International Journal of Nutrition and Food Sciences

| Peer-Reviewed |

Antimicrobial Peptides Past, Present and Future

Received: 5 January 2016    Accepted: 6 January 2016    Published: 18 October 2016
Views:       Downloads:

Share This Article

Abstract

Uncontrolled antibiotic use lead to increasing the level of resistant bacterial species. Antimicrobial peptides (AMPs) are one of the few alternatives in the fight with everyday growing bacterial resistance to commonly used antibiotics. AMPs general application could be also as endotoxin neutralizing agents or as an adjuvants to regular antimicrobial therapy. In this review we were focused on the most recent data that concern the diverse use of AMPs, their activities and modes of actions.

DOI 10.11648/j.ijnfs.s.2016050601.11
Published in International Journal of Nutrition and Food Sciences (Volume 5, Issue 6-1, December 2016)

This article belongs to the Special Issue Analytical and Microbiological Characterization of Antimicrobial Peptides

Page(s) 1-4
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antimicrobial Peptides, Bacterial Resistance, Antibiotics

References
[1] European Centre for Disease Prevention and Control Antimicrobial Resistance Interactive Database (EARS-NET) data for 2013.
[2] G. Y. Jerold, E. G. Romanowski and A. M. McDermott. “A Review of Antimicrobial Peptides and Their Therapeutic Potential as Anti-Infective Drugs.” Current eye research, vol.30, pp. 505–515, 2005. PMC. Web. 11 Dec. 2015.
[3] N. Y. Yount and M. R. Yeaman. “Multidimensional signatures in antimicrobial peptides.” Proc Natl Acad Sci USA. Vol. 101, pp. 7363–7368, 2004.
[4] M. Zasloff. “Antimicrobial peptides of multicellular organisms.” Nature. Vol. 415, pp. 389–395, 2002.
[5] H. M. Lamb, and L. R. Wiseman. Pexiganan acetate. Drugs. Vol. 56, pp. 1047–1052. discussion 1053–1044, 1998.
[6] http://www.dipexiumpharmaceuticals.com/locilex/clinical-trials.
[7] Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer. https://clinicaltrials.gov/ ct2/show/NCT00022373.
[8] H. Choi and D. G. Lee. “Synergistic effect of antimicrobial peptide arenicin-1 in combination with antibiotics against pathogenic bacteria.” Res Microbiol. Vol. 163(6-7), pp. 479-86, July 2012. doi: 10.1016/j.resmic.2012.06.001. Epub 2012 Jun 15.
[9] J. M. Kahlenberg and M. J. Kaplan, “Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease.” J. immunol. Vol. 191, pp. 4895-4901, November 2013; doi: 10.4049/jimmunol.1302005.
[10] W. A. Lynn, “Anti-endotoxin therapeutic options for the treatment of sepsis.” J. Antimicrob. Chemother. Vol. 41, pp. 71-80, 1998; doi: 10.1093/jac/41.suppl_1.71.
[11] J. C. Hurley. “Towards Clinical Applications of Anti-endotoxin Antibodies; A Re-appraisal of the Disconnect.” Toxins. vol. 5(12), pp. 2589–2620, 2013 http://doi.org/10.3390/toxins5122589.
[12] L. Xu, S. Chou, J. Wang, C. Shao, W. Li, X. Zhu and A. Shan, “Antimicrobial activity and membrane-active mechanism of tryptophan zipper-like β-hairpin antimicrobial peptides.” Amino Acids. Vol. 47, pp. 2385-2397, November 2015. DOI: 10.1007/s00726-015-2029-7.
[13] B. J. Dong, Z. G. Zhan, R. Q. Zheng, W. Chen and J. J. Min, “CDNA cloning and functional characterisation of four antimicrobial peptides from Paa spinosa.” Z Naturforsch C. Vol. 70(9), pp. 251-256, September 2015; DOI: 10.1515/znc-2015-4220.
[14] Y. Liu, J. Eichler and M. Pischetsrieder, “Virtual screening of a milk peptide database for the identification of food-derived antimicrobial peptides” Mol Nutr Food Res, vol. 59, pp. 2243-2254, July 2015; DOI: 10.1002/mnfr.201500182.
[15] C. Cézard, V. Silva-Pires, C. Mullié and P. Sonnet, Antibacterial Peptides: A Review in Science against microbial pathogens: communicating current research and technological advances, A. Méndez-Vilas (Ed.), pp. 926–937, ©FORMATEX 2011.
[16] A. P. Gomes, J. F. Mano, J. A. Queiroz and I. C. Gouveia. “Incorporation of antimicrobial peptides on functionalized cotton gauzes for medical applications.” Carbohydr Polym, vol.127, pp. 451-461, August 2015. DOI: 10.1016/j.carbpol.2015.03.089.
[17] R. J. Blower, S. M. Barksdale and M. L. van Hoek. “Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective against Burkholderia thailandensis.” PLoS Negl Trop Dis, Vol. 9, pp. e0003862, July 2015.
[18] G. Rajasekaran, R. Kamalakannan and S. Y. Shin. “Enhancement of the anti-inflammatory activity of temporin-1Tl-derived antimicrobial peptides by tryptophan, arginine and lysine substitutions.” J. Pept. Sci., Vol. 21, pp. 779-785, August 2015; DOI: 10.1002/psc.2807.
[19] C. F. Le, M. Y. Yusof, H. Hassan and S. D. Sekaran. “In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin.” Sci. Rep., Vol. 5, pp. 9761. May 2015; DOI: 10.1038/srep09761.
Cite This Article
  • APA Style

    Yotova Maya, Kaloyanov Kaloyan, Petar Donchev, Zdraveva Petranka, Pencheva Ivanka. (2016). Antimicrobial Peptides Past, Present and Future. International Journal of Nutrition and Food Sciences, 5(6-1), 1-4. https://doi.org/10.11648/j.ijnfs.s.2016050601.11

    Copy | Download

    ACS Style

    Yotova Maya; Kaloyanov Kaloyan; Petar Donchev; Zdraveva Petranka; Pencheva Ivanka. Antimicrobial Peptides Past, Present and Future. Int. J. Nutr. Food Sci. 2016, 5(6-1), 1-4. doi: 10.11648/j.ijnfs.s.2016050601.11

    Copy | Download

    AMA Style

    Yotova Maya, Kaloyanov Kaloyan, Petar Donchev, Zdraveva Petranka, Pencheva Ivanka. Antimicrobial Peptides Past, Present and Future. Int J Nutr Food Sci. 2016;5(6-1):1-4. doi: 10.11648/j.ijnfs.s.2016050601.11

    Copy | Download

  • @article{10.11648/j.ijnfs.s.2016050601.11,
      author = {Yotova Maya and Kaloyanov Kaloyan and Petar Donchev and Zdraveva Petranka and Pencheva Ivanka},
      title = {Antimicrobial Peptides Past, Present and Future},
      journal = {International Journal of Nutrition and Food Sciences},
      volume = {5},
      number = {6-1},
      pages = {1-4},
      doi = {10.11648/j.ijnfs.s.2016050601.11},
      url = {https://doi.org/10.11648/j.ijnfs.s.2016050601.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.s.2016050601.11},
      abstract = {Uncontrolled antibiotic use lead to increasing the level of resistant bacterial species. Antimicrobial peptides (AMPs) are one of the few alternatives in the fight with everyday growing bacterial resistance to commonly used antibiotics. AMPs general application could be also as endotoxin neutralizing agents or as an adjuvants to regular antimicrobial therapy. In this review we were focused on the most recent data that concern the diverse use of AMPs, their activities and modes of actions.},
     year = {2016}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Antimicrobial Peptides Past, Present and Future
    AU  - Yotova Maya
    AU  - Kaloyanov Kaloyan
    AU  - Petar Donchev
    AU  - Zdraveva Petranka
    AU  - Pencheva Ivanka
    Y1  - 2016/10/18
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ijnfs.s.2016050601.11
    DO  - 10.11648/j.ijnfs.s.2016050601.11
    T2  - International Journal of Nutrition and Food Sciences
    JF  - International Journal of Nutrition and Food Sciences
    JO  - International Journal of Nutrition and Food Sciences
    SP  - 1
    EP  - 4
    PB  - Science Publishing Group
    SN  - 2327-2716
    UR  - https://doi.org/10.11648/j.ijnfs.s.2016050601.11
    AB  - Uncontrolled antibiotic use lead to increasing the level of resistant bacterial species. Antimicrobial peptides (AMPs) are one of the few alternatives in the fight with everyday growing bacterial resistance to commonly used antibiotics. AMPs general application could be also as endotoxin neutralizing agents or as an adjuvants to regular antimicrobial therapy. In this review we were focused on the most recent data that concern the diverse use of AMPs, their activities and modes of actions.
    VL  - 5
    IS  - 6-1
    ER  - 

    Copy | Download

Author Information
  • Medical Colledge, Medical University- Pleven, Pleven, Bulgaria

  • Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria

  • Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria

  • Department of Pharmacognosy, Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria

  • Department of Pharmaceutical chemistry, Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria

  • Sections