Effect of Functional Fitness on Plasma Oxidation Level in Elders: Reduction of the Plasma Oxidants and Improvement of the Antioxidant Barrier
American Journal of Sports Science
Volume 6, Issue 2, June 2018, Pages: 55-64
Received: Dec. 19, 2017;
Accepted: Feb. 24, 2018;
Published: Apr. 9, 2018
Views 1548 Downloads 110
Tania Gamberi, Department of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy
Giulia Gorini, Department of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy
Tania Fiaschi, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Gabriele Morucci, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Simone Pratesi, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Lucio Fittipaldi, Department of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy
Massimo Gulisano, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Pietro Amedeo Modesti, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Alessandra Modesti, Department of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy
Francesca Magherini, Department of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy
Aging is characterized by a progressive decline in the physiological function due to the gradual alteration of molecules, cells and tissues. Reactive oxygen species (ROS) are the by-product of aerobic metabolism, and their increase is physiologically counteracted by the activation of the antioxidant machinery. A typical hallmark of aging is the imbalance of such equilibrium, due to either an increase of the amount of radicals or a failure of the antioxidant system. Literature reports that physical exercise is able to restore and maintain the homeostasis of oxidants and antioxidants during aging. Recently, growing interest has been turned to functional fitness, a special physical activity aimed to enhance the ability to perform everyday tasks, such as dressing, climbing stairs and preparing meals. The aim of this work was to assess whether a 24 weeks-functional fitness program carried out on 28 elderly participants (57-86 years old) could be able to improve their oxidative status. For this purpose, dROMs (diacron Reactive Oxygen Metabolites) and BAP (Biological Antioxidant Potential) were analysed at the beginning and at the end of the study. Furthermore, both plasma and saliva protein carbonylation levels were explored through proteomics analysis.
Pietro Amedeo Modesti,
Effect of Functional Fitness on Plasma Oxidation Level in Elders: Reduction of the Plasma Oxidants and Improvement of the Antioxidant Barrier, American Journal of Sports Science.
Vol. 6, No. 2,
2018, pp. 55-64.
da Cruz AC, Petronilho F, Heluany CC, Vuolo F, Miguel SP, Quevedo J, Romano-Silva MA, Dal-Pizzol F., ‘Oxidative stress and aging: correlation with clinical parameters’, Aging Clin. Exp. Res., vol. 26, no. 1, pp. 7–12, Feb. 2014.
D. Harman, ‘Aging: a theory based on free radical and radiation chemistry’, J. Gerontol., vol. 11, no. 3, pp. 298–300, Jul. 1956.
K. B. Pandey, M. M. Mehdi, P. K. Maurya, and S. I. Rizvi, ‘Plasma protein oxidation and its correlation with antioxidant potential during human aging’, Dis. Markers, vol. 29, no. 1, pp. 31–36, 2010.
D. Harman, ‘The free radical theory of aging’, Antioxid. Redox Signal., vol. 5, no. 5, pp. 557–561, Oct. 2003.
Guidi F, Magherini F, Gamberi T, Bini L, Puglia M, Marzocchini R, Ranaldi F, Modesti PA, Gulisano M, Modesti A., ‘Plasma protein carbonylation and physical exercise’, Mol. Biosyst., vol. 7, no. 3, pp. 640–650, Mar. 2011.
S. I. Rizvi, R. Jha, and P. K. Maurya, ‘Erythrocyte plasma membrane redox system in human aging’, Rejuvenation Res., vol. 9, no. 4, pp. 470–474, 2006.
A. M. Jacomini, D. D. Dias, J. O. Brito, R. F. da Silva, H. L. Monteiro, S. Llesuy, K. De Angelis, S. L. Amaral, A. S. Zago, ‘Influence of Estimated Training Status on Anti and Pro-Oxidant Activity, Nitrite Concentration, and Blood Pressure in Middle-Aged and Older Women’, Front. Physiol., vol. 8, Mar. 2017.
M. Berchicci, G. Lucci, and F. Di Russo, ‘Benefits of Physical Exercise on the Aging Brain: The Role of the Prefrontal Cortex’, J. Gerontol. A. Biol. Sci. Med. Sci., vol. 68, no. 11, pp. 1337–1341, Nov. 2013.
Cebula A, Tyka AK, Pilch W, Szyguła Z, Pałka T, Sztafa-Cabała K, Frączek B, Tyka A, ‘Effects of 6-week Nordic walking training on body composition and antioxidant status for women > 55 years of age’, Int. J. Occup. Med. Environ. Health, vol. 30, no. 3, pp. 445–454, May 2017.
E. E. Hill, E. Zack, C. Battaglini, M. Viru, A. Viru, and A. C. Hackney, ‘Exercise and circulating cortisol levels: the intensity threshold effect’, J. Endocrinol. Invest., vol. 31, no. 7, pp. 587–591, Jul. 2008.
D I Corazza, E Sebastião, R Valle Pedroso, C A Almeida Andreatto, F Gomes de Melo Coelho, S Gobbi, E Teodorov, R Ferreira Santos-Galduróz, ‘Influence of chronic exercise on serum cortisol levels in older adults’, Eur. Rev. Aging Phys. Act., vol. 11, no. 1, pp. 25–34, Apr. 2014.
L. L. de Melo, V. H. Menec, and A. E. Ready, ‘Relationship of functional fitness with daily steps in community-dwelling older adults’, J. Geriatr. Phys. Ther. 2001, vol. 37, no. 3, pp. 116–120, Sep. 2014.
Yang HJ1,, Chen KM, Chen MD, Wu HC, Chang WJ, Wang YC, Huang HT, ‘Applying the transtheoretical model to promote functional fitness of community older adults participating in elastic band exercises’, J. Adv. Nurs., vol. 71, no. 10, pp. 2338–2349, Oct. 2015.
U. Cornelli, R. Terranova, S. Luca, M. Cornelli, and A. Alberti, ‘Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress’, J. Nutr., vol. 131, no. 12, pp. 3208–3211, Dec. 2001.
R. Trotti, M. Carratelli, and M. Barbieri, ‘Performance and clinical application of a new, fast method for the detection of hydroperoxides in serum’, Panminerva Med., vol. 44, no. 1, pp. 37–40, Mar. 2002.
Martinovic J, Dopsaj V, Dopsaj MJ, Kotur-Stevuljevic J, Vujovic A, Stefanovic A, Nesic G., ‘Long-term effects of oxidative stress in volleyball players’, Int. J. Sports Med., vol. 30, no. 12, pp. 851–856, Dec. 2009.
Pacini S., Branca J. J., Gulisano M., Levi Micheli M., Ceroti M., Ruggiero M., Morucci G., ‘Salivary testosterone and cortisol levels to assess conditioning training program in rugby union players’, Med. Sport (Roma), vol. 67, pp. 449–463, Sep. 2014.
Carpentieri A, Gamberi T, Modesti A, Amoresano A, Colombini B, Nocella M, Bagni MA, Fiaschi T, Barolo L, Gulisano M, Magherini F, ‘Profiling Carbonylated Proteins in Heart and Skeletal Muscle Mitochondria from Trained and Untrained Mice’, J. Proteome Res., vol. 15, no. 10, pp. 3666–3678, Oct. 2016.
‘WHO | Obesity: preventing and managing the global epidemic’, WHO. [Online]. Available: http://www.who.int/entity/nutrition/publications/obesity/WHO_TRS_894/en/index.html. [Accessed: 26-Sep-2017].
‘Body mass index: MedlinePlus Medical Encyclopedia’. [Online]. Available: https://medlineplus.gov/ency/article/007196.htm. [Accessed: 25-Sep-2017].
G. H. Ice, A. Katz-Stein, J. Himes, and R. L. Kane, ‘Diurnal cycles of salivary cortisol in older adults’, Psychoneuroendocrinology, vol. 29, no. 3, pp. 355–370, Apr. 2004.
Martarelli D, Verdenelli MC, Scuri S, Cocchioni M, Silvi S, Cecchini C, Pompei P ‘Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training’, Curr. Microbiol., vol. 62, no. 6, pp. 1689–1696, Jun. 2011.
R. Rowiński, M. Kozakiewicz, K. Kędziora-Kornatowska, E. Hübner-Woźniak, and J. Kędziora, ‘Markers of oxidative stress and erythrocyte antioxidant enzyme activity in older men and women with differing physical activity’, Exp. Gerontol., vol. 48, no. 11, pp. 1141–1146, Nov. 2013.
Fraile-Bermúdez AB, Kortajarena M, Zarrazquin I, Maquibar A, Yanguas JJ, Sánchez-Fernández CE, Gil J, Irazusta A, Ruiz-Litago F, ‘Relationship between physical activity and markers of oxidative stress in independent community-living elderly individuals’, Exp. Gerontol., vol. 70, pp. 26–31, Oct. 2015.
C. M. Wong, L. Marcocci, L. Liu, and Y. J. Suzuki, ‘Cell signaling by protein carbonylation and decarbonylation’, Antioxid. Redox Signal., vol. 12, no. 3, pp. 393–404, Mar. 2010.
B. Can. O. Kara, M. C. Kizilarslanoglu, G. Arik, G. S. Aycicek, F. Sumer, R. Civelek, C. Demirtas, Z. Ulger, ‘Serum markers of inflammation and oxidative stress in sarcopenia’, Aging Clin. Exp. Res., vol. 29, no. 4, pp. 745–752, Aug. 2017.