Cancer Research Journal

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Chemoimmunotherapy Resistant Follicular Lymphoma – A Single Institutional Study

Received: 10 September 2014    Accepted: 17 September 2014    Published: 30 September 2014
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Abstract

Follicular lymphoma (FL) is the most common indolent form of non Hodgkin lymphoma and characterized by initial response to treatment with inevitable relapse. Rituximab, is an anti CD20 monoclonal antibody, plays an important role in combination chemoimmunotherapy in treatment of symptomatic follicular lymphoma. Though rituximab is helpful in reducing the tumor burden in patients of follicular lymphoma, a significant proportion of patients were found to have resistance to rituximab and eventually progressed to high grade lymphoma. In this study we evaluated chemoimmunotherapy (CIR) resistant patients to know the incidence, predictive factors associated with CIR resistance and prognosis. This is a retrospective study, included 49 patients of follicular lymphoma, of these 12 (24.5%) demonstrated CIR resistance. On univariate analysis, high LDH values, advanced stage and high FLIPI score may predict the resistance of CIR therapy in initial stage of therapy. Overall, 7 patients (58.3%) progressed to high grade lymphoma (biopsy proven) and 2 (16.6%) died of disease progression in CIR resistant patients. Progressive free survival significantly reduced in CIR resistant patients (26 months) than CIR responders.

DOI 10.11648/j.crj.20140205.13
Published in Cancer Research Journal (Volume 2, Issue 5, September 2014)
Page(s) 93-97
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chemoimmunotherapy Resistance, Follicular Lymphoma, FLIPI Score, Lactate Dehydrogenase, Advance Stage, Progression

References
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[4] van Oers MH, Klasa R, Marcus RE et al. Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial. Blood 2006;108:3295-3301.
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Author Information
  • Department of Pathology, Nizam`s Institute of Medical Sciences, Hyderabad, India

  • Department of Pathology, Nizam`s Institute of Medical Sciences, Hyderabad, India

  • Department of Pathology, Nizam`s Institute of Medical Sciences, Hyderabad, India

  • Department of Pathology, Nizam`s Institute of Medical Sciences, Hyderabad, India

  • Department of Pathology, Osmania Medical College, Hyderabad, India

  • Department of Pathology, Nizam`s Institute of Medical Sciences, Hyderabad, India

  • Department of Medical Oncology, Nizam`s Institute of Medical Sciences, Hyderabad, India

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    Sampath Kumar-Kandala Jeevan, Roshni Paul-Tara, Shantiveer Uppin, Megha Uppin, Kavitha Bali, et al. (2014). Chemoimmunotherapy Resistant Follicular Lymphoma – A Single Institutional Study. Cancer Research Journal, 2(5), 93-97. https://doi.org/10.11648/j.crj.20140205.13

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    ACS Style

    Sampath Kumar-Kandala Jeevan; Roshni Paul-Tara; Shantiveer Uppin; Megha Uppin; Kavitha Bali, et al. Chemoimmunotherapy Resistant Follicular Lymphoma – A Single Institutional Study. Cancer Res. J. 2014, 2(5), 93-97. doi: 10.11648/j.crj.20140205.13

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    AMA Style

    Sampath Kumar-Kandala Jeevan, Roshni Paul-Tara, Shantiveer Uppin, Megha Uppin, Kavitha Bali, et al. Chemoimmunotherapy Resistant Follicular Lymphoma – A Single Institutional Study. Cancer Res J. 2014;2(5):93-97. doi: 10.11648/j.crj.20140205.13

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  • @article{10.11648/j.crj.20140205.13,
      author = {Sampath Kumar-Kandala Jeevan and Roshni Paul-Tara and Shantiveer Uppin and Megha Uppin and Kavitha Bali and Sundaram- Challa and Raghunadha Rao},
      title = {Chemoimmunotherapy Resistant Follicular Lymphoma – A Single Institutional Study},
      journal = {Cancer Research Journal},
      volume = {2},
      number = {5},
      pages = {93-97},
      doi = {10.11648/j.crj.20140205.13},
      url = {https://doi.org/10.11648/j.crj.20140205.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.crj.20140205.13},
      abstract = {Follicular lymphoma (FL) is the most common indolent form of non Hodgkin lymphoma and characterized by initial response to treatment with inevitable relapse. Rituximab, is an anti CD20 monoclonal antibody, plays an important role in combination chemoimmunotherapy in treatment of symptomatic follicular lymphoma. Though rituximab is helpful in reducing the tumor burden in patients of follicular lymphoma, a significant proportion of patients were found to have resistance to rituximab and eventually progressed to high grade lymphoma. In this study we evaluated chemoimmunotherapy (CIR) resistant patients to know the incidence, predictive factors associated with CIR resistance and prognosis. This is a retrospective study, included 49 patients of follicular lymphoma, of these 12 (24.5%) demonstrated CIR resistance. On univariate analysis, high LDH values, advanced stage and high FLIPI score may predict the resistance of CIR therapy in initial stage of therapy. Overall, 7 patients (58.3%) progressed to high grade lymphoma (biopsy proven) and 2 (16.6%) died of disease progression in CIR resistant patients. Progressive free survival significantly reduced in CIR resistant patients (26 months) than CIR responders.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Chemoimmunotherapy Resistant Follicular Lymphoma – A Single Institutional Study
    AU  - Sampath Kumar-Kandala Jeevan
    AU  - Roshni Paul-Tara
    AU  - Shantiveer Uppin
    AU  - Megha Uppin
    AU  - Kavitha Bali
    AU  - Sundaram- Challa
    AU  - Raghunadha Rao
    Y1  - 2014/09/30
    PY  - 2014
    N1  - https://doi.org/10.11648/j.crj.20140205.13
    DO  - 10.11648/j.crj.20140205.13
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 93
    EP  - 97
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20140205.13
    AB  - Follicular lymphoma (FL) is the most common indolent form of non Hodgkin lymphoma and characterized by initial response to treatment with inevitable relapse. Rituximab, is an anti CD20 monoclonal antibody, plays an important role in combination chemoimmunotherapy in treatment of symptomatic follicular lymphoma. Though rituximab is helpful in reducing the tumor burden in patients of follicular lymphoma, a significant proportion of patients were found to have resistance to rituximab and eventually progressed to high grade lymphoma. In this study we evaluated chemoimmunotherapy (CIR) resistant patients to know the incidence, predictive factors associated with CIR resistance and prognosis. This is a retrospective study, included 49 patients of follicular lymphoma, of these 12 (24.5%) demonstrated CIR resistance. On univariate analysis, high LDH values, advanced stage and high FLIPI score may predict the resistance of CIR therapy in initial stage of therapy. Overall, 7 patients (58.3%) progressed to high grade lymphoma (biopsy proven) and 2 (16.6%) died of disease progression in CIR resistant patients. Progressive free survival significantly reduced in CIR resistant patients (26 months) than CIR responders.
    VL  - 2
    IS  - 5
    ER  - 

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