International Journal of Medical Imaging

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The Problem of Nephropathy Induced by Endocavitary Administration of Iodine-Containing X-ray Contrast Agents

Received: 16 June 2016    Accepted: 05 July 2016    Published: 18 July 2016
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Abstract

It is known that there is a high risk of progression of side effects in kidneys, so-called nephropathy induced with X-ray contrast agents, at applying of water-soluble X-ray contrast agents in medical practice. New water-insoluble compounds of orthotantalates of rare-earth elements are offered as new X-ray contrast agents for endocavitary administration. The achieved results have shown the absence of general toxic effect on bodies of animals, high X-ray contrast properties in vitro and in vivo experiments. The investigations were performed on white nondescript mice, rats Wistar subtype and Chinchilla rabbits.

DOI 10.11648/j.ijmi.20160403.12
Published in International Journal of Medical Imaging (Volume 4, Issue 3, May 2016)
Page(s) 17-22
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

X-ray Contract Agents, Nephropathy Induced with X-ray Contrast Agents, Orthotantalates of Rare-Earth Elements

References
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[2] Shimanovskii N. L. Contrast agents. Efficient application guide. Moscow: GEOTAR–Media. 2009. 463 p. [in Russian].
[3] John A. K. Renal insufficiency: gadopentetate dimeglumine as a radiographic contrast agent during peripheral vascular interventional procedures / A. K. John, C. G. Stuart, C. W. Arthur // Radiology. 1996. Vol. 198, pp. 579 – 581.
[4] Gomes A. S. Acute renal dysfunction in high–risk patients after angiography: comparison of ionic contrast media / A. S. Gomes, I. F. Lois, I. D. Baxer // Radiology. 1989. Vol. 121, No. 14, pp. 410 – 415.
[5] Sergeyev P. V., Sviridov N. K., Shimanovskii N. L. X-ray contrast agents. Moscow: Meditsina. 1993. 307 p. [in Russian].
[6] Strekalov I. M. A new X-ray contrast agent – lanthanum orthotantalate and possibilities of its application in abdominal surgery (experimental study): candidate of science (medicine) thesis / I. M. Strekalov / Ekaterinburg. 2007, pp. 84 – 87. [in Russian].
[7] Velmas T. / Gd–DTPA as an alternative contrast agent in conventional and interventional and radiology / T. Velmas T. Markkola // Acta Radiol. 1998. Vol. 39, pp. 223 – 226.
[8] Zuev M. G., Larionov L. P. Tantalum X-ray contrast agents (Solid-State Chemistry for Medicine Series). Ekaterinburg: Ural. Otd., Ross. Akad. Nauk, 2002. ISBN 5-7691-1282-4. [in Russian]. 155 p.
[9] New Materials for Medicine / Collective of authors, M. G. Zuev and L. P. Larionov, Eds., Eekaterinburg: Ural. Otd., Ross. Akad. Nauk, 2006. ISBN 5-7691-1718-4. [in Russian]. 166 p.
[10] Zhuravleva E. Yu. Tantalum X-ray Contrast Media (Solid-State Chemistry for Medicine Series), by M. G. Zuev and L. P. Larionov, Eekaterinburg: Ural. Otd., Ross. Akad. Nauk, 2002 // Inorganic Materials, Vol. 40, No. 6, 2004, pp. 671 – 672.
[11] Zhuravleva E. Yu. New Materials for Medicine, M. G. Zuev and L. P. Larionov, Eds., Eekaterinburg: Ural. Otd., Ross. Akad. Nauk, 2006 // Inorganic Materials, 2007, Vol. 43, No. 9, p. 1034.
[12] Zuev M. G. and Larionov L. P. "Tantalic Radio-Opaque Drugs. Preclinical Studies" Monography. Lambert Academic Publishing, 2012. 250 p. [in Russian].
[13] Strekalov I. M., Larionov L. P., Zuyev M. G. // Vestnik rentgenologii i radiologii. 2007 NO 1, pp. 45 – 54.
Author Information
  • Central City Clinical Hospital No. 1, Ekaterinburg, Russia

  • Department of Pharmacology and Clinical Pharmacology, Faculty of Pharmacy, Ural State Medical University, Ekaterinburg, Russia

  • Oxide Systems Laboratory, Institute of Solid State Chemistry, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia

  • Experimental Physics Department, Physico-Technical Institute, Ural Federal University Named After the First President of Russia B. N. Yeltsin, Ekaterinburg, Russia

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    Iliya Mikhailovich Strekalov, Leonid Petrovich Larionov, Мikhail Georgievich Zuev, Elena Yuryevna Zhuravleva. (2016). The Problem of Nephropathy Induced by Endocavitary Administration of Iodine-Containing X-ray Contrast Agents. International Journal of Medical Imaging, 4(3), 17-22. https://doi.org/10.11648/j.ijmi.20160403.12

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    Iliya Mikhailovich Strekalov; Leonid Petrovich Larionov; Мikhail Georgievich Zuev; Elena Yuryevna Zhuravleva. The Problem of Nephropathy Induced by Endocavitary Administration of Iodine-Containing X-ray Contrast Agents. Int. J. Med. Imaging 2016, 4(3), 17-22. doi: 10.11648/j.ijmi.20160403.12

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    AMA Style

    Iliya Mikhailovich Strekalov, Leonid Petrovich Larionov, Мikhail Georgievich Zuev, Elena Yuryevna Zhuravleva. The Problem of Nephropathy Induced by Endocavitary Administration of Iodine-Containing X-ray Contrast Agents. Int J Med Imaging. 2016;4(3):17-22. doi: 10.11648/j.ijmi.20160403.12

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  • @article{10.11648/j.ijmi.20160403.12,
      author = {Iliya Mikhailovich Strekalov and Leonid Petrovich Larionov and Мikhail Georgievich Zuev and Elena Yuryevna Zhuravleva},
      title = {The Problem of Nephropathy Induced by Endocavitary Administration of Iodine-Containing X-ray Contrast Agents},
      journal = {International Journal of Medical Imaging},
      volume = {4},
      number = {3},
      pages = {17-22},
      doi = {10.11648/j.ijmi.20160403.12},
      url = {https://doi.org/10.11648/j.ijmi.20160403.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijmi.20160403.12},
      abstract = {It is known that there is a high risk of progression of side effects in kidneys, so-called nephropathy induced with X-ray contrast agents, at applying of water-soluble X-ray contrast agents in medical practice. New water-insoluble compounds of orthotantalates of rare-earth elements are offered as new X-ray contrast agents for endocavitary administration. The achieved results have shown the absence of general toxic effect on bodies of animals, high X-ray contrast properties in vitro and in vivo experiments. The investigations were performed on white nondescript mice, rats Wistar subtype and Chinchilla rabbits.},
     year = {2016}
    }
    

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    AU  - Iliya Mikhailovich Strekalov
    AU  - Leonid Petrovich Larionov
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    AB  - It is known that there is a high risk of progression of side effects in kidneys, so-called nephropathy induced with X-ray contrast agents, at applying of water-soluble X-ray contrast agents in medical practice. New water-insoluble compounds of orthotantalates of rare-earth elements are offered as new X-ray contrast agents for endocavitary administration. The achieved results have shown the absence of general toxic effect on bodies of animals, high X-ray contrast properties in vitro and in vivo experiments. The investigations were performed on white nondescript mice, rats Wistar subtype and Chinchilla rabbits.
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