Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells
Cancer Research Journal
Volume 2, Issue 3, May 2014, Pages: 42-46
Received: Apr. 17, 2014; Accepted: May 23, 2014; Published: Jun. 10, 2014
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Authors
Xuejun Zhan, Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
Daze Xie, Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
Yingyin Hu, Cancer Research Laboratory, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
Ge Dai, Department of Nuclear Medicine, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
Yanping Xu, Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China
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Abstract
Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P<0.05~P<0.01). There was no significant difference in the ATP concentration between MKM45 cells that were treated with the three Chinese medicinal materials and those exposed to 5-Fu (P>0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.
Keywords
Gastric Carcinoma Cells, Anti- Cancer Chinese Medicinal Materials, ATP Concentration
To cite this article
Xuejun Zhan, Daze Xie, Yingyin Hu, Ge Dai, Yanping Xu, Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells, Cancer Research Journal. Vol. 2, No. 3, 2014, pp. 42-46. doi: 10.11648/j.crj.20140203.11
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