org/10.11648/j.crj.20140206.14
DO  - 10.11648/j.crj.20140206.14
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 114
EP  - 120
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20140206.14
AB  - Deep myelosuppression, an officially sanctioned effect of non-selective cytotoxic cancer therapy, would be expected to be incompatible with mounting of a powerful host defense against spontaneous malignancy. To explore this theoretical difficulty, we used middle age as a natural model of a temporary decline in lymphocytopoiesis, caused by physiological thymus involution. The impact of middle age on the levels of death from nonmalignant and malignant diseases was analyzed retrospectively, using population health data from Europe (the European Network of Economic Policy Research Institutes, 1995); the UK (Statistics Team at the Cancer Research UK, and the Office for National Statistics cancer survival rates for 2007-2010), and the USA (National Center for Health Statistics, 1987-2007; National Vital Statistics System, 1999-2010; National Cancer Institute's Surveillance, Epidemiology, and End Results [SEER], 1992-2010). The rate of death and survival used to check whether the vectors of middle age-specific changes of these parameters are opposite or coincident in cancer patients and those with certain non-malignant somatic diseases. According the temporary trend on a middle- age portion of plot, the curves were graded negative or positive (+ = viability is not change or goes up; - = viability goes down).Comparisons of aggregate data showed that middle age exerted opposite effects on the health of those with cancer and non-malignant diseases. In middle age, serious health conditions, such as some cancers, are easier to treat, but the overall quality of life is reduced by various morbidities, especially infections. The comparing of the impact of middle age on the viability of patients with nonmalignant and malignant diseases in alternative terms of immunity or morphogenesis leads to recognition of trophic contribution of thymus into tumor development. By analogy, we assume that use of cytotoxic therapy can exert indirect benefit, thus compromising hemato- lymphocytopoiesis.
VL  - 2
IS  - 6
ER  -

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