International Journal of Nutrition and Food Sciences
Volume 5, Issue 3, May 2016, Pages: 175-178
Received: Mar. 27, 2016;
Accepted: Apr. 5, 2016;
Published: Apr. 26, 2016
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Sutyarso , Department of Biology, Faculty of Mathematics and Natural Sciences University of Lampung, Bandar Lampung, Indonesia
Hendri Busman, Department of Biology, Faculty of Mathematics and Natural Sciences University of Lampung, Bandar Lampung, Indonesia
Mohammad Kanedi, Department of Biology, Faculty of Mathematics and Natural Sciences University of Lampung, Bandar Lampung, Indonesia
Muhartono , Department of Anatomical Pathology, Faculty of Medicine, University of Lampung, Bandar Lampung, Indonesia
Ginger is recognized as antioxidants and chemoprotective. Therefore the rhizome extract of this plant could allegedly reverse aging process. The study is intended to investigate the possible effects of rhizome extract of white ginger (Zingiber officinale Roxb.) on the testicular function of aging male mice (Mus musculus Linn.). Male albino mice aged 12-14 months, grouped into three consisted of 12 mice, were given extract orally as follows: 0 mg/kg (as a control), 50mg/kg and 100 mg/kg daily for 70 days. The testicular function parameters assessed were: the number of spermatogenic cells, the number and quality of sperm. Compared to control group, male mice treated with ginger extract showed significant high quality of sperm count, viability, motility and morphology (P<0.001). Histological parameters of the testis: pre-leptotene as well as pachytene spermatocytes and spermatids cells also significantly higher in the treated group (P <0.01) than that of control. In conclusion, rhizome extract of ginger effectively maintain function of reproductive system of male mice in aging process and, thus, ginger is potentially as the fertility and anti-aging herbs.
Rhizome Extract of White Ginger (Zingiber officinale Roxb) Maintains Testicular Function of Aging Mice, International Journal of Nutrition and Food Sciences.
Vol. 5, No. 3,
2016, pp. 175-178.
Wang C., Hikim A. P. S., Lue y., Leung A., Baravarian S. and Swerdloff R. S. (1999). Reproductive Aging in the Brown Norway Rat Is Characterized by Accelerated Germ Cell Apoptosis and Is Not Altered by Luteinizing Hormone Replacement. J Androl 20: 509-18.
Zahidov S. T., Hohlov A. N., Malolina E. A., Yu-Kulibin A. and Marshak T. L. (2010). Ageing of the Spermatogenesis System. Biol. Bull. 37: 10–17.
Sinha H. A. P., Rajavashisth T. B., Sinha H. I., Lue Y., Bonavera J., Leung A., Wang C., Swerdloff R. S. (1997). Significance of apoptosis in the temporal and stage-specific loss of germ cells in the adult rat after gonadotropin deprivation. Biol. Reprod57: 1193-201.
Meistrich M. L. (1993). Effects of chemotherapy and radiotherapy on spermatogenesis. Eur Urol23: 136-41
Ames B. N., Shigenaga M. K., and Hagen T. M. (1993). Oxidants, antioxidants, and the degenerative diseases of aging: Review. Proc. Natl. Acad. Sci. USA. Vol. 90, pp. 7915-7922.
Sies H. (1997). Oxidative stress: Oxidants and antioxidants. Experimental physiology 82 (2): 291–5.
Hansakul P. (2010). Celullar Aging. Thammasat Medical Journal, Vol. 10 No. 3: 311-319.
Mascolo N., Jain R., Tain S., and Capasso F. (1989). Ethnopharmacologic investigation of ginger (Zingiber officinale). J Ethno Pharmacol 27: 129–40.
Kamtchouing P., Mbongue-Fandio G. Y., Dimo T. and Jatsa H. B. (2002). Evaluation of androgenic activity of Zingiber officinale extracts in male rats. Asian J Androl 4: 299-301.
Bhandari U., Kanojia R. And Pillai K. K. (2005). Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharm 97: 227-30.
Sakr SA. Badawy GM. (2011). Effect of ginger (Zingiber officinale R.) on metiram-inhibited spermatogenesis and induced apoptosis in albino mice. J App Pharm Sci 2011; 1: 131-36.
Morakinyo A. O., Adeniyi O. S. and Arikawe A. P. (2008). Effects of Zingiber officinale on reproductive functions in the male rat. African J Biomed Res 11: 329-34.
Khaki A., Khaki A. A., Hajhosseini L., Golzar F. S. and Ainehchi N. (2014). The anti-oxidant effects of ginger and cinnamon on spermatogenesis dys-function of diabetes rats. African Tradit Comp Altern Med 11: 1-8.
Takanao H. and Abe K. (1987). Age-Related Histologic Changes in the Adult Mouse Testis. Arch. Histol. Jap., Vol. 50, No. 5 (1987) p. 533-544.
Hwang S. Y., Sohn S. H., Wee J. J., Yang J. B., Kyung J. S., Kwak Y. S., Kim S. W. and Kim S. K. (2010). Panax ginseng Improves Senile Testicular Function in Rats. J. Ginseng Res. Vol. 34, No. 4, 327-335.
Chandrashekar V., Dawson C. R., Martin E. R., Rocha J. S., Bartke A. and Kopchick J. J. (2007). Age-Related Alterations in Pituitary and Testicular Functions in Long-Lived Growth Hormone Receptor Gene-Disrupted Mice. Endocrinology, 148(12): 6019–6025.
Aleissa M. S. (2014). Effect of ginger supplements on some reproductive parameters and spermatogenesis of mice. Indian J Fund Appl Life Sci 4: 271-77.
Hozayen W. G., Soliman H. A. and Abou-Seif H. S. (2014). Study of the chemopreventive effects of Zingiber officinale roots against aspartame induced testicular toxicity in rat model. J Phys Pharm Adv 4: 360-67.
Zahedi A. And Khaki A. (2014). Recovery effect of Zingiber officinale on testis tissue after treatment with gentamicin in rats. J Med Plant Res 8: 288-91.
Rasyidah T. I., Suhana S., Nur H. A., Kaswandi M. A. and Noah R. M. (2014). Evaluation of antioxidant activity of Zingiber officinale (ginger) on formalin-induced testicular toxicity in rats. J Med Bioeng 3: 149-53.
Maheshwari A., Misro M. M., Aggarwal A., Sharma R. K. and Nadan D. (2011). N-Acetyl-L-cysteine counteracts oxidative stress and prevents H2O2 induced germ cell apoptosis through down-regulation of caspase-9 and JNK/c-jun. Moll Reprod Dev78: 69-79.
Khaki A., Fathiazad F., Nouri M., Khaki A. And Chelar C. O., Marefat N. And Hamadeh M. (2009). The Effects of Ginger on Spermatogenesis and Sperm parameters of Rat. Iranian J Reprod Med 7: 7-12.
Hafez D. A. (2010). Effect of extracts of ginger goots and cinnamon bark on fertility of male diabetic rats. J Am Sci 6: 940-47.
Sekiwa Y., Kubota K. and Kobayashi A. (2008). Isolation of novel glycosides from ginger and their atioxidative activity. J Agri Food Chem 8: 373-79.
Khaki A., Khaki A. A., Hajhosseini L., Golzar F. S. and Ainehchi N. (2014). The anti-oxidant effects of ginger and cinnamon on spermatogenesis dysfunction of diabetes rats. AfricanTradit Comp Altern Med 11: 1-8.
Mares W. A. A. K. and Najam W. S. (2012). The effect of ginger on semen parameters and serum FSH. LH & testosterone of infertile men. Tikrit Medical J 18: 322-29.
Morakinyo A. O., Achema P. U. and Adegoke O. A. (2010). Effect of Zingiber officinale (Ginger) on sodium arsenit-induced reproductive toxicity in male rats. African J Biomed Res 13: 39-45.
Morakinyo A. O., Oludare G. O., Aderinto O. T. and Tasdup A. (2011). Antioxidant and free radical scavenging activities of aqueous and ethanol extracts of Zingiber officinale. Biol Med 3: 25-30.
Mahmoud R. H. and Elnour W. A. (2013). Comparative evaluation of the efficacy of ginger and orlistat on obesity management, pancreatic lipase and liver peroxisomal catalase enzyme in male albino rats. Eur Rev Med Pharmacol Sci 17 (1): 75-83.
Ghorbani R., Mokhtari T., Khazaei M., Salahshoor M. R., Jalili C. and Bakhtiari M. (2014). The effect of walnut on the weight, blood glucose and sex hormones of diabetic male rats. Int. J. Morphol. 32(3): 833-838.