Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls

Hong Wang; Bruce Paul Daggy; Jamie Francine McManus; Les G Wong

doi:doi:10.11648/j.jfns.20180605.13

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Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls

Hong Wang, Bruce Paul Daggy, Jamie Francine McManus, Les G Wong

Received: 10 October 2018 Accepted: 2 November 2018 Published: 26 November 2018

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Abstract

Telomeres are DNA-protein complexes that cap chromosomal ends to promote chromosomal stability. Telomere length has been associated with diet and nutrition and inversely associated with mortality, life stress, and diseases. The objective of the current study was to explore the effect of long-term intake of multiple dietary supplements on telomere length in adults compared with age-matched controls. Salivary telomere lengths were determined from a group of heavy supplement users (HSU group; n=81; 20 males and 61 females age 30-79), the majority of whom took > 12 different supplements daily at least 4 days per week for at least 5 years, compared to a population of relatively healthy, non-smoking, age-matched subjects in the San Francisco Bay Area (control group; n=323; 146 males and 177 females) who took ≤ 3 different supplements daily. Telomere lengths were measured by quantitative PCR to determine the telomere-to-single copy gene (T/S) ratio and were compared between groups that were age-matched by decade from 30 to 79. There was an age effect (p≤0.05) and a significant difference between groups (p≤0.001). The HSU group had significantly longer telomere length in the 50s, 60s, and 70s age groups (p ≤0.01, 0.001, 0.01 respectively). Routine clinical blood chemistry biomarkers (glucose, lipid profiles, liver enzymes, renal function and CRP) in both groups were all within the normal ranges. The results of this cross-sectional study suggest that heavy dietary supplementation may attenuate telomere shortening compared to an age-matched control group. Longitudinal studies are needed to further explore the potential association between nutritional supplementation, healthy aging and the reduced rate of telomere shortening.

DOI	10.11648/j.jfns.20180605.13
Published in	Journal of Food and Nutrition Sciences (Volume 6, Issue 5, September 2018)
Page(s)	129-134
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Telomere Length, Telomere Shortening, Dietary Supplements, Nutrients, Diets, Oxidative Stress, Inflammation

References

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APA Style

Hong Wang, Bruce Paul Daggy, Jamie Francine McManus, Les G Wong. (2018). Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls. Journal of Food and Nutrition Sciences, 6(5), 129-134. https://doi.org/10.11648/j.jfns.20180605.13

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ACS Style

Hong Wang; Bruce Paul Daggy; Jamie Francine McManus; Les G Wong. Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls. J. Food Nutr. Sci. 2018, 6(5), 129-134. doi: 10.11648/j.jfns.20180605.13

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AMA Style

Hong Wang, Bruce Paul Daggy, Jamie Francine McManus, Les G Wong. Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls. J Food Nutr Sci. 2018;6(5):129-134. doi: 10.11648/j.jfns.20180605.13

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@article{10.11648/j.jfns.20180605.13,
  author = {Hong Wang and Bruce Paul Daggy and Jamie Francine McManus and Les G Wong},
  title = {Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {6},
  number = {5},
  pages = {129-134},
  doi = {10.11648/j.jfns.20180605.13},
  url = {https://doi.org/10.11648/j.jfns.20180605.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20180605.13},
  abstract = {Telomeres are DNA-protein complexes that cap chromosomal ends to promote chromosomal stability. Telomere length has been associated with diet and nutrition and inversely associated with mortality, life stress, and diseases. The objective of the current study was to explore the effect of long-term intake of multiple dietary supplements on telomere length in adults compared with age-matched controls. Salivary telomere lengths were determined from a group of heavy supplement users (HSU group; n=81; 20 males and 61 females age 30-79), the majority of whom took > 12 different supplements daily at least 4 days per week for at least 5 years, compared to a population of relatively healthy, non-smoking, age-matched subjects in the San Francisco Bay Area (control group; n=323; 146 males and 177 females) who took ≤ 3 different supplements daily. Telomere lengths were measured by quantitative PCR to determine the telomere-to-single copy gene (T/S) ratio and were compared between groups that were age-matched by decade from 30 to 79. There was an age effect (p≤0.05) and a significant difference between groups (p≤0.001). The HSU group had significantly longer telomere length in the 50s, 60s, and 70s age groups (p ≤0.01, 0.001, 0.01 respectively). Routine clinical blood chemistry biomarkers (glucose, lipid profiles, liver enzymes, renal function and CRP) in both groups were all within the normal ranges. The results of this cross-sectional study suggest that heavy dietary supplementation may attenuate telomere shortening compared to an age-matched control group. Longitudinal studies are needed to further explore the potential association between nutritional supplementation, healthy aging and the reduced rate of telomere shortening.},
 year = {2018}
}

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TY  - JOUR
T1  - Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls
AU  - Hong Wang
AU  - Bruce Paul Daggy
AU  - Jamie Francine McManus
AU  - Les G Wong
Y1  - 2018/11/26
PY  - 2018
N1  - https://doi.org/10.11648/j.jfns.20180605.13
DO  - 10.11648/j.jfns.20180605.13
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 129
EP  - 134
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20180605.13
AB  - Telomeres are DNA-protein complexes that cap chromosomal ends to promote chromosomal stability. Telomere length has been associated with diet and nutrition and inversely associated with mortality, life stress, and diseases. The objective of the current study was to explore the effect of long-term intake of multiple dietary supplements on telomere length in adults compared with age-matched controls. Salivary telomere lengths were determined from a group of heavy supplement users (HSU group; n=81; 20 males and 61 females age 30-79), the majority of whom took > 12 different supplements daily at least 4 days per week for at least 5 years, compared to a population of relatively healthy, non-smoking, age-matched subjects in the San Francisco Bay Area (control group; n=323; 146 males and 177 females) who took ≤ 3 different supplements daily. Telomere lengths were measured by quantitative PCR to determine the telomere-to-single copy gene (T/S) ratio and were compared between groups that were age-matched by decade from 30 to 79. There was an age effect (p≤0.05) and a significant difference between groups (p≤0.001). The HSU group had significantly longer telomere length in the 50s, 60s, and 70s age groups (p ≤0.01, 0.001, 0.01 respectively). Routine clinical blood chemistry biomarkers (glucose, lipid profiles, liver enzymes, renal function and CRP) in both groups were all within the normal ranges. The results of this cross-sectional study suggest that heavy dietary supplementation may attenuate telomere shortening compared to an age-matched control group. Longitudinal studies are needed to further explore the potential association between nutritional supplementation, healthy aging and the reduced rate of telomere shortening.
VL  - 6
IS  - 5
ER  -

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Author Information

Hong Wang

Research & Development, Shaklee Corporation, Pleasanton, USA
Bruce Paul Daggy

Research & Development, Shaklee Corporation, Pleasanton, USA
Jamie Francine McManus

Research & Development, Shaklee Corporation, Pleasanton, USA
Les G Wong

Research & Development, Shaklee Corporation, Pleasanton, USA

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APA Style

Hong Wang, Bruce Paul Daggy, Jamie Francine McManus, Les G Wong. (2018). Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls. Journal of Food and Nutrition Sciences, 6(5), 129-134. https://doi.org/10.11648/j.jfns.20180605.13

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ACS Style

Hong Wang; Bruce Paul Daggy; Jamie Francine McManus; Les G Wong. Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls. J. Food Nutr. Sci. 2018, 6(5), 129-134. doi: 10.11648/j.jfns.20180605.13

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AMA Style

Hong Wang, Bruce Paul Daggy, Jamie Francine McManus, Les G Wong. Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls. J Food Nutr Sci. 2018;6(5):129-134. doi: 10.11648/j.jfns.20180605.13

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@article{10.11648/j.jfns.20180605.13,
  author = {Hong Wang and Bruce Paul Daggy and Jamie Francine McManus and Les G Wong},
  title = {Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {6},
  number = {5},
  pages = {129-134},
  doi = {10.11648/j.jfns.20180605.13},
  url = {https://doi.org/10.11648/j.jfns.20180605.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20180605.13},
  abstract = {Telomeres are DNA-protein complexes that cap chromosomal ends to promote chromosomal stability. Telomere length has been associated with diet and nutrition and inversely associated with mortality, life stress, and diseases. The objective of the current study was to explore the effect of long-term intake of multiple dietary supplements on telomere length in adults compared with age-matched controls. Salivary telomere lengths were determined from a group of heavy supplement users (HSU group; n=81; 20 males and 61 females age 30-79), the majority of whom took > 12 different supplements daily at least 4 days per week for at least 5 years, compared to a population of relatively healthy, non-smoking, age-matched subjects in the San Francisco Bay Area (control group; n=323; 146 males and 177 females) who took ≤ 3 different supplements daily. Telomere lengths were measured by quantitative PCR to determine the telomere-to-single copy gene (T/S) ratio and were compared between groups that were age-matched by decade from 30 to 79. There was an age effect (p≤0.05) and a significant difference between groups (p≤0.001). The HSU group had significantly longer telomere length in the 50s, 60s, and 70s age groups (p ≤0.01, 0.001, 0.01 respectively). Routine clinical blood chemistry biomarkers (glucose, lipid profiles, liver enzymes, renal function and CRP) in both groups were all within the normal ranges. The results of this cross-sectional study suggest that heavy dietary supplementation may attenuate telomere shortening compared to an age-matched control group. Longitudinal studies are needed to further explore the potential association between nutritional supplementation, healthy aging and the reduced rate of telomere shortening.},
 year = {2018}
}

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TY  - JOUR
T1  - Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls
AU  - Hong Wang
AU  - Bruce Paul Daggy
AU  - Jamie Francine McManus
AU  - Les G Wong
Y1  - 2018/11/26
PY  - 2018
N1  - https://doi.org/10.11648/j.jfns.20180605.13
DO  - 10.11648/j.jfns.20180605.13
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 129
EP  - 134
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20180605.13
AB  - Telomeres are DNA-protein complexes that cap chromosomal ends to promote chromosomal stability. Telomere length has been associated with diet and nutrition and inversely associated with mortality, life stress, and diseases. The objective of the current study was to explore the effect of long-term intake of multiple dietary supplements on telomere length in adults compared with age-matched controls. Salivary telomere lengths were determined from a group of heavy supplement users (HSU group; n=81; 20 males and 61 females age 30-79), the majority of whom took > 12 different supplements daily at least 4 days per week for at least 5 years, compared to a population of relatively healthy, non-smoking, age-matched subjects in the San Francisco Bay Area (control group; n=323; 146 males and 177 females) who took ≤ 3 different supplements daily. Telomere lengths were measured by quantitative PCR to determine the telomere-to-single copy gene (T/S) ratio and were compared between groups that were age-matched by decade from 30 to 79. There was an age effect (p≤0.05) and a significant difference between groups (p≤0.001). The HSU group had significantly longer telomere length in the 50s, 60s, and 70s age groups (p ≤0.01, 0.001, 0.01 respectively). Routine clinical blood chemistry biomarkers (glucose, lipid profiles, liver enzymes, renal function and CRP) in both groups were all within the normal ranges. The results of this cross-sectional study suggest that heavy dietary supplementation may attenuate telomere shortening compared to an age-matched control group. Longitudinal studies are needed to further explore the potential association between nutritional supplementation, healthy aging and the reduced rate of telomere shortening.
VL  - 6
IS  - 5
ER  -

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