Systemic Responses of Inflammation-Related Factors Following Eccentric Exercise in Humans
American Journal of Sports Science
Volume 6, Issue 2, June 2018, Pages: 32-37
Received: Oct. 11, 2017; Accepted: Oct. 26, 2017; Published: Mar. 16, 2018
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Anastassios Philippou, Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Maria Maridaki, Department of Sports Medicine & Biology of Physical Activity, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece
Constantinos Psarros, Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Michael Koutsilieris, Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Background: Exercise-induced muscle damage is followed by muscle adaptation which has been associated with an inflammatory response and is influenced by a crucial balance between pro- and anti-inflammatory cytokines. This study investigated the pattern of systemic cytokine responses for several hours after muscle-damaging exercise. Methods: Nine healthy, young men volunteers performed 50 maximal eccentric muscle actions with each leg using the knee extensors. Serum levels of interleukin (IL)-1α, IL-2, IL-6 and IL-10, transforming growth factor (TGF)-β1 and tumor necrosis factor (TNF)-α were measured by ELISA before and at 6, 48 and 120 hours post-exercise. Results: Volunteers reported significant muscle soreness and their serum creatine kinase (CK) activity increased gradually up to 120 hrs post-exercise (p<0.05). Circulating levels of IL-1a remained unaltered and TGF-β1 increased slightly over time, while IL-2 showed a moderate increase 48 hrs following eccentric exercise (p>0.05). Levels of TNF-α and IL-10 exhibited a similar pattern of response over time, showing a nearly 50% and 100% increase, respectively, 6 hrs post-exercise, while IL-6 increase significantly 6 and 48 hrs post-exercise (p<0.05). Conclusion: These findings suggest that eccentric exercise might trigger a systemic, predominantly anti-inflammatory, acute cytokine response as part of the adaptation process to muscle damage, where IL-6 may be especially involved.
Cytokines, IL-6, IL-10, Muscle Damage, TGF-β1, TNF-α
To cite this article
Anastassios Philippou, Maria Maridaki, Constantinos Psarros, Michael Koutsilieris, Systemic Responses of Inflammation-Related Factors Following Eccentric Exercise in Humans, American Journal of Sports Science. Vol. 6, No. 2, 2018, pp. 32-37. doi: 10.11648/j.ajss.20180602.11
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