A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report

Muhammad Yunus Amran; Hasmawaty Basir; Andi Kurnia Bintang; Muhammad Akbar

doi:doi:10.11648/j.ijmi.20140201.11

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A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report

Muhammad Yunus Amran, Hasmawaty Basir, Andi Kurnia Bintang, Muhammad Akbar

Published in International Journal of Medical Imaging (Volume 2, Issue 1)

Received: 22 October 2013 Accepted: Published: 10 January 2014

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Abstract

Haemangioblastoma, a benign vascular tumor derived from the capillary of endothelial cells, is an inherited disorder due to an autosomal dominant trait. The prevalence rates accounted for 1% to 2.5% of all intracranial tumors and 2% to 3% of all intramedullary spinal cord tumors. We report the infrequent case of a robust allegation of von Hippel-Lindau (VHL) associated haemangioblastoma in the central nervous system of a man. A 20 years old male presented to the hospital with the chief complaint of progressive chronic cephalgia three months prior to hospitalization. He complained also of blurred vision on neurologic examination; there is papilla edema with suspicion of retinal edema. Radiological examination result suggested a cerebellar haemangioblastoma dextra with noncommunicating hydrocephalus. After the first operation (installation of VP shunting) and subsequent operation (excision of the tumor), the pathological anatomy results revealed a cavernous angioma.

Published in	International Journal of Medical Imaging (Volume 2, Issue 1)
DOI	10.11648/j.ijmi.20140201.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Haemangioblastoma, CNS, CT-Scan, Von Hippel-Lindau Diseases

References

[1]	James TJ, Yung WKA. Hemangioblastoma. In : Goetz CG, ed. Text book of clinical neurology. 2nd ed. Philadelphia : Saunders, 2003; 1037.
[2]	Dahret W. Hemangioblastoma of CNS. In : Grayson TH, ed. Radiology review manual. 2nd ed. Baltimore : Williams & Wilkins, 1993: 180-1.
[3]	Gilroy J. Hemangioblastoma. In : Basic neurology. 3rd ed. New York : McGraw-Hill, 2000: 416-7.
[4]	Lindau A. Studien über Kleinhirnzysten. Bau, Pathogenese und Beziehungen zur Angiomatosis retinae. Acta Pathol Microbiol Scand 1926; S1: 1–128.
[5]	von Hippel E. Ueber eine sehr seltene Erkrankung der Netzhaut. Klinische Beobachtungen. A von Graefe’s Arch Ophthalmol 1904; 59: 83–106.
[6]	Vates GE, Auguste KI, Berger MS. Hemangioblastomas. In : Berger MS, Prades MD, eds. Textbook of neuro-oncology. 1st ed. Philadelphia : Elsevier Saunders, 2005: 294-300.
[7]	Solomon RA, Spellman JP, Mohr JP. Hemangioblastoma. In : Rowland LP, ed. Merritt’s neurology. 10th ed. Philadelphia : Lippincott Williams & Wilkins, 2000; 374-5
[8]	Neumann HPH, Eggert HR, Weigel K, et al. Hemangioblastomas of the central nervous system. A 10 year study with special reference to von Hippel–Lindau syndrome. J Neurosurg 1989; 70:24–30.
[9]	Bohling T, Plate KH, Haltia M, et al: von Hippel-Lindau disease and capillary haemangioblastoma. In Cavanee WK (ed): World Health Organization Classification of Tumours: Pathology and Genetics of Tumors of the Nervous System. Lyon, France, IARC Press, 2000.
[10]	Frantzen C, Links TP, Giles RH. Von Hippel-Lindau Disease. 2000 May 17 [Updated 2012 Jun 21]. In: Pagon RA, Bird TD, Dolan CR, et al., editors. GeneReviews™ [Internet]. Seattle (WA): University of Washington, Seattle;1993-.Available from: http://www.ncbi.nlm.nih.gov/books/NBK1463/
[11]	Resche F, Moisan JP, Mantoura J, de Kersaint-Gilly A, Andre MJ, Perrin-Resche I et al. Haemangioblastoma, haemangioblastomatosis, and von Hippel-Lindau disease. Adv Tech Stand Neurosurg 1993; 20:197- 304: 197-304.
[12]	Friedrich CA. Von Hippel-Lindau syndrome. A pleomorphic condition. Cancer 1999; 86(11 Suppl):2478-2482.
[13]	Richard S, Campello C, Taillandier L, Parker F, Resche F. Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group. J Intern Med 1998; 243(6):547-553.
[14]	Solomon RA, Spellman JP, Mohr JP. Hemangioblastoma. In : Rowland LP, ed. Merritt’s neurology. 10th ed. Philadelphia : Lippincott Williams & Wilkins, 2000; 374-5.
[15]	Victor M, Ropper AH. Hemangioblastoma of the cerebellum. In : Adams and Victor’s principles of neurology. 7th ed. New York : McGraw-Hill, 2001; 705-6.
[16]	Vates GE, Auguste KI, Berger MS. Hemangioblastomas. In : Berger MS, Prades MD, eds. Textbook of neuro-oncology. 1st ed. Philadelphia: Elsevier Saunders, 2005: 294-300.
[17]	Haughton VM, Daniels DL. Hemangioblastoma. In: William AL, Haughton VM, eds. Cranial computed tomography. ST Louis: The CV Mosby Company, 1985: 382-6.

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APA Style

Muhammad Yunus Amran, Hasmawaty Basir, Andi Kurnia Bintang, Muhammad Akbar. (2014). A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report. International Journal of Medical Imaging, 2(1), 1-4. https://doi.org/10.11648/j.ijmi.20140201.11

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ACS Style

Muhammad Yunus Amran; Hasmawaty Basir; Andi Kurnia Bintang; Muhammad Akbar. A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report. Int. J. Med. Imaging 2014, 2(1), 1-4. doi: 10.11648/j.ijmi.20140201.11

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AMA Style

Muhammad Yunus Amran, Hasmawaty Basir, Andi Kurnia Bintang, Muhammad Akbar. A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report. Int J Med Imaging. 2014;2(1):1-4. doi: 10.11648/j.ijmi.20140201.11

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@article{10.11648/j.ijmi.20140201.11,
  author = {Muhammad Yunus Amran and Hasmawaty Basir and Andi Kurnia Bintang and Muhammad Akbar},
  title = {A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report},
  journal = {International Journal of Medical Imaging},
  volume = {2},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijmi.20140201.11},
  url = {https://doi.org/10.11648/j.ijmi.20140201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20140201.11},
  abstract = {Haemangioblastoma, a benign vascular tumor derived from the capillary of endothelial cells, is an inherited disorder due to an autosomal dominant trait. The prevalence rates accounted for 1% to 2.5% of all intracranial tumors and 2% to 3% of all intramedullary spinal cord tumors. We report the infrequent case of a robust allegation of von Hippel-Lindau (VHL) associated haemangioblastoma in the central nervous system of a man. A 20 years old male presented to the hospital with the chief complaint of progressive chronic cephalgia three months prior to hospitalization. He complained also of blurred vision on neurologic examination; there is papilla edema with suspicion of retinal edema. Radiological examination result suggested a cerebellar haemangioblastoma dextra with noncommunicating hydrocephalus. After the first operation (installation of VP shunting) and subsequent operation (excision of the tumor), the pathological anatomy results revealed a cavernous angioma.},
 year = {2014}
}

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TY  - JOUR
T1  - A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report
AU  - Muhammad Yunus Amran
AU  - Hasmawaty Basir
AU  - Andi Kurnia Bintang
AU  - Muhammad Akbar
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DO  - 10.11648/j.ijmi.20140201.11
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
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PB  - Science Publishing Group
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AB  - Haemangioblastoma, a benign vascular tumor derived from the capillary of endothelial cells, is an inherited disorder due to an autosomal dominant trait. The prevalence rates accounted for 1% to 2.5% of all intracranial tumors and 2% to 3% of all intramedullary spinal cord tumors. We report the infrequent case of a robust allegation of von Hippel-Lindau (VHL) associated haemangioblastoma in the central nervous system of a man. A 20 years old male presented to the hospital with the chief complaint of progressive chronic cephalgia three months prior to hospitalization. He complained also of blurred vision on neurologic examination; there is papilla edema with suspicion of retinal edema. Radiological examination result suggested a cerebellar haemangioblastoma dextra with noncommunicating hydrocephalus. After the first operation (installation of VP shunting) and subsequent operation (excision of the tumor), the pathological anatomy results revealed a cavernous angioma.
VL  - 2
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Author Information

Muhammad Yunus Amran

Hasanuddin University Teaching Hospital, Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Hasmawaty Basir

Hasanuddin University Teaching Hospital, Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Andi Kurnia Bintang

Hasanuddin University Teaching Hospital, Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Muhammad Akbar

Hasanuddin University Teaching Hospital, Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia

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APA Style

Muhammad Yunus Amran, Hasmawaty Basir, Andi Kurnia Bintang, Muhammad Akbar. (2014). A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report. International Journal of Medical Imaging, 2(1), 1-4. https://doi.org/10.11648/j.ijmi.20140201.11

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ACS Style

Muhammad Yunus Amran; Hasmawaty Basir; Andi Kurnia Bintang; Muhammad Akbar. A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report. Int. J. Med. Imaging 2014, 2(1), 1-4. doi: 10.11648/j.ijmi.20140201.11

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AMA Style

Muhammad Yunus Amran, Hasmawaty Basir, Andi Kurnia Bintang, Muhammad Akbar. A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report. Int J Med Imaging. 2014;2(1):1-4. doi: 10.11648/j.ijmi.20140201.11

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@article{10.11648/j.ijmi.20140201.11,
  author = {Muhammad Yunus Amran and Hasmawaty Basir and Andi Kurnia Bintang and Muhammad Akbar},
  title = {A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report},
  journal = {International Journal of Medical Imaging},
  volume = {2},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijmi.20140201.11},
  url = {https://doi.org/10.11648/j.ijmi.20140201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20140201.11},
  abstract = {Haemangioblastoma, a benign vascular tumor derived from the capillary of endothelial cells, is an inherited disorder due to an autosomal dominant trait. The prevalence rates accounted for 1% to 2.5% of all intracranial tumors and 2% to 3% of all intramedullary spinal cord tumors. We report the infrequent case of a robust allegation of von Hippel-Lindau (VHL) associated haemangioblastoma in the central nervous system of a man. A 20 years old male presented to the hospital with the chief complaint of progressive chronic cephalgia three months prior to hospitalization. He complained also of blurred vision on neurologic examination; there is papilla edema with suspicion of retinal edema. Radiological examination result suggested a cerebellar haemangioblastoma dextra with noncommunicating hydrocephalus. After the first operation (installation of VP shunting) and subsequent operation (excision of the tumor), the pathological anatomy results revealed a cavernous angioma.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - A Robust Allegation of Von Hippel-Lindau (VHL) Associated Hemangioblastoma in the Central Nervous System (CNS): A Case Report
AU  - Muhammad Yunus Amran
AU  - Hasmawaty Basir
AU  - Andi Kurnia Bintang
AU  - Muhammad Akbar
Y1  - 2014/01/10
PY  - 2014
N1  - https://doi.org/10.11648/j.ijmi.20140201.11
DO  - 10.11648/j.ijmi.20140201.11
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20140201.11
AB  - Haemangioblastoma, a benign vascular tumor derived from the capillary of endothelial cells, is an inherited disorder due to an autosomal dominant trait. The prevalence rates accounted for 1% to 2.5% of all intracranial tumors and 2% to 3% of all intramedullary spinal cord tumors. We report the infrequent case of a robust allegation of von Hippel-Lindau (VHL) associated haemangioblastoma in the central nervous system of a man. A 20 years old male presented to the hospital with the chief complaint of progressive chronic cephalgia three months prior to hospitalization. He complained also of blurred vision on neurologic examination; there is papilla edema with suspicion of retinal edema. Radiological examination result suggested a cerebellar haemangioblastoma dextra with noncommunicating hydrocephalus. After the first operation (installation of VP shunting) and subsequent operation (excision of the tumor), the pathological anatomy results revealed a cavernous angioma.
VL  - 2
IS  - 1
ER  -

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